Myocardial Infarctions and Other Acute Coronary Syndromes in Rare Congenital Bleeding Disorders

Girolami, Antonio; Ferrari, Silvano; Sambado, Luisa; Peroni, Edoardo; Cosi, Elisabetta

doi:10.1177/1076029614548056

Cited by 6 publications

(10 citation statements)

References 29 publications

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“…Thirtyseven of those patients had a myocardial infarction (MI) or other acute coronary syndromes, five patients had an ischemic stroke, and one had a DIC considered as peripheral artery thrombosis. 2,4,5,[10][11][12][13][14][15][16][17] On the contrary, only five patients presented a venous thrombosis. 2,6,16 The A/V thrombosis ratio was 5.37 (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Discrepancies had been observed even between the hemophilias and FVII deficiency. 10 Low FXI levels seem to protect from venous thrombosis. 6 However such low levels are not protective from atherothrombosis, safe for ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent studies have shown that both arterial and venous thromboses do sometimes occur in these patients and that the event is probably not as rare as originally thought. 1,2 These observations have stimulated research in the pathogenesis of atherothrombosis and venous thrombosis. 3 Several papers have dealt with the subject and some interesting observations have become evident.…”

mentioning

confidence: 99%

“…9 Finally, it was shown that some defects seem more protective against either arterial or venous (A/V) thrombosis. 4,6,10 The purpose of the present study is to compare the occurrence of arterial and venous thromboses in congenital factor XI (FXI) or factor VII (FVII) deficiency.…”

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confidence: 99%

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Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

et al. 2016

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

et al. 2016

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“…At present, we are witnessing a revival of research into the contact phase of blood coagulation factors [1,2,3,4]. At the same time, there is a keen interest in the study of thrombotic events which occur in congenital bleeding disorders [5,6,7,8,9,10]. …”

Section: Introductionmentioning

confidence: 99%

Thrombotic Events in Asymptomatic FXII Deficiency versus Symptomatic FXI Deficiency: Surprising Observations

Girolami

Cosi²,

Sommer³

et al. 2016

Acta Haematol

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Objective: To evaluate the impact of an asymptomatic congenital clotting defect (FXII deficiency) versus that of a similar but symptomatic defect (FXI deficiency) on protection from thrombosis. Patients and Methods: All patients with FXII or FXI deficiency and thrombosis were gathered from a time-unlimited PubMed search that was carried out twice and from personal records. Combined defects were excluded. The defect had to be proven by the demonstration of a suited hereditary pattern and by a specific clotting assay. Only patients with a factor activity level of <30% of normal were selected. Results: Twenty-eight patients with an FXII deficiency presented with arterial thrombosis, mainly myocardial infarction, and 29 showed venous thrombosis; for FXI deficiency, these figures were 43 and 10, respectively. The ratio of arterial and venous thrombosis was 0.96 and 4.3, respectively, for FXII and FXI deficiency. Conclusions: Factor FXII deficiency supplies no protection from arterial or venous thrombosis. FXI deficiency shows no protection from arterial thrombosis but appears to guarantee protection from venous thrombosis. A symptomatic, namely bleeding, condition (FXI deficiency) provides protection from venous thrombosis whereas an asymptomatic one (FXII deficiency) does not.

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Association of factor V activity with risk of venous thromboembolism and atherothrombotic cardiovascular events: A retrospective population-based cohort study

Saliba

Warwar

Kotler

et al. 2018

Thrombosis Research

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Myocardial Infarctions and Other Acute Coronary Syndromes in Rare Congenital Bleeding Disorders

Abstract: The congenital hypocoagulability present in these patients was unable to allow a protection from acute coronary diseases. The significance of the findings is discussed.

Cited by 6 publications

References 29 publications

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

Congenital factor XI and factor VII deficiencies assure an apparent opposite protection against arterial or venous thrombosis: An intriguing observation

Thrombotic Events in Asymptomatic FXII Deficiency versus Symptomatic FXI Deficiency: Surprising Observations

Association of factor V activity with risk of venous thromboembolism and atherothrombotic cardiovascular events: A retrospective population-based cohort study

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