1988
DOI: 10.1093/oxfordjournals.eurheartj.a062437
|View full text |Cite
|
Sign up to set email alerts
|

Myocardial involvement in systemic lupus erythematosus detected by magnetic resonance imaging

Abstract: Myocardial involvement in systemic lupus erythematosus is commonly found at autopsy but seldom recognized clinically or by routine cardiological investigations. As the magnetic resonance relaxation parameter, T1, is altered by changes in tissue cellularity, we carried out magnetic resonance imaging in 10 patients with systemic lupus erythematosus. Five had active systemic lupus erythematosus when assessed using the lupus activity criteria count. The mean (+/- SD) T1 was 319 +/- 12 in normal volunteers and 321 … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
20
0

Year Published

1991
1991
2013
2013

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 39 publications
(24 citation statements)
references
References 0 publications
4
20
0
Order By: Relevance
“…[1][2][3][4] In a previous study using CMR in SLE patients, only ischemia-like pattern of myocardial LGE was found; however, patients included had cardiovascular symptoms. 18 In contrast, other studies set to interrogate subclinical cardiovascular manifestations demonstrated patchy myocardial LGE patterns consistent with nonischemic regional fibrosis, 8,17 and our findings agree with the latter observation. Because the LGE appearances closely resemble the typical pattern found in patients with chronic stages of viral myocarditis 35 or early idiopathic cardiomyopathy, 36 these findings may represent a sequel to an indolent course of perimyocarditis.…”
Section: Discussionsupporting
confidence: 89%
See 2 more Smart Citations
“…[1][2][3][4] In a previous study using CMR in SLE patients, only ischemia-like pattern of myocardial LGE was found; however, patients included had cardiovascular symptoms. 18 In contrast, other studies set to interrogate subclinical cardiovascular manifestations demonstrated patchy myocardial LGE patterns consistent with nonischemic regional fibrosis, 8,17 and our findings agree with the latter observation. Because the LGE appearances closely resemble the typical pattern found in patients with chronic stages of viral myocarditis 35 or early idiopathic cardiomyopathy, 36 these findings may represent a sequel to an indolent course of perimyocarditis.…”
Section: Discussionsupporting
confidence: 89%
“…We found that patients with SLE have increased myocardial T1 native , and this finding is concordant with a single previous study using T1 mapping in SLE patients. 17 It is widely recognized that LGE can be challenging for visualization of diffuse myocardial process, [20][21][22][23][24] and hence, we used quantification of T1 relaxation in native and postcontrast myocardium to assist with assessment of myocardial involvement. We show that the composite T1 indices λ and ECV are also increased.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Four of the active SLE patients underwent repeat cardiac imaging, which demonstrated normalization of T2 signal abnormalities. Increase in T1 signal intensity of myocardium in a group of patients with active SLE was also reported in an earlier study by Been et al [2].…”
Section: Discussionsupporting
confidence: 84%
“…However, despite being the gold standard for diagnosis, endomyocardial biopsy cannot be used routinely or repeatedly, particularly in asymptomatic patients. Cardiac magnetic resonance (CMR) is sensitive to many of the changes that characterize lupus myocarditis, particularly through T2-weighted imaging (myocardial oedema) [28, 29] and early (EGE) and late (LGE) gadolinium-enhanced CMR [28, 30]. The combination of EGE, LGE, and T2 imaging sequences has been reported to have 76% sensitivity and 95.5% specificity for the detection of myocardial inflammation [28].…”
Section: Assessing Cardiac Involvementmentioning
confidence: 99%