Myocardial infarction in qatar: The first 2515 patients

Chaikhouni, Amer; Chouhan, Lalit; Pomposiello, C.; Banna, A.; Mahrous, Farouk; Thomas, Gary W.; Al-Hassan, Noor; Khalifa, S; Jaddan, A.; Bsata, M. W.; Hajar, H.A.

doi:10.1002/clc.4960160312

Cited by 14 publications

(9 citation statements)

References 5 publications

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“…A mean ino o terval of 11.2 months has been reo o ported in children and adolescents with uncured CD before any beno o efit from RT was observed. 9 Since our patient had an initial remission and recurrence on discontinuing the drug, this suggests that the observed benefit is likely due to cabergoline. Thus cabergoline could be a useful option for inducing remission in uno o cured CD patients who have undero o gone TSS and radiotherapy.…”

Section: Remission In Cushing Dist T Ease With Cabergolinementioning

confidence: 72%

Remission in cushing disease with cabergoline

Gopal¹,

Bandgar²,

Menon³

et al. 2008

Ann Saudi Med

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Risk factors, clinical feat t tures and outcome of acute myocardial infarct t tion in Sana´a, YemenTo the Editor: According to the World Health Organization, develo o oping countries contributed to 85% of cardiovasuclar disease (CVD) deaths. 1o3 A particular cause for concern is the relatively early age of CVD deaths compared with those in developed regions. Since there are few data on the incidence and clinical course of acute myocardial infarction (AMI) in the Middle East, 4o12 we retrospectively studied the demographic and clinical charo o acteristics of patients, the prevao o lence of major risk factors and faco o tors associated with morbidity and mortality during hospitalization in the intensive care unit (ICU) of the AloThawra University Hospital in Sana' a. All patients with confirmed AMI who were admitted and treato o ed at the intensive care unit (ICU) during 36 consecutive months were enrolled in the study. The diagnosis of AMI was based on a history of typical chest pain or its equivalent, ECG changes plus an increase in peak serum creatine kinase (CK) activity from a minimum to twice the normal level. During the 3oyear study period 386 patients with AMI were admitted to the ICU. Of all patients, 348 (90.2%) were men with a mean (±SD) age 54±11 years (range, 27o82 years) and 38 (9.8%) were women with a mean age of 59±11 years (range, 38o80 years). Almost all patients (97.9%) were Yemeni. The prevalence of risk factors was as follows: khat chewing (88%), smoking (81%), total serum cholesterol (29%), diabetes mellio o tus (25%) and hypertension (18%). When classified according to site, recurrence and severity of AMI, in 57.0% there was an anterior infarco o tion, in 35.2% an inferior infarction,

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Section: Remission In Cushing Dist T Ease With Cabergolinementioning

confidence: 72%

Remission in cushing disease with cabergoline

Gopal¹,

Bandgar²,

Menon³

et al. 2008

Ann Saudi Med

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“…[5][6][7] Two striking features of the CAD epidemic among Asian Indians are a greater severity and prematurity of CAD as compared with other ethnic groups. 8 In the United Kingdom, the overall CAD mortality in Asian Indian men is 50% higher than the countrywide average, but it is 313% higher in Asian Indian men younger than 30 years of age. 6 The high rate of CAD among Asian Indians is accompanied by a paradoxically low prevalence of smoking, hypertension, and obesity.…”

mentioning

confidence: 98%

“…Asian Indian women also have a three‐ to four‐fold higher CAD mortality rate when compared to other populations 5–7 . Two striking features of the CAD epidemic among Asian Indians are a greater severity and prematurity of CAD as compared with other ethnic groups 8 . In the United Kingdom, the overall CAD mortality in Asian Indian men is 50% higher than the countrywide average, but it is 313% higher in Asian Indian men younger than 30 years of age 6 .…”

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confidence: 99%

High‐Density Lipoprotein Subclass Distribution in Individuals of Asian Indian Descent: The National Asian Indian Heart Disease Project

Superko¹,

Enas²,

Kotha³

et al. 2005

Preventive Cardiology

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Individuals of Asian Indian descent have significantly higher cardiovascular event rates as compared with other ethnic groups. The authors investigated the prevalence of metabolic disorders linked to coronary artery disease in an Asian Indian male population compared with non-Asian Indian males. Standard lipid measurements did not discriminate between groups, and the Asian Indian group exhibited less of the high coronary artery disease risk small low-density lipoprotein trait. Despite less of the small low-density lipoprotein trait in the Asian Indian group and no difference in high-density lipoprotein cholesterol, the Asian Indian group had a significantly higher prevalence (p < 0.0002) of low high-density lipoprotein 2b, implying impaired reverse cholesterol transport. This observation remained significant in the subgroup of patients with high-density lipoprotein cholesterol over 40 mg/dL, a region felt not to reflect impaired reverse cholesterol transport. Low high-density lipoprotein 2b combined with the higher lipoprotein(a) in the Asian Indian group may help explain the high prevalence of coronary artery disease in this ethnic population.

