Myocardial salvage after ST-segment-elevation myocardial infarction: comparison between prasugrel and clopidogrel in the presence or absence of high-residual platelet reactivity

Yoshida, Ruka; Takagi, Kensuke; Ishii, Hideki; Morishima, Itsuro; Tanaka, Akihito; Morita, Yasuhiro; Kanzaki, Yasunori; Nagai, Hiroto; Watanabe, Naoki; Furui, Koichi; Shibata, Naoki; Yoshioka, Naoki; Yamauchi, Ryota; Komeyama, Shotaro; Sugiyama, Hiroki; Tsuboi, Hideyuki; Murohara, Toyoaki

doi:10.1007/s12350-019-01852-3

Cited by 4 publications

(5 citation statements)

References 35 publications

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“…Clopidogrel could significantly improve atherosclerosis and myocardial infarction and had a good antiplatelet effect [ 10 ]. Creatine kinase-MB (CK-MB) was a serum enzyme index for detecting myocardial infarction.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model

Wang

et al. 2022

BioMed Research International

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In order to investigate the effects of clopidogrel rehabilitation on the levels of cardiac protein kinase C (PKC), cardiac heat shock protein 70 (HSP70), and cardiac index (CI) in rats with myocardial ischemia-reperfusion injury (MIRI), sixty Wistar rats are randomly divided into three groups (sham operation group, model group, and clopidogrel group), with 20 rats in each group. The clopidogrel group is given clopidogrel by gavage, and the sham operation group and the model group are given the same amount of normal saline by gavage. The experimental results show that compared with the model group, the clopidogrel group has clear horizontal lines and cell edema. The myocardial infarction rate, creatine kinase-MB (CK-MB), and malondialdehyde (MDA) of the model group and clopidogrel group in the control sham operation group significantly increase.

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Section: Related Workmentioning

confidence: 99%

[Retracted] Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model

Wang

et al. 2022

BioMed Research International

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“…Molecular imaging refers to visual detection of physiological and pathological processes at the cellular or molecular level to reveal the health status of tissues or organs through molecular information. 1,2 Since molecular changes often precede anatomical transition during disease progression, molecular imaging has attracted increasing attention as a more sensitive means than traditional anatomical imaging that has been widely used in the clinic, which stimulates the development of powerful imaging techniques, such as single photo emission computed tomography (SPECT) 3 and positron emission tomography (PET), 4 as well as the evolution of traditional imaging techniques, e.g., magnetic resonance imaging (MRI). 5 MRI, which is a nonionizing imaging technique with high penetration, is one of the most powerful diagnostic tools for diseases.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-Based Activatable MRI Probes for Disease Imaging and Monitoring

Fan

Chen

Zheng

et al. 2023

Chemical & Biomedical Imaging

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Traditional diagnosis relies on identifying anatomical abnormality, which offers a stage for various anatomical imaging techniques, such as X-ray computed tomography (CT), ultrasonic imaging, and magnetic resonance imaging (MRI). The good capacity of providing anatomical details, especially for soft tissues, popularizes the clinical use of MRI. However, as the understanding of various diseases reaches the molecular level, it is gradually accepted that molecular anomaly often precedes anatomical abnormality. Therefore, molecular imaging, which is aimed at gathering various molecular information in organisms via imaging, starts to gain momentum. Unfortunately, traditional MRI is not capable of molecular imaging. As a result, there is an urgent demand for probes that enable MRI to "see" molecules. A promising design strategy for these probes is to elicit a signal change triggered by the presence of molecular targets, i.e. activation. Benefiting from the rapid development of nanotechnology, a number of nanoparticle-based activatable MRI probes have been developed for molecular imaging. This review summarizes recent advances of activatable MRI nanoprobes for imaging pathological characteristics of cancer, inflammation, and neurodegenerative diseases, with a focus on the design strategies and applications of these probes. In addition, the prospects and challenges of activatable MRI nanoprobes are also discussed.

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“…9 It has been demonstrated that the size of AAR assessed by 123 I-BMIPP imaging at 7 days after myocardial infarction is similar to perfusion defect evaluated by SPECT perfusion imaging performed at cath lab time, with the advantage to being able to schedule the examination when the patient is more stable. 10 In the present issue of the Journal, Yoshida et al 11 compared the effect of prasugrel and clopidogrel on myocardial salvage, assessed by 123 I-BMIPP imaging at 7 days after the reperfusion therapy and 99m-Tc-tetrofosmin SPECT 3 months after revascularization.…”

mentioning

confidence: 99%

“…Yoshida et al 11 investigation has the merit to bring to the fore the discussion on the usefulness of platelet function tests, particularly in patients in whom DAPT is mandatory. It has been demonstrated that a high ontreatment platelet reactivity is associated with ischemic events while a low on-treatment platelet reactivity is associated with bleeding.…”

mentioning

confidence: 99%

“…It has been demonstrated that a high ontreatment platelet reactivity is associated with ischemic events while a low on-treatment platelet reactivity is associated with bleeding. 19 In the current study, 11 platelet function test was performed using a whole blood aggregometer based on the screen filtration pressure method. However, the prevalence of high and low-platelet reactivity may differ significantly between assays, and several laboratorybased methods, (Light Transmission Aggregometry, Multiple Electrode Aggregometry, Platelet Function Analyser (PFA)-100, Vasodilator-Stimulated Phosphoprotein (VASP) assay), and point-of-care or nearpatient-based assay (VerifyNow, Multiplate, Thromboelastography) have been proposed.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Radionuclide imaging of jeopardized myocardium: From the beginning of the race to the finish line

Gaudieri

Nappi

Petretta

2021

Journal of Nuclear Cardiology

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Myocardial salvage after ST-segment-elevation myocardial infarction: comparison between prasugrel and clopidogrel in the presence or absence of high-residual platelet reactivity

Cited by 4 publications

References 35 publications

[Retracted] Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model

[Retracted] Effects of Clopidogrel Rehabilitation on Cardiac Protein Kinase C, Cardiac Heat Shock Protein 70, and CI in MIRI Rat Model

Nanoparticle-Based Activatable MRI Probes for Disease Imaging and Monitoring

Radionuclide imaging of jeopardized myocardium: From the beginning of the race to the finish line

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