2023
DOI: 10.29001/2073-8552-2023-38-1-110-117
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Myocardial inotropic response of rats of different ages to extrasystolic exposures in postinfarction cardiosclerosis

Abstract: The age-dependent features of the inotropic response of isolated strips of rat papillary muscles in postinfarction cardiosclerosis were studied. The rhythmic-inotropic response of the myocardium to extrasystolic effects was assessed in sham-operated (SO) rats and rats with established post-infarction cardiosclerosis (PICS) in the age groups of 4, 12, and 24 months (mon). It was shown that the excitability of the sarcoplasmic membrane of cardiomyocytes increases in 12-mon-old SO animals, and decreases in 24-mon… Show more

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