Myocardial injury and mortality in patients with excessive oxygen administration before cardiac arrest

Abstract

In-hospital cardiac arrest (IHCA) is a prominent cause of death worldwide, and studies show documented survival rates for IHCA ranging from 0% to 42%. [1][2][3][4] The high mortality rate of patients who initially achieve return of spontaneous circulation (ROSC) after cardiac arrest (CA) can be attributed to post-cardiac arrest syndrome, which includes myocardial dysfunction, systemic ischemia/reperfusion response, anoxic cerebral injury, and persistent precipitating pathology. 5 Several modifiable factors have been investigated in the search of clinical paths to optimize treatment. The role of supplemental oxygen post-CA has gained increased attention recently. A cohort study suggested early post-resuscitation hyperoxia as an independent predictor of poor neurological function. 6 Several observational studies, including two large meta-analyzes indicate hyperoxia after

Variable oxygen administration in surgical and medical wards evaluated by 30‐day mortality—An observational study

“…These values were obtained during routine recordings of vital signs. The oxygen exposure was calculated from these specific measurements as a weighted average (of SpO2 corrected for interval between each measurement) in the first 48 hours after either ward admission for medical patients or discharge from the post‐anaesthesia care unit for surgical patients 16 . We classified oxygen exposure based on the guidelines for patients with and without COPD for SpO2 target defined by both the British Thoracic Society and the Danish Society of Respiratory Medicine 8,17 .…”