Myocardial Injury at Early Stage and Its Association With the Risk of Death in COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

Fu, Lin; Li, Xiuyong; Fei, Jun; Xiang, Ying; Xiang, Hui-Xian; Li, Meng-Die; Liu, Fangfang; Liu, Ying; Zhao, Hui; Xu, De-Xiang

doi:10.3389/fcvm.2020.590688

Cited by 15 publications

(11 citation statements)

References 25 publications

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“…Several studies conducted by our group have highlighted a series of marked changes in routine blood indices and associated instances of multiple organ injury in patients with coronavirus disease 2019 (COVID-19) [24][25][26][27], spurring the present analysis of IL-27 levels and related clinical findings in CAP patients. Overall, these analyses revealed a negative correlation between serum IL-27 and lymphocyte levels in CAP patients, whereas IL-27 concentrations were positively correlated with the counts of WBC, neutrophils and monocytes, as well as key indicators of myocardial, renal, and hepatic function.…”

Section: Discussionmentioning

confidence: 97%

Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

Xu¹,

Wang²,

Cao³

et al. 2022

Int. J. Med. Sci.

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Background:The previous studies have revealed that IL-27 was involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of IL-27 in community-acquired pneumonia (CAP) was unclear. The goal of this research was to explore the associations of serum IL-27 with the severity and prognosis among CAP patients through a prospective cohort study. Methods: The whole of 239 healthy population and 239 CAP patients were enrolled. Fasting blood samples were collected. Inflammatory cytokines were detected using enzyme linked immunosorbent assay (ELISA). Demographic characteristics and clinical information were analyzed. Results: Serum IL-27 on admission was significantly risen in CAP patients compared with control subjects. Besides, serum IL-27 was gradually increased in line with CAP severity scores. Correlative analysis suggested that serum IL-27 was associated with blood routine indices, renal function, liver function, myocardial function and inflammatory cytokines. Linear and logistic regression analyses revealed that serum IL-27 was positively correlated with CAP severity scores. Logistic regression analysis demonstrated that serum higher IL-27 on admission elevated the risks of vasoactive agent usage and longer hospital stay during hospitalization among CAP patients. Conclusions: Serum IL-27 is markedly and positively associated with the severity and poor prognosis among CAP patients, indicating that IL-27 may involve in the pathophysiological process of CAP. Serum IL-27 may be used as a biomarker for diagnosis and prognosis in CAP patients.

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Section: Discussionmentioning

confidence: 97%

Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

Xu¹,

Wang²,

Cao³

et al. 2022

Int. J. Med. Sci.

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“…A series of studies from our team found that the obvious change of blood routine indices and multiple organ injury were complicated with the disease of pneumonia [21][22][23][24]. Consequently, the associations of serum IL-27 and clinical features were analyzed among CAP patients.…”

Section: Discussionmentioning

confidence: 99%

Serum IL-27 Predicts the Severity and Prognosis in Patients With Community-acquired Pneumonia: A Prospective Cohort Study

Liu

Chen

et al. 2021

Preprint

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Background: The previous studies have revealed that IL-27 was involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of IL-27 in the community-acquired pneumonia (CAP) was unclear. The goal of this research was to explore the associations of serum IL-27 with the severity and prognosis among CAP patients through a prospective cohort study.Methods: The whole of 239 healthy population and 239 CAP patients were enrolled. Fasting blood samples were collected. Inflammatory cytokines were detected using enzyme linked immunosorbent assay (ELISA). Demographic characteristics and clinical information were analyzed. Results: Serum IL-27 was significantly risen in CAP patients compared with control subjects on admission. Besides, serum IL-27 was gradually increased in line with CAP severity scores among CAP patients. Analysis on relevance suggested that serum IL-27 was associated with blood routine indices, renal function, liver function, myocardial function and inflammatory cytokines. Linear regression and logistic regression revealed that serum IL-27 was positively correlated with CAP severity scores. Logistic regression demonstrated that serum IL-27 on admission was positively correlated with vasoactive agent usage and longer hospital stay during hospitalization among CAPO patients. Conclusions: Serum IL-27 is markedly and positively associated with the severity and poor prognosis among CAP patients, indicating that IL-27 may involve in the pathophysiological process of CAP. Serum IL-27 may be used as a diagnostic and prognostic biomarker for CAP patients.

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“…Therefore, we evaluated the association between serum S100A12 and inflammatory cytokines and found a positive correlation. Several previous studies from our team had revealed that lymphocyte reduction, liver dysfunction, renal dysfunction, and myocardial injury were observed in patients with Coronavirus disease 2019 (32)(33)(34)(35). Publishing data have revealed that Streptococcus pneumoniae or other pathogen infection rapidly initiated an inflammatory response.…”

Section: Discussionmentioning

confidence: 96%

Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study

et al. 2021

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BackgroundPrevious studies indicated the calcium-binding protein S100A12 to be involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of S100A12 has remained elusive in patients with community-acquired pneumonia (CAP). Therefore, the purpose of this prospective cohort study was to evaluate the association between serum S100A12 with severity and prognosis in CAP patients.MethodsTwo groups with either 239 CAP patients or 239 healthy controls were enrolled in our study. Fasting blood and clinical characteristics were collected. On admission, serum S100A12 was measured using enzyme-linked immunosorbent assay (ELISA).ResultsSerum S100A12 was increased in CAP patients compared to control subjects. Furthermore, serum S100A12 was elevated according to the severity of CAP. Correlative analysis suggested that the level of serum S100A12 was associated with blood routine indices, renal function markers, inflammatory cytokines and other clinical parameters among CAP patients. Additionally, linear and logistical regression analyses indicated that serum S100A12 was positively associated with CAP severity scores in CAP patients. In addition, the association of high serum S100A12 and prognosis was accessed using a follow-up research. Elevated serum S100A12 on admission increased the risk of death and hospital stay in CAP patients during hospitalization.ConclusionsElevated serum S100A12 on admission is positively associated with the severity and adverse prognosis in CAP patients, suggesting that S100A12 may involve in the pathophysiological process of CAP. The titre of serum S100A12 may be used as a biomarker for diagnosis and prognosis among CAP patients.

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Myocardial Injury at Early Stage and Its Association With the Risk of Death in COVID-19 Patients: A Hospital-Based Retrospective Cohort Study

Cited by 15 publications

References 25 publications

Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study

Serum IL-27 Predicts the Severity and Prognosis in Patients With Community-acquired Pneumonia: A Prospective Cohort Study

Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study

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