2014
DOI: 10.1155/2014/919150
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Myocardial Injury in Critically Ill Children: A Case Control Study

Abstract: Objectives. The aim of this study was to investigate the occurrence of myocardial injury in critically ill children through assessment of cardiac troponin T levels and whether levels are associated with disease severity and myocardial dysfunction measured by echocardiography. Methods. Over a 6-month period, this case control study included 50 patients admitted to Pediatric Intensive Care Unit of Zagazig University Children's Hospital. Twenty-five healthy children were included as a control group. Demographic a… Show more

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Cited by 8 publications
(8 citation statements)
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“…Many biomarkers are used in clinical practice to identify myocardial injury; cTnI and CK-MB are the most commonly used biomarkers. [11][12][13][14][15][16] However, the positive expression rate of cTnI and CK-MB is not 100%, and is 25-42% and 35-68%, respectively, 11 which is similar to the results of this study. The diagnosis of myocardial injury has certain limitations, because the expression of cTnI and CK-MB is influenced by many factors, which exist within the myocardium, CK-MB is also expressed in skeletal muscle and brain tissue, cTnI is a specific indicator of myocardial injury and an independent predictor for the severity of myocardial injury; however, sensitivity is low using the standard sensitivity assays.…”
Section: Discussionsupporting
confidence: 82%
“…Many biomarkers are used in clinical practice to identify myocardial injury; cTnI and CK-MB are the most commonly used biomarkers. [11][12][13][14][15][16] However, the positive expression rate of cTnI and CK-MB is not 100%, and is 25-42% and 35-68%, respectively, 11 which is similar to the results of this study. The diagnosis of myocardial injury has certain limitations, because the expression of cTnI and CK-MB is influenced by many factors, which exist within the myocardium, CK-MB is also expressed in skeletal muscle and brain tissue, cTnI is a specific indicator of myocardial injury and an independent predictor for the severity of myocardial injury; however, sensitivity is low using the standard sensitivity assays.…”
Section: Discussionsupporting
confidence: 82%
“…The relationship between cTn and mortality in critically ill patients is not new, 1 , 3 , 4 , 8 , 16 19 but not all published work is in agreement. 20 A limitation of studies using cTnI as a marker is that there are many cTnI assay manufacturers.…”
Section: Discussionmentioning
confidence: 99%
“… 7 This trend is also observed in critically ill children. 8 The mechanism of cTn release in critically ill patients is poorly understood. 9 The major concern when cTn is found to be elevated is whether rupture of a coronary arterial plaque has occurred and if the patient requires urgent coronary angiography and revascularization.…”
mentioning
confidence: 99%
“…Mortality rate increases from 70% to 90% with the presence of myocardial dysfunction in children with sepsis. (2,3) Hemodynamic monitoring is important in diagnosing and treating sepsis. Both invasive and non-invasive monitoring methods can be used in hemodynamic and myocardial dysfunction monitoring in sepsis.…”
Section: Introductionmentioning
confidence: 99%