“…Performance evaluation of these software packages is based mainly on the "one time point" global and segmental strain values, e.g. [40,42,43] Similarly, multicenter studies, such as Marwick et al, [2] and meta-analysis reports, such as, [41,46] which usually influence the clinical guidelines and define the normal and abnormal ranges of parameters, as well as clinical decisions, are also based on these "one time point" landmarks. In addition, many other clinical publications, [44,45] have investigated the potential of using such clinical strain landmarks, in addition to or instead of the conventional clinical parameters (such as ejection fraction, end systolic and end diastolic left ventricle areas/volumes, etc.).…”