Myocardial scintigraphy

Alexander, C.; Oberhausen, E.

doi:10.1016/s0001-2998(95)80026-3

Cited by 14 publications

(5 citation statements)

References 5 publications

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“…During the following years, the results were confirmed by others [ 39 – 42 ]. During more than 20 years, antimyosin scans remained an important cornerstone in the diagnosis of myocarditis [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive imaging in the diagnosis of acute viral myocarditis

et al. 2009

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Autopsy series of consecutive cases have demonstrated an incidence of myocarditis at approximately 1-10%; on the contrary, myocarditis is seriously underdiagnosed clinically. In a traditional view, the gold standard has been myocardial biopsy. However, it is generally specific but invasive and less sensitive, mostly because of the focal nature of the disease. Thus, non-invasive approaches to detect myocarditis are necessary. The traditional diagnostic tools are electrocardiography, laboratory values, especially troponin T or I, creatine kinase and echocardiography. For a long period, nuclear technique with indium-111 antimyosin antibody has been used as a diagnostic approach. In the last years, the use of this technique has declined because of radiation exposure and 48-h delay in obtaining imaging after injection to prevent blood pool effect. Thus, a non-invasive diagnostic approach without radiation and online image availability has been awaited. Cardiac magnetic resonance imaging has these promising characteristics. With this technique, it is possible to analyse inflammation, oedema and necrosis in addition to functional parameters such as left ventricular function, regional wall motion and dimensions. Thus, cardiovascular magnetic resonance imaging has emerged as the most important imaging tool in the diagnostic procedure and the review focus on this field. But there are also advances in echocardiography and computer tomography, which are described in detail.

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Section: Introductionmentioning

confidence: 99%

Non-invasive imaging in the diagnosis of acute viral myocarditis

et al. 2009

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“…Myocardial scintigraphy with inflammation-sensitive radioisotopes has been used to diagnose acute myocarditis [ 71 ]. The isotopes that have been used in the workup of acute myocarditis include gallium-67 (Ga-67), indium-111 (In-111) monoclonal antimyosin antibody, and technetium-99m (Tc-99m)-labeled methoxy-isobutyl isonitrile (MIBI) single-photon emission computed tomography (SPECT), and technetium-99m depreotide [ 71 ].…”

Section: Role Of Imaging Modalities In Myocarditismentioning

confidence: 99%

A Review of the Role of Imaging Modalities in the Evaluation of Viral Myocarditis with a Special Focus on COVID-19-Related Myocarditis

et al. 2022

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Viral myocarditis is inflammation of the myocardium secondary to viral infection. The clinical presentation of viral myocarditis is very heterogeneous and can range from nonspecific symptoms of malaise and fatigue in subclinical disease to a more florid presentation, such as acute cardiogenic shock and sudden cardiac death in severe cases. The accurate and prompt diagnosis of viral myocarditis is very challenging. Endomyocardial biopsy is considered to be the gold standard test to confirm viral myocarditis; however, it is an invasive procedure, and the sensitivity is low when myocardial involvement is focal. Cardiac imaging hence plays an essential role in the noninvasive evaluation of viral myocarditis. The current coronavirus disease 2019 (COVID-19) pandemic has generated considerable interest in the use of imaging in the early detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related myocarditis. This article reviews the role of various cardiac imaging modalities used in the diagnosis and assessment of viral myocarditis, including COVID-19-related myocarditis.

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“…Technetium 99 m sestamibi ([ 99m Tc]Tc-MIBI) is a typical radiotracer used in single-photon emission computed tomography (SPECT) to investigate myocardial perfusion (Alexander and Oberhausen, 1995). Generally, the spatial resolution of SPECT is much lower than that of PET.…”

Section: Mitochondrial Activitymentioning

confidence: 99%

Recent developments on the application of molecular probes in multiple myeloma: Beyond [18F]FDG

Zhang

Shang

et al. 2022

Front. Bioeng. Biotechnol.

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Multiple myeloma (MM) is a neoplastic plasma cell proliferative disorder characterized by various osteolytic bone destruction as a radiological morphological marker. Functional imaging, particularly nuclear medicine imaging, is a promising method to visualize disease processes before the appearance of structural changes by targeting specific biomarkers related to metabolism ability, tumor microenvironment as well as neoplastic receptors. In addition, by targeting particular antigens with therapeutic antibodies, immuno-PET imaging can support the development of personalized theranostics. At present, various imaging agents have been prepared and evaluated in MM at preclinical and clinical levels. A summary overview of molecular functional imaging in MM is provided, and commonly used radiotracers are characterized.

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Myocardial scintigraphy

Cited by 14 publications

References 5 publications

Non-invasive imaging in the diagnosis of acute viral myocarditis

Non-invasive imaging in the diagnosis of acute viral myocarditis

A Review of the Role of Imaging Modalities in the Evaluation of Viral Myocarditis with a Special Focus on COVID-19-Related Myocarditis

Recent developments on the application of molecular probes in multiple myeloma: Beyond [18F]FDG

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