Myocardial Revascularization in Patients Receiving Long-Term Propranolol Therapy

Kirsh, Marvin M.; Behrendt, Douglas M.; Jackson, A. P. F.; Dhadphale, P. R.; Alseri, S.; Brymer, James F.; Orringer, Mark B.; Sloan, Herbert

doi:10.1016/s0003-4975(10)63503-5

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Withdrawal Syndrome1

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Cited by 26 publications

(1 citation statement)

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“…In their study, the risks of withdrawal were obvious, five of 143 patients developing myocardial infarction within 48 h of drug withdrawal. More recently, several authors have demonstrated the safety of continuing beta-adrenoceptor antagonist therapy to within 1 -5 h of coronary surgery (Kirsh et al, 1978;Kopriva, Guinazu and Barash, 1978).…”

Section: Withdrawal Syndromementioning

confidence: 99%

Alpha-and Beta-Adrenoceptor Antagonists

Foëx

1984

British Journal of Anaesthesia

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Section: Withdrawal Syndromementioning

confidence: 99%

Alpha-and Beta-Adrenoceptor Antagonists

Foëx

1984

British Journal of Anaesthesia

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Continued Propranolol Administration Following Coronary Bypass Surgery

Abel¹,

Gelder²,

Pores³

et al. 1983

Arch Surg

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Pindolol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses, and Adverse Effects

Golightly¹

1982

Pharmacotherapy

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Pindolol is a new noncardioselective beta adrenergic blocking agent with intrinsic sympathomimetic activity. In the treatment of mild to moderate hypertension, pindolol provides effective control of blood pressure in a large majority of patients when administered alone or, more commonly, when combined with a thiazide diuretic. Pindolol is approximately as effective as propranolol in the therapy of hypertension, but in some crossover trials central nervous system side effects were more frequent with pindolol. A "ceiling effect" may be observed as dosages are titrated upward above approximately 20 to 30 mg per day, such that further blood pressure reductions may not be achievable. Some patients will exhibit a paradoxical increase in blood pressure with an increase in dosage. In patients who respond to modest doses of pindolol, twice or even once daily dosing is often adequate. This prolonged duration of hypotensive activity, while not suggested by the kinetics of this or similar drugs, is probably common to most beta blockers. Investigations in small numbers of patients with angina pectoris have reported variable but generally beneficial results with pindolol.

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Myocardial Revascularization in Patients Receiving Long-Term Propranolol Therapy

Cited by 26 publications

References 12 publications

Alpha-and Beta-Adrenoceptor Antagonists

Alpha-and Beta-Adrenoceptor Antagonists

Continued Propranolol Administration Following Coronary Bypass Surgery

Pindolol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses, and Adverse Effects

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