Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes

Charles, Christopher J.; ELLIOTT, John M.; NICHOLLS, M. Gary; Rademaker, Miriam T.; Richards, Mark

doi:10.1042/cs0980703

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Angioblast Systems, Inc., acquired the technology and developed the allogeneic MSC product Revascor ™ for clinical use primarily in the treatment of ischaemic cardiovascular disease. [92–95] To date, more than 20 congestive heart failure patients have received injections of Revascor ™ with no adverse events related to the cells (Dr. Silviu Itescu, Angioblast Systems, Inc., personal communication ). Angioblast has agreed to supply Revascor ™ as an ‘off-the-shelf’ product for the M. D. Anderson CB MNC/MSC co-culture expansion trial.…”

Section: J Rationale For the Use Of “Off-the-shelf” Msc For The Clinmentioning

confidence: 99%

Mesenchymal stem cells in ex vivo cord blood expansion

Robinson

Simmons

Yang

et al. 2011

Best Practice & Research Clinical Haematology

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Umbilical cord blood (CB) is becoming an important source of haematopoietic support for transplant patients lacking human leukocyte antigen matched donors. The ethnic diversity, relative ease of collection, ready availability as cryopreserved units from CB banks, reduced incidence and severity of graft versus host disease and tolerance of higher degrees of HLA disparity between donor and recipient, are positive attributes when compared to bone marrow or cytokine-mobilized peripheral blood. However, CB transplantation is associated with significantly delayed neutrophil and platelet engraftment and an elevated risk of graft failure. These hurdles are thought to be due, at least in part, to low total nucleated cell and CD34+ cell doses transplanted. Here, current strategies directed at improving TNC and CD34+ cell doses at transplant are discussed, with particular attention paid to the use of a mesenchymal stem cell (MSC)/CB mononuclear cell ex vivo co-culture expansion system.

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Section: J Rationale For the Use Of “Off-the-shelf” Msc For The Clinmentioning

confidence: 99%

Mesenchymal stem cells in ex vivo cord blood expansion

Robinson

Simmons

Yang

et al. 2011

Best Practice & Research Clinical Haematology

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“…Troponin is a globular protein complex localised on thin filaments of striated muscle and consists of three subunits; Tn-T, Tn-I and Tn-C; all three subunits are integrally involved in the contraction and relaxation of the myofibrils (Klaus 1990, Billeter and others 1994, Cardinet 1997, Reece 1997, Rice 1999, Boccara and others 2000). Troponin complex proteins have been determined in the heart muscle and blood of domestic animals (McAuliffe and Robbins 1991, O'Brien and others 1997b, 1998, Charles and others 2000, Fredericks and others 2001, Gonzales and others 2005, Gunes and others 2005, Jesty and others 2005). There is remarkable homology between the amino acid sequences of cTn in human beings and animals (O'Brien and others 1997a, 1998), but there have been few studies of its potential clinical use in veterinary medicine.…”

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confidence: 99%

Use of cardiac troponin kits for the qualitative determination of myocardial cell damage due to traumatic reticuloperitonitis in cattle

et al. 2008

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This study was designed to investigate whether kits to measure circulating cardiac troponin-I (cTn-I) and cardiac troponin-T (cTn-T) can be used to determine myocardial cell damage in cattle with traumatic reticuloperitonitis (trp). Twenty cattle with trp were compared with 10 clinically healthy cattle. cTn-I and cTn-T were determined qualitatively and cTn-I was determined quantitatively; biochemical analyses were also performed on both groups. The mean serum concentrations of total protein, globulin, glucose and calcium, and the mean activities of creatine kinase mb, aspartate aminotransferase, lactate dehydrogenase and gamma-glutamyl transferase were higher in the cattle with trp than in the control group. The cTn-I and cTn-T kits both gave positive results in three of the cattle with trp and the quantitative measurement of cTn-I was positive in 11 of the trp cases. Both tests were negative in the healthy cattle.

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“…Venous blood drawn for hormone assay was taken into chilled EDTA-coated tubes, centrifuged and the plasma stored at k80 mC before assay for plasma atrial natriuretic peptide (ANP) [9], brain natriuretic peptide (BNP) [10], N-terminal fragment of pro-BNP (NT-BNP) [11], cGMP [9], endothelin [1], aldosterone [12] and plasma renin activity (PRA) [13].…”

Section: Neurohumoral Measurementsmentioning

confidence: 99%

“…Regional wall motion (fractional shortening) was calculated in four quadrants (1)(2)(3)(4), these being posterobasal, diaphragmatic, apical anterolateral and anterobasal respectively. A 7F pigtail catheter was passed through the carotid artery sheath into the left ventricle and a 20 ml bolus of contrast medium (Omnipaque, Nycomed, Birmingham, U.K.) was injected under fluoroscopy with the image captured on video for analysis on an ANCOR workstation (Siemens, Solna, Sweden).…”

Section: Neurohumoral Measurementsmentioning

confidence: 99%

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Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep

Charles¹,

ELLIOTT²,

NICHOLLS³

et al. 2003

Clinical Science

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The impaired ability to excrete sodium is a key feature of established congestive heart failure and is also apparent in asymptomatic left ventricular (LV) impairment. However, few studies have examined responses to chronic volume loading immediately post-myocardial infarction (MI). Experimental MI was induced in six sheep by thrombogenic coil coronary artery occlusion, and resulted in significant LV dysfunction with reduced LV ejection fraction ( P =0.001) and subsequent remodelling (increased LV volumes, P =0.015). Chronic volume loading with 2, 3 and 4 litres/day intravenous saline (each for 7 days) showed no evidence of renal sodium or volume retention in sheep with experimental MI compared with six normal control sheep. Plasma levels of brain natriuretic peptide (BNP), N-terminal pro-BNP and cGMP (all P <0.05) were higher in the MI group compared with normal control sheep. There were no differences in haemodynamics, body mass or renin-aldosterone levels between groups. This study provides evidence that natriuretic peptides play a pivotal role in preserving volume/electrolyte balance in the early stages of post-MI cardiac dysfunction.

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Myocardial infarction with and without reperfusion in sheep: early cardiac and neurohumoral changes

Cited by 16 publications

References 24 publications

Mesenchymal stem cells in ex vivo cord blood expansion

Mesenchymal stem cells in ex vivo cord blood expansion

Use of cardiac troponin kits for the qualitative determination of myocardial cell damage due to traumatic reticuloperitonitis in cattle

Natriuretic peptides maintain sodium homoeostasis during chronic volume loading post-myocardial infarction in sheep

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