Myocardial Necrosis Following Elective Cardiac Arrest Induced With Potassium Citrate

Does cold blood cardioplegia solution cause deterioration in clinical pulmonary function following coronary artery bypass graft surgery?

“…This form of reversible myocardial electromechanical arrest is, however, via a solution that is known to be toxic to the cells it comes into contact with, the myocytes and the endothelium of both the heart and lungs. [1][2][3][4] Cardioplegia solutions, in particular crystalloid solutions, have been implicated in inducing endothelial dysfunction and altered vascular responsiveness. [5][6] Cold blood cardioplegia has also been implicated in amplifying the inflammatory process through transient plasma iron overload derived from oxidatively damaged haemoglobin by 'activated' neutrophils.…”