2012
DOI: 10.1096/fasebj.26.1_supplement.209.4
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Myocardial Notch Signaling Reprograms Cardiomyoctes to a Conduction‐Like Phenotype

Abstract: Notch signaling has previously been shown to play an essential role in regulating cell fate decisions in many systems. We hypothesized that Notch may be involved in directing the progressive lineage restriction of cardiomyocytes into specialized conduction cells. In murine hearts where Notch signaling is activated within the myocardium from early development onwards, Notch promotes a conduction‐like phenotype as evidenced by ectopic expression of conduction system‐specific genes, as well as cell autonomous cha… Show more

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