Myocardial longitudinal strain, fitness, and heart failure risk factors in young adults

Arenas, Ivan A.; Podesta, Carlos; Issa, Omar; Lin, Jen‐Wei; Brenes, Juan C.

doi:10.1111/echo.14613

Cited by 5 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, we found a base to apex gradient in LV regional LS abnormalities, with apical segments being less affected. This pattern has already been described in other cardiac diseases such as systemic hypertension [24], and recently reported by our group in a cohort of pediatric patients with previous asymptomatic or mildly symptomatic COVID-19 without MIS-C development [25]. Of interest, other studies on different populations have already demonstrated the prognostic value of GLS [26].…”

Section: Longitudinal Strainsupporting

confidence: 80%

Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children

Sirico

Basso

Reffo

et al. 2021

JCM

View full text Add to dashboard Cite

Multisystem Inflammatory Syndrome in Children (MIS-C) is a known severe condition affecting children previously exposed to SARS-CoV-2. The aim of our study was to describe the early cardiac abnormalities in patients with MIS-C, evaluated by speckle tracking echocardiography (STE) and cardiac MRI (CMR). Clinical, laboratory and microbiological data were measured for all patients. All children underwent standard transthoracic echocardiography, STE with analysis of left ventricle global longitudinal strain (GLS). Seventeen (75%) of the children were evaluated with CMR. Twenty-three patients (13M, 10F) were recruited, mean age was 8.1 ± 4 years. Cardiovascular symptoms were present in 10 (43.5%). Nine children (39.1%) shared Kawasaki Disease-like symptoms. Four patients (17.4%) needed ICU admission. In-hospital survival was 100%. TnI was elevated in 15 (65.2%) and BNP in 20 (86.9%) patients. The median time to STE evaluation was 8 days and to CMR was 18 days after fever onset. Mean LVEF was 59 ± 10%. Coronary dilation was observed in six (26.1%) patients. STE showed a reduced mean LVGLS (−17 ± 4.3%). LGE with a non-ischemic pattern was evident in six out of seventeen patients (35.2%). The elevation of myocardial necrosis markers, the reduction of LVGLS and the presence of LGE on CMR in about a quarter of MIS-C patients supports the hypothesis of a post-viral immune-mediated myocarditis-like pathogenesis.

show abstract

Section: Longitudinal Strainsupporting

confidence: 80%

Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children

Sirico

Basso

Reffo

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…In our study, there is a positive association between the GLS and BMI. Impairment of the LV-EF and GLS by overweight and obesity is also known from other studies [47][48][49]. The parameters of diastolic function are within the normal range in our studied athletes but are significantly reduced in the PCAt.…”

Section: Discussionsupporting

confidence: 86%

Left Ventricular Global Longitudinal Strain as a Parameter of Mild Myocardial Dysfunction in Athletes after COVID-19

Schellenberg

Ahathaller

Matits

et al. 2023

JCDD

View full text Add to dashboard Cite

Whether symptoms during COVID-19 contribute to impaired left ventricular (LV) function remains unclear. We determine LV global longitudinal strain (GLS) between athletes with a positive COVID-19 test (PCAt) and healthy control athletes (CON) and relate it to symptoms during COVID-19. GLS is determined in four-, two-, and three-chamber views and assessed offline by a blinded investigator in 88 PCAt (35% women) (training at least three times per week/>20 MET) and 52 CONs from the national or state squad (38% women) at a median of two months after COVID-19. The results show that the GLS is significantly lower (GLS −18.53 ± 1.94% vs. −19.94 ± 1.42%, p < 0.001) and diastolic function significantly reduces (E/A 1.54 ± 0.52 vs. 1.66 ± 0.43, p = 0.020; E/E’l 5.74 ± 1.74 vs. 5.22 ± 1.36, p = 0.024) in PCAt. There is no association between GLS and symptoms like resting or exertional dyspnea, palpitations, chest pain or increased resting heart rate. However, there is a trend toward a lower GLS in PCAt with subjectively perceived performance limitation (p = 0.054). A significantly lower GLS and diastolic function in PCAt compared with healthy peers may indicate mild myocardial dysfunction after COVID-19. However, the changes are within the normal range, so that clinical relevance is questionable. Further studies on the effect of lower GLS on performance parameters are necessary.

show abstract

“…There was a positive association between GLS and BMI in our study. Impairment of LV-EF and GLS by overweight and obesity is also known from other studies (39)(40)(41). Parameters of diastolic function were within the normal range in our studied athletes but were significantly reduced in PCAt.…”

Section: Initial Symptoms and Correlation Analysis With Gls And Grssupporting

confidence: 55%

Left ventricular global longitudinal strain as a parameter of mild myocardial dysfunction in athletes after COVID-19

Schellenberg

Ahathaller

Matits

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Whether impaired left ventricular (LV) function contributes to persistent cardiopulmonary symptoms or decreased exercise capacity after COVID-19 remains unclear. The aim of this prospective study was to determine differences in LV global longitudinal strain (GLS) between athletes who did not have a history of LV dysfunction but had a positive COVID-19 test (PCAt) and healthy control (CON) athletes and relate them to symptoms during COVID-19. Methods We performed 151 transthoracic echocardiographies in our high-performance laboratory. GLS was determined in four-, two-, and three-chamber views and assessed offline by a blinded investigator in 88 PCAt (35% women) at a median of two months after COVID-19 who trained at least three times per week with more than 20 MET per week and 52 CONs from the German national squad (38% women). Results GLS was significantly lower (GLS -18.53 ±1.94% vs. -19.94±1.42%, p<0.001) and diastolic function significantly reduced (E/A 1.54±0.52 vs. 1.66±0.43, p=0.020; E`l 0.15±0.04 vs. 0.17±0.04, p=0.009; E/E'l 5.74±1.74 vs. 5.22±1.36, p=0.024) in PCAt. There was no association between GLS and acute symptoms like resting dyspnea, exertional dyspnea during or after COVID-19, palpitations, chest pain or increased resting heart rate. However, there was a trend toward lower GLS in PCAt with subjectively perceived performance limitation (p=0.054). Conclusions In a cohort of athletes at a median two months after COVID-19, significantly lower GLS and diastolic function were observed, suggesting mild myocardial dysfunction. GLS could be used as a screening element during return-to-sport examinations.

show abstract

Myocardial longitudinal strain, fitness, and heart failure risk factors in young adults

Cited by 5 publications

References 31 publications

Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children

Early Echocardiographic and Cardiac MRI Findings in Multisystem Inflammatory Syndrome in Children

Left Ventricular Global Longitudinal Strain as a Parameter of Mild Myocardial Dysfunction in Athletes after COVID-19

Left ventricular global longitudinal strain as a parameter of mild myocardial dysfunction in athletes after COVID-19

Contact Info

Product

Resources

About