Myocardial Injuries in COVID-19: More Questions Than Answers

Bardajı́, Alfredo

doi:10.3390/jcm11154527

Cited by 1 publication

(1 citation statement)

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“…As the virus spreads, it is crucial to understand its potential acute and long-term effects on the body ( 2 ). One of the most concerning effects is its potential to damage the heart muscle, known as myocardial injury ( 3 ). Much of the information about myocardial injury and COVID-19 comes from studies conducted during the first wave of infections in the first half of 2020.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and prognostic implications of myocardial injury across different waves of COVID-19

Peiró,

Delgado-Cornejo,

Sánchez-Giménez

et al. 2024

Front. Cardiovasc. Med.

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IntroductionThe prognostic ability of myocardial injury across different waves of the COVID-19 pandemic is not well established. The purpose of this study was to evaluate the prevalence and prognostic implications of myocardial injury in the first and sixth wave of COVID-19.MethodsWe conducted a retrospective observational study that included patients admitted to the emergency department with COVID-19 with data on concentrations of cardiac troponin during the first and sixth wave. We compared the prevalence of myocardial injury and its predictive capacity for 30-day all-cause death in both waves.Results and discussionA total of 346 patients were included (1st wave 199 and 6th wave 147 patients). The prevalence of myocardial injury was 21% with non-significant differences between waves. Myocardial injury was associated, in both waves, with a higher prevalence of comorbidities and with an increased risk of 30-day all-cause death [1st wave HR: 3.73 (1.84–7.55); p < 0.001 and 6th wave HR: 3.13 (1.23–7.92); p = 0.016], with non-significant differences in predictive capacity between groups after ROC curve analysis [AUC: 1st wave 0.829 (95% CI: 0.764–0.895) and 6th wave 0.794 (95% CI: 0.711–0.876)]. As limitations, this is a retrospective study with a relatively small simple size and troponin assay was performed at the discretion of the emergency physician so selection bias could be present. In conclusion, the prevalence of myocardial injury and its prognostic capacity was similar in both waves despite vaccination programs. Myocardial injury predicts short-term mortality in all COVID-19 patients, so they should be treated intensively.

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Section: Introductionmentioning

confidence: 99%