Myocardial Infarction

Becker, Diane M.; Birger, M.; Samuel, Erica A.; S, Floru

doi:10.1097/00005053-198806000-00010

Cited by 12 publications

(2 citation statements)

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“…It is possible that NMS may cause myocardial damage. 2 Specifically, NMS is often accompanied by increased CK, also known as creatine phosphokinase. CK is an enzyme expressed by various tissue and cell types, including the myocardium.…”

Section: Discussionmentioning

confidence: 99%

“…The primary symptoms of NMS are the classical tetrad of altered consciousness, hyperpyrexia, muscular rigidity, and autonomic instability. [1][2][3] In addition, patients exhibit elevated serum creatine kinase (CK) and leukocytosis, among other symptoms. 3,4 In contrast, abnormally elevated cardiac troponin I (TNI) levels are rare in this syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Neuroleptic malignant syndrome with abnormally elevated cardiac troponin I: a case report

et al. 2020

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Neuroleptic malignant syndrome (NMS) is a life-threatening neurological emergency that is primarily characterized by altered consciousness, hyperpyrexia, muscular rigidity, and autonomic instability. Here, we describe a unique case of NMS. A 54-year-old woman with major depressive disorder (MDD) was admitted to our hospital to relieve painful emotions; her laboratory tests and physical examinations were unremarkable. Her medication regime was as follows: day 1, quetiapine (200 mg), clonazepam (2 mg), and zopiclone (7.5 mg); day 2, olanzapine (5 mg) and sertraline (100 mg); day 3, olanzapine (15 mg), sertraline (100 mg), zopiclone (7.5 mg), and clonazepam (2 mg); day 4, olanzapine (15 mg) and haloperidol (5 mg); and day 5, sertraline (50 mg) and olanzapine (5 mg). The patient then developed NMS, and a series of tests showed further abnormalities. Unusually, her cardiac troponin I (TNI) was abnormally elevated as her NMS symptoms worsened, but gradually decreased after she was transferred to the cardiology department for treatment. The increased TNI was suspected to be related to the NMS. Here, we provide several potential explanations for the relationship between TNI and NMS. Based on the present case, it may be important to measure and monitor TNI concentrations in NMS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%