Myocardial Stimulation with Ultrashort Duration Current Pulses

Pearce, John A.; Bourland, J. D.; Neilsen, W.; Geddes, L. A.; Voelz, M.

doi:10.1111/j.1540-8159.1982.tb02191.x

Cited by 61 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lowest energy requirement for electrical stimulation of the heart using rectangular waveforms, therefore, occurs when the pulse duration approximates the chronaxie time. 20 Animal and human studies have shown a similar strength-duration relationship for defibrillation using a monophasic truncated exponential waveform 17,21,22 and phase 1 of biphasic truncated exponential defibrillation. 11,12,17,23 A pulse duration between 2 and 4 ms has been observed to yield a defibrillation energy minima for monophasic shocks and phase 1 of biphasic shocks.…”

Section: Discussionmentioning

confidence: 92%

Prospective Randomized Comparison of 50%/50% Versus 65%/65% Tilt Biphasic Waveform on Defibrillation in Humans

Sweeney

Volosin

Swerdlow

et al. 2001

Pacing Clinical Electrophis

View full text Add to dashboard Cite

It is unknown if there is a single optimal biphasic waveform for defibrillation. Biphasic waveform tilt may be an important determinant of defibrillation efficacy. The purpose of this study was to compare acute defibrillation success with a three-electrode configuration in humans using 50%/50% versus 65%/65% tilt truncated exponential, biphasic waveforms delivered through a 110-microF capacitor. Acute DFTs for biphasic waveforms with 50%/50% versus 65%/65% tilt were measured in random order in 60 patients using a binary search method. The electrode configuration consisted of a RV coil as the cathode, and a SVC coil plus a pectoral active can emulator (CAN) as the anode. The waveforms were derived from an external voltage source with 110-microF capacitance, and the leading edge voltage of phase 2 was equal to the trailing edge voltage of phase 1. Stored energy DFT (9.2 +/- 5.7 [50%/50%] vs 10.8 +/- 6.4 [65%/65%] J, P = 0.007), current DFT (10.9 +/- 4.0 [50%/50%] vs 12.0 +/- 4.4 [65%/65%] A, P = 0.002) and voltage DFT (391 +/- 118 [50%/50%] vs 424 +/- 128 [65%/65%] V, P = 0.004) were significantly lower for the 50%/50% tilt waveform versus the 65%/65% tilt waveform using this three-electrode configuration and a 110-microF capacitor. For an RV(-)/SVC plus CAN(+) electrode configuration and a 110-microF capacitor, a 50%/50% tilt biphasic waveform results in a 15% reduction in energy DFT, 9% reduction in current DFT, and 8% reduction in voltage DFT versus a 65%/65% tilt biphasic waveform.

show abstract

Section: Discussionmentioning

confidence: 92%

Prospective Randomized Comparison of 50%/50% Versus 65%/65% Tilt Biphasic Waveform on Defibrillation in Humans

Sweeney

Volosin

Swerdlow

et al. 2001

Pacing Clinical Electrophis

View full text Add to dashboard Cite

show abstract

“…After verification of the electrogram measurement, the students will derive the electrical current strength-duration curve using the procedures outlined in [3]. Briefly, the tissue will be excited with rectangular pulses of set duration using a commercial tissue stimulator (WPI IsoStim A320 Isolated Pulse Generator.)…”

Section: Module III -Cardiac Anatomy and Electrophysiologymentioning

confidence: 99%

A hands-on course teaching bioinstrumentation through the design and construction of a benchtop cardiac pacemaker

Bouchard

Downs

Jangraw

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

View full text Add to dashboard Cite

We have developed a bioinstrumentation course that emphasizes practical application of engineering and biological concepts by having students focus on the development of a single biomedical device: a cardiac pacemaker. In creating their benchtop pacemaker, students learn about and design sensing circuitry, data acquisition and processing code, control system algorithms, and stimulation electronics. They also gain an understanding of cardiac anatomy and electrophysiology. The separate elements of the pacemaker created throughout the semester will be repeatedly tested, re-designed, and integrated with one another, culminating in an emulated pacemaker whose efficacy will be tested on North American bullfrogs. It is hypothesized that the hands-on learning in this course, coupled with the practical application of concepts in the context of a single biomedical device, will enhance students' skills in bioinstrumentation design.

show abstract

“…(All animal procedures are conducted with approval from Columbia University's Institutional Animal Care and Use Committee.) The students test their electrogram measurement circuitry from the first module, then derive the empirical electrical current strength-duration curve [19]. These data inform the stimulation circuitry created in Module V.…”

Section: B Course Modulesmentioning

confidence: 99%

Bioinstrumentation: A Project-Based Engineering Course

et al. 2016

View full text Add to dashboard Cite

This paper presents the development, implementation, and assessment of a project-based Bioinstrumentation course. All course lectures and hands-on laboratory activities are related to a central project theme: a cardiac pacemaker. The students create a benchtop cardiac pacemaker by applying instrumentation knowledge acquired in the course to each stage of device development. This approach emphasizes both conceptual and practical student learning: The students must apply theory learned in the course to create their devices. Indirect and direct assessment performed with respect to the major course objective demonstrated that course participants were able to successfully design, construct, and test a bioinstrumentation system. The students perceived a marked increase in their instrumentation knowledge, objectively corroborated by their performance on specific exercises related to the creation of their benchtop pacemakers. The outcomes of the course development presented here, along with the course structure and pedagogical methodology, may enhance engineering education by acting as a guideline for the creation of courses in which a central project theme is used as a platform for concept instruction.Index Terms-Bioinstrumentation, biomedical electronics, biomedical engineering education, biomedical measurement, project-based learning.

show abstract

Myocardial Stimulation with Ultrashort Duration Current Pulses

Cited by 61 publications

References 10 publications

Prospective Randomized Comparison of 50%/50% Versus 65%/65% Tilt Biphasic Waveform on Defibrillation in Humans

Prospective Randomized Comparison of 50%/50% Versus 65%/65% Tilt Biphasic Waveform on Defibrillation in Humans

A hands-on course teaching bioinstrumentation through the design and construction of a benchtop cardiac pacemaker

Bioinstrumentation: A Project-Based Engineering Course

Contact Info

Product

Resources

About