Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits

Martins, Antônio Sérgio; Silva, Marcos Augusto de Moraes; Padovani, Carlos Roberto; Matsubara, B.B.; Braile, Domingo Marcolino; Catâneo, Antônio José Maria

doi:10.1590/s0102-86502007000100008

Cited by 4 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several solutions have been described for organ transplants [17][18][19]. The solution used by us was described by Martins et al [20]. It is routinely used in our department as cardioplegic solution in conventional cardiac surgery, and we are not aware of its use as a solution for preserving organs for transplant.…”

Section: Discussionmentioning

confidence: 99%

Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia

Lavagnoli

Severino

Vilarinho

et al. 2012

Revista Brasileira De Cirurgia Cardiovascular

Self Cite

View full text Add to dashboard Cite

Fatores associados à sobrevida em pacientes submetidos a transplante cardíaco utilizando microcardioplegia sanguínea retrógrada Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia Abstract Background: Several techniques and cardioplegic solutions have been used for heart preservation during transplant procedures. Unfortunately, there is a lack of ideal method for myocardial preservation in the clinical practice. The use of retrograde cardioplegia provides continuous infusion of cardioplegic solution during the graft implantation. This strategy may provide better initial recovery of the graft. The objective of this study is to describe the experience of a single center where all patients received the same solution for organ preservation and were subjected to continuous retrograde blood microcardioplegia during implantation of the graft and to evaluate factors associated to early and late mortality with this technique.Methods: This is a retrospective, observational and descriptive study of a single center.Results: During the study period were performed 35 heart transplants. Fifteen (42.9%) patients were in cardiogenic shock. The probability of survival was 74.8±7.8%, 60.4±11.3% and 15.1±13.4% at 1 year, 5 years and 10 years of follow-up, respectively. The median survival time was 96.6 months.Conclusion: The use of myocardial protection with retrograde cardioplegic solution may reduce the risks associated morbidity due to cold ischemia time during the heart transplant, and we suggest that this benefit may be even greater in cases of cold ischemia time longer ensuring protection to the myocardium.Descriptors: Heart transplantation. Transplantation. Heart arrest, induced. Myocardium. Follow-up studies. ResumoIntrodução: Uma grande variedade de técnicas e soluções é utilizada na preservação do coração durante o transplante, o que demonstra a falta de método ideal na prática clínica. A 348Lavagnoli CFR, et al. -Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia Bras Cir Cardiovasc 2012;27(3):347-54 INTRODUCTION A variety of techniques and solutions are used in the preservation of the heart during transplantation, demonstrating the lack of ideal method in clinical practice [1]. RevIn the present day, where the number of donors is not enough, in addition to the increase of high-risk recipients on the waiting list, every effort should be made towards better organ preservation. A better organ preservation leads to lower graft dysfunction and promotes better late outcomes after transplantation [2,3].The use of retrograde blood cardioplegia has been described in several studies in the literature. There is no consensus whether this strategy promotes adequate myocardial protection [4]. Its use for the administration of blood cardioplegia during implantation is frequently reported in the literature. This strategy of cardioplegia administration allows for continuous perfusion o...

show abstract

Section: Discussionmentioning

confidence: 99%

Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia

Lavagnoli

Severino

Vilarinho

et al. 2012

Revista Brasileira De Cirurgia Cardiovascular

Self Cite

View full text Add to dashboard Cite

show abstract

“…(11) yaptıkları deneysel çalışmada, kan kardiyoplejisinin ventriküler fonksiyonu daha iyi koruduğunu göstermişlerdir. Flack ve ark.…”

unclassified

Retrospective Evaluation of Different Cardioplegic Solutions in Open Heart Surgery

Tapar¹,

Kaya²,

Süren³

et al. 2012

GKDA Derg

View full text Add to dashboard Cite

show abstract

“…A constant flow of tepid or warm oxygenated blood is infused through the aorta and/or coronary sinus while the cardioplegic components are added in-line just before reaching the patient. A miniplegic formulation is commercially available in Brazil, (Braile Biomédica, São José do Río Preto, Brazil) (1,2). This technique requires a formulation for cardioplegic induction and another for cardioplegic maintenance ( Table 1 ).…”

mentioning

confidence: 99%

Pig Heart Preservation with Antegrade Intracellular Crystalloid versus Antegrade/Retrograde Miniplegia

Portilla-de Buen,

Leal,

García-Martínez

et al. 2011

J Extra Corpor Technol

View full text Add to dashboard Cite

Both histidine-tryptophan-ketoglutarate (HTK) solution and Braile miniplegia are commercially available and used with high success. The objective of this work was to compare the effects of both strategies in an animal model. Twelve pigs were divided into control, HTK, or Braile groups using a model of controlled global cardiac ischemia/reperfusion under cardiopulmonary bypass with 1 hour heart ischemia followed by 2 hour reperfusion. No significant differences were found over time or between groups for heart rate, arrhythmia, number of defibrillations required, blood gases, myocardial lactate production, myocardial oxygen consumption, nor coronary flow index. The Braile strategy was associated with a lower 120 minute postreperfusion coronary vascular resistance with higher water content, leukocyte infiltration, and oxidative damage compared with controls. Drainage of HTK solution to the venous return was followed by higher potassium and lower sodium blood concentrations. One-hour heart preservation with HTK or Braile systems followed by 2 hour reperfusion both allow for acceptable preservation of the healthy pig myocardium. Maneuvers such as leukocyte filtration or hemofiltration may further improve these conditions.

show abstract

Myocardial protection by continuous, blood, antegrade-retrograde cardioplegia in rabbits

Cited by 4 publications

References 10 publications

Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia

Associated factors with survivals in patients undergoing orthotopic heart transplant using retrograde blood microcardioplegia

Retrospective Evaluation of Different Cardioplegic Solutions in Open Heart Surgery

Pig Heart Preservation with Antegrade Intracellular Crystalloid versus Antegrade/Retrograde Miniplegia

Contact Info

Product

Resources

About