Myocardial Involvement in Patients With Sarcoidosis

Hirose, Yoshiaki; Ishida, Yoshiteru; Hayashida, Kentaro; Maeno, Masakazu; Takamiya, Makoto; Ohmori, Fumio; Miyatake, Kunio; Uehara, Toshiisa; Nishimura, Tsunehiko; Tachibana, T

doi:10.1097/00003072-199406000-00012

Cited by 49 publications

(23 citation statements)

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“…It is believed that reverse redistribution in CS is caused by focal reversible microvascular constriction in coronary arterioles around the granulomas (69). According to the results of a few studies, 99m Tc-sestamibi seems to be superior to 201 Tl in detecting reverse distribution (67,70).…”

Section: Other Radionuclide Imaging Testsmentioning

confidence: 99%

Advanced Imaging of Cardiac Sarcoidosis

2013

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Section: Other Radionuclide Imaging Testsmentioning

confidence: 99%

Advanced Imaging of Cardiac Sarcoidosis

2013

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“…Magnetic resonance imaging and newer echocardiographic techniques have been applied for myocarditis in pilot studies. Nuclear imaging with gallium-167 [33] to detect leukocytes or antimyosin antibodies to detect myocyte necrosis [61] has not been used to diagnose giant cell myocarditis. Because of the rarity and severity of giant cell myocarditis, a highly sensitive non-invasive test would be of great value; however, such a development is…”

Section: Diagnostic Strategymentioning

confidence: 99%

Giant Cell Myocarditis: Diagnosis and Treatment

Cooper

2000

Herz

109

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Giant cell myocarditis is a rare but devastating disease that usually affects young otherwise healthy individuals. Associations with thymoma, inflammatory bowel disease, and a variety of autoimmune disorders have been reported. The rate of death or heart transplantation is approximately 70% at 1 year. Data from a Lewis rat model and from observational human studies suggest that giant cell myocarditis is mediated by T lymphocytes and may respond to treatment aimed at attenuating T cell function. Recent findings from the Giant Cell Myocarditis Registry, a clinical and pathologic database from 63 cases of giant cell myocarditis gathered from 36 medical centers, include the following: The sensitivity of endomyocardial biopsy for giant cell myocarditis for patients who undergo transplantation or autopsy is 82 to 85%. Registry subjects who received cyclosporine in combination with steroid, azathioprine, or muromonab-CD3 have prolonged transplant-free survival (12.6 months vs. 3.0 months for no immunosuppression). Post-transplantation survival is approximately 71% at 5 years despite a 25% rate of giant cell infiltration in the donor heart. To confirm and extend these findings, a randomized trial of immunosuppression including muromonab-CD3, cyclosporine, and steroids is underway.

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“…Uptake of FDG within atherosclerotic plaques in multiple arteries, including the aorta, iliac arteries, and proximal femoral arteries has been reported (Hirose et al, 1994;Libby et al, 2002), and correlation with the CT portion of the examination should be made to confirm that these areas of increased metabolism reside within a vessel (See Fig. 6).…”

Section: Discussionmentioning

confidence: 99%