Myocardial potency of Caesalpinia bonducella Linn. on doxorubicin induced myocardial infarction in albino rats

Abstract

Objective: Caesalpinia bonducella L. is well known and extremely valuable herb in ayurvedic system of medicine. The present study is aimed to design the evaluation of aqueous extract of Caesalpinia bonducella L. on doxorubicin induced myocardial infarction in wistar strains of albino rats of both sex. Materials and methods: The experimental animals are divided in to 5 groups of 6 animals each. Group I (Normal Control), Group II (Negative Control, 2.5 mg/kgbw of Doxorubicin i.p.), Group III (2.5 mg/kgbw of Doxorubicin i.p.) + AECB (150 mg/kgbw), Group IV (2.5 mg/kgbw of Doxorubicin i.p.) + AECB (300 mg/kgbw), Group V (2.5 mg/kgbw of Doxorubicin i.p.) + standard drug (Propranolol 5 mg/kgbw). Doxorubicin induced myocardial infarction was confirmed by disturbances in levels of cardiac markers (Lactate Dehydrogenase, Troponin-T, Creatine Kinase-MB Isoenzyme, Creatine Phosphokinase), nucleic acid contents (DNA and RNA), Challenged levels of Membrane bound enzymes such as Na+/K + ATPase, Ca2 + ATPase and Mg2 + ATPase, Decreased tissue protein and altered lipid profile markers. Results: Doxorubicin induced rats significantly showed increase in the activities of LDH, CK-MB, CPK, Troponin-T, nucleic acids, membrane bound enzymes, lipid profiles and decrease in the serum HDL. Treatment with AECB simultaneously at two different doses such as 150 mg/kg bw, 300 mg/kg bw prevented the leakage of myocardium markers and altered the levels of Protein, DNA, RNA and membrane bound enzymes. The AECB prevented the altered variations in Cholesterol, Triacylglycerols, Phospholipids and Free Fatty Acids. This extract also brought back the levels of Lipoproteins like HDL, LDL and VLDL which were varied in disease control animals. Conclusion: The present study concludes that AECB is effective in controlling the cardiac markers and lipid levels which could be due to its ability to maintain the membrane stability and repair the myocardial damage.

Cardioprotective Effect of Quercetin and Sitagliptin in Doxorubicin-Induced Cardiac Toxicity in Rats

“…Concerning the effect of DOX on lipid profile and atherogenic indices; the study revealed that DOX increased TG, LDL, and total cholesterol with no significant effect on HDL; this finding is in tune with other studies. 32,38,39 The combination of QC and STN was effective in attenuating the levels of LDL and TG. Quercetin alone was effective in ameliorating cholesterol levels.…”

Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma

“…Nayagam (2019) [ 48 ] reported that doxorubicin-associated cardiotoxicity due to the accumulation of circulating free fatty acids (FFAs), leading to blockage of the coronary arteries. Cocoa ameliorates the lipid profile in dyslipidaemic conditions in the complex pathogenesis of lipid and glucose metabolism [ 49 ].…”

Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy

“…Similarly, an increase in these marker enzymes has been previously reported in DOX-treated animals attributable to DOX-induced cardiac damage. [65][66][67] Regarding sensitivity and specificity, cTns, including cTnI, are superior to cardiac muscle enzymes in the identification of myocardial injury. [68] Previously, it has been shown that levels of cTnI are likely to be used for monitoring the extent of DOX-induced cardiac damage in rats.…”

“…Similarly, an increase in these marker enzymes has been previously reported in DOX‐treated animals attributable to DOX‐induced cardiac damage. [ 65–67 ]…”