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“…The prevalence of coronary heart disease (CHD) is increasing worldwide in epidemic proportions [1][2][3], In Kuwait, CHD mortality increased about 50% over a 10-year period (1972)(1973)(1974)(1975)(1976)(1977)(1978)(1979)(1980)(1981), in contrast to a 66% decline in mortality due to infectious and parasitic dis ease over the same period [4], Current obser vations in other, recently affluent, developing countries, attribute this change in CHD mor tality in Kuwait to the changes accompanying urbanization and Westernization of the soci ety [1,5,6], It is widely recognized that hyper lipidemia [increased plasma levels of total cholesterol, low density lipoproteins (LDL) and triglycerides with reduced plasma high density lipoprotein (HDL) levels] constitutes a very important risk factor for CHD in most populations worldwide. This is likely to be the situation with Gulf Arabs (including Kuwai tis).…”

Section: Introductionmentioning

confidence: 99%

“…This is likely to be the situation with Gulf Arabs (including Kuwai tis). Recent studies among Saudi Arabian, Qatari and Bedouin Arabs indicate that hy pertension (42%), diabetes (41 %), hyperlipid emia (32%) and hyperuricemia (45%) were the most commonly seen risk factors in pa tients with CHD [5][6][7], There are no recent epidemiological stud ies on the prevalence of hyperlipidemia in Kuwait's general population, except for a few reports of patients with diabetes [8,9], In 1994, we conducted a 4-week preliminary study at the Mubarak Al-Kabeer Teaching Hospital. This study on the pattern of unse lected biochemical requests indicated that about 66% of all the biochemical test requests included requests for lipid estimation, and up to 55% of these results indicated elevated plasma lipid levels (cholesterol >6.0 mmol/1, triglycerides >2.0 mmol/1).…”

Section: Introductionmentioning

confidence: 99%

A Lipid Clinic Service in Kuwait: Preliminary Observations

Akanji¹,

Al-Suleiman²,

Tahzeeb³

et al. 1996

Med Principles Pract

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Despite a dramatic increase in the prevalence of coronary heart disease (CHD) within the Kuwaiti population, hyperlipidemia, which is an important risk factor for CHD, is inadequately characterised. Since over half of all patients seen at Kuwait’s Mubarak Teaching Hospital had elevated plasma cholesterol and/or triglyceride levels, the hospital opened a Lipid Clinic Service (LCS). The LCS provides a specialized diagnostic and therapeutic service to patients with primary hyperlipidemia. This report presents our preliminary observations on the first 150 patients seen at this clinic during the first 6 months of operation (March–September 1995). A nationality survey of the clinic attendees revealed that 46.7% were Kuwaitis, 4.0% other Gulf Arabs, 34.0% other Arabs (predominantly Egyptians) and 15.3% South Asians (predominantly Indians). Patient referrals came to the clinic from neighboring polyclinics (38.7%), hospital outpatient clinics (25.3%), clinical biochemistry laboratory (16.7%), hospital dietetic service (5.3%) as well as other sources (14.0%). Of the 117 patients with primary hyperlipidemia, 48.7% had predominant hypercholesterolemia, 23.9% were classified as mixed hyperlipidemia, and 27.4% had predominant hypertriglyceridemia. Over 75% of the men, and 22% of the women smoked regularly. About a third of the women were postmenopausal. The pattern of observations in the 28 patients with diabetes, incidentally seen in the clinic, was similar to that in the nondiabetic subjects with primary hyperlipidemia. The constellation of biochemical risk factors for CHD (higher triglyceride and uric acid and lower high density lipoprotein levels, coupled with a tendency towards central obesity and cigarette smoking) was more common in the men than in the women. This may account for a higher risk of CHD in men. Lipid and metabolic profiles did not differ between Kuwaitis and other nationals, suggesting that similar factors underlie the disorder in all patients. These features, similarly, did not differ between the pre- and postmenopausal women. This preliminary report on the first 150 patients seen in the LCS in Kuwait demonstrates a need for this type of specialized service in the country.

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Myocardial infarction in qatar: The first 2515 patients

Cited by 14 publications

References 5 publications

Remission in cushing disease with cabergoline

Remission in cushing disease with cabergoline

High‐Density Lipoprotein Subclass Distribution in Individuals of Asian Indian Descent: The National Asian Indian Heart Disease Project

A Lipid Clinic Service in Kuwait: Preliminary Observations

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