Myocardial Imaging with<sup>123</sup>l-Hexadecenoic Acid

Poe, Norman D.; Robinson, G. D.; Zielinski, Florian W.; Cabeen, W R; Smith, James W.; Gomes, Antoinette S.

doi:10.1148/124.2.419

Cited by 58 publications

(33 citation statements)

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“…In mid 1970's, several iodinated long chain fatty acids were developed by introducing radioiodine to the terminal position of fatty acids without altering extraction efficiency compared with the natural compound [19][20][21]. These straight chain fatty acids, 123 Ihexadecanoic acid (IHXA) and 123 I -heptadecanoic acid (IHDA) were proved to be an indicator of myocardial perfusion in canine model and human [20,21]. After rapid initial myocardial extraction these traces showed biexponential clearance similar to that of 11 Cpalmitate with rapid and slow components, those were thought to represent β-oxidation of fatty acids and fatty acids storage in lipid pool, respectively.…”

Section: Tracers For Fatty Acid Imaging For Spect (Fig 3)mentioning

confidence: 99%

“…After rapid initial myocardial extraction these traces showed biexponential clearance similar to that of 11 Cpalmitate with rapid and slow components, those were thought to represent β-oxidation of fatty acids and fatty acids storage in lipid pool, respectively. However, a canine study suggested that washout rate of radioactivity from the heart reflected the back diffusion of deiodinated free iodine not by β-oxidation [20]. A clinical study with IHDA demonstrated high image quality early after injection but it deteriorated rapidly because of rapid reduction of myocardial counts and increase in background counts by deiodinated radioiodine [23].…”

Section: Tracers For Fatty Acid Imaging For Spect (Fig 3)mentioning

confidence: 99%

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Role of Fatty Acid Imaging with 123I- β-methyl-p-123I- Iodophenyl-Pentadecanoic Acid (123I-BMIPP) in Ischemic Heart Diseases

Taki¹,

Matsunari²,

Wakabayashi³

et al. 2013

Ischemic Heart Disease

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Section: Tracers For Fatty Acid Imaging For Spect (Fig 3)mentioning

confidence: 99%

Section: Tracers For Fatty Acid Imaging For Spect (Fig 3)mentioning

confidence: 99%

Role of Fatty Acid Imaging with 123I- β-methyl-p-123I- Iodophenyl-Pentadecanoic Acid (123I-BMIPP) in Ischemic Heart Diseases

Taki¹,

Matsunari²,

Wakabayashi³

et al. 2013

Ischemic Heart Disease

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“…1) In mid 1970's, several iodinated long chain fatty acids were developed by introducing radioiodine to the terminal position of fatty acids without altering extraction efficiency compared with the natural compound [14][15][16]. These straight chain fatty acids, 123 I-hexadecanoic acid (IHXA) and 123 I -heptadecanoic acid (IHDA) were proved to be an indicator of myocardial perfusion in canine model and human [15,16]. After rapid initial myocardial extraction these traces showed biexponential clearance (rapid and slow components) similar to that of 11 C-palmitate.…”

Section: Myocardial Fatty Acid Uptake and Metabolismmentioning

confidence: 99%

Metabolic imaging using SPECT

Taki

Matsunari²

2007

Eur J Nucl Med Mol Imaging

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In normal condition, the heart obtains more than two-thirds of the energy from oxidative metabolism of the long chain fatty acids, although a wide variety of substrates such as glucose, lactate, keton bodies and aminoacids are also utilized. In ischemic myocardium, on the other hand, oxidative metabolism of free fatty acid is suppressed and anaerobic glucose metabolism play a major role for residual oxidative metabolism. Therefore, metabolic imaging can be an important technique for the assessment of various cardiac diseases and conditions. In SPECT, up to the present, several iodinated fatty acid traces have been introduced and studied. Of these, I-123 labeled 15-(p-iodophenyl)3R, S-methylpentadecanoic acid (BMIPP) has been the most commonly used tracers in clinical studies, especially in some of the European countries and Japan. In this review article the 1 characterization of the several fatty acid tracers for SPECT are described and basic and clinical utility of BMIPP are further discussed. IntroductionThe cardiac muscle metabolizes a variety of substrates by selecting appropriate ones available in the particular myocardial condition. In normal condition, fatty acids and glucose are the most preferred substrate for energy production, followed by lactate, amino acids, keton bodies. Approximately two-thirds or more of the total energy produced by myocardium is derived from fatty acid oxidation and the most of the remaining energy is covered by the glucose metabolism. Both fatty acid and glucose are catabolized to acetyl-COA through beta-oxidation and glycolysis and the metabolite is oxidized in the tricarboxylic acid (TCA) cycle. In various pathological conditions the myocardial metabolism can be changed significantly, for instance, in ischemia, oxidative metabolism of free fatty acid is decreased because ß-oxidation of fatty acid in mitochondria requires a large amount of oxygen, and glucose becomes the preferred substrate for anaerobic glycolysis that requires less oxygen consumption [1,2]. Therefore, imaging tracers that permit direct assessment of myocardial metabolism are desired to evaluate the pathophysiological changes in various heart disease. Current available tracers for metabolic imaging are several fatty acid tracers, 18 F-FDG for the evaluation of glucose metabolism, and 11 C-acetate for the

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“…With a myocardial half-life of 25 min (196), 1231-labeled hexadecenoic acid demonstrated ischemic defects in patients with coronary artery disease (196) or infarctions (197). The extraction rate of -70% was comparable to that of potassium 43 (198).…”

Section: Cold Spot Imagingmentioning

confidence: 99%