Myocardial tissue engineering: Fundamentals and future

Chandrasekhar, Soumya K.; Thankam, Finosh G.; Ouseph, Joshi C.; Agrawal, Devendra K.

doi:10.1016/b978-0-12-824064-9.00028-9

Cited by 2 publications

(4 citation statements)

References 62 publications

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“…TE therapies for the treatment of post-MI cardiac tissue injury may also be delivered in the form of a cell sheet construct. In any case, delivery of appropriate cell types in a more rigid medium, compared to direct cell infusion, might address issues with cell engraftment and retention in the area, a problem frequently encountered with cell therapies [ 147 , 148 ].…”

Section: Stem and Progenitor Cell Therapies For Ischemic Heart Diseas...mentioning

confidence: 99%

To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease

Stougiannou,

Christodoulou,

Dimarakis

et al. 2024

CIMB

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Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects. Different stem cell (SC) types have been employed in studies of infarcted myocardium, both in animal models of myocardial infarction (MI) as well as in clinical studies of MI patients, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), Muse cells, multipotent stem cells such as bone marrow-derived cells, mesenchymal stem cells (MSCs) and cardiac stem and progenitor cells (CSC/CPCs). These have been delivered as is, in the form of cell therapies, or have been used to generate tissue-engineered (TE) constructs with variable results. In this text, we sought to perform a narrative review of experimental and clinical studies employing various stem cells (SC) for the treatment of infarcted myocardium within the last two decades, with an emphasis on therapies administered through thoracic incision or through percutaneous coronary interventions (PCI), to elucidate possible mechanisms of action and therapeutic effects of such cell therapies when employed in a surgical or interventional manner.

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Section: Stem and Progenitor Cell Therapies For Ischemic Heart Diseas...mentioning

confidence: 99%

To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease

Stougiannou,

Christodoulou,

Dimarakis

et al. 2024

CIMB

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“…78 1.4 | Polyurethane as a scaffold biomaterial for CTE Polyurethane (PU), a class of biodegradable materials, is vastly used for cardiovascular TE applications. 2 These synthetic polymers have received particular attention owing to their exciting properties, such as long-lasting durability, superior biocompatibility, good mechanical strength, good fatigue resistance, and processability. 79,80 PUs displayed a long degradation time that is a hindrance for usage in CTE.…”

Section: Polycaprolactonementioning

confidence: 99%

“…Cardiovascular diseases are the leading cause of mortality worldwide 1 . Myocardial infarction (MI) is permanent and irreversible destruction and death of a part of the heart muscle, which results from reduced blood flow and lack of oxygen to an area of the heart, and causes thousands of deaths each year 2 . According to the literature, the heart has limitations in terms of its ability to reconstruct 3 .…”

Section: Introductionmentioning

confidence: 99%

“…1 Myocardial infarction (MI) is permanent and irreversible destruction and death of a part of the heart muscle, which results from reduced blood flow and lack of oxygen to an area of the heart, and causes thousands of deaths each year. 2 According to the literature, the heart has limitations in terms of its ability to reconstruct. 3 Presently, heart transplantation and surgery, despite several disadvantages, are the only treatment option to prolong the life of patients.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable functional macromolecules as promising scaffolds for cardiac tissue engineering

Saghebasl

Akbarzadeh

Gorabi

et al. 2022

Polymers for Advanced Techs

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Cardiovascular diseases, the major international health problem and the leading cause of death worldwide have been increasing in recent years due to population aging and lifestyle changes. Loss of cardiac muscle function after myocardial damage is one of the most critical challenges in cardiovascular medicine that has not yet been overcome. Tissue engineering (TE) has emerged as a promising therapeutic approach in modern medicine, targeting the substitution of damaged tissue with functional tissue grown inside an artificial scaffold. Great efforts have been made toward the construction of tissue engineering scaffolds that paved the way for extracellular matrix (ECM)-like biomaterial. In cardiac tissue engineering, key parameters must be determined to select the ideal biomaterial, such as biocompatibility, conductivity, mechanical features, degradation and swelling rate, surface properties, and cell viability, growth and proliferation. Among different scaffolding materials, a wide range of natural biological macromolecules and synthetic macromolecules have been utilized to produce scaffolds with multifunctionality for cardiac tissue engineering (CTE). In this review, we have focused on recent achievements in the field of synthetic biodegradable macromolecules (such as aliphatic polyesters, polyurethane, poly (glycerol sebacate)) and the significant strategies to construct electrically conductive scaffolds to regenerate the function of native cardiac tissue. These biodegradable macromolecules have several attractive properties, including biocompatibility, elasticity, good mechanical properties, compatibility with native cardiac tissue, and proper surface biochemistry to increase cardiac cell adhesion, making them appropriate candidates for CTE. Recently, a growing trend in the use of conductive scaffolds for cardiac regeneration has been witnessed. Different materials ranging from metals, ceramics, and polymers have been used as parts of conductive scaffolds for CTE, possessing conductivity assortments from a range of semiconductive to conductive. Moreover, this review paper also focuses on the main strategies to create electroconductive scaffolds for in vitro cardiac muscle regeneration.

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Myocardial tissue engineering: Fundamentals and future

Cited by 2 publications

References 62 publications

To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease

To Repair a Broken Heart: Stem Cells in Ischemic Heart Disease

Biodegradable functional macromolecules as promising scaffolds for cardiac tissue engineering

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