Myocarditis and disseminated intravascular coagulation in scrub typhus

Pericarditis due to Tsutsugamushi Disease

“…The clinical clues of Tsutsugamushi Disease are high fever, rash and eschar formation. The clinical manifestation develops from generalized vasculitis and disseminated intravascular coagulation (3). The pathologic changes are endothelial oedema, perivasculitis and lymphocytic and monocytic infiltration (4).…”

“…Rickettsia tsutsugamushi may cause systemic vasculitis and perivasculitis, which are caused by the proliferation of R. tsutsugamushi in endothelial cells of the microvascular system (2). Such microangiopathies frequently involve the heart, lungs, brain and kidneys (3,4). It also presents as serositis, including pericarditis (1).…”

A Scanning and Transmission Electron Microscopic Examination of Rickettsia Tsutsugamushi-Infected Human Endothelial, MRC-5, and L-929 Cells

“…Scrub typhus is a disorder caused by the infection of the endothelium of small veins, arteries, and capillaries with Rickettsia tsutsugamushi (1 ,2). The consequence of infection is a focal vasculitis and perivasculitis of these vessels and involves numerous organs and the coagulation mechanism (2)(3)(4)(5) . The important role that the human endothelial (HE) cell plays in the pathogenesis of scrub typhus , and the fact that HE cells maintain their differentiated structural and functional characteristics when cultured in vitro (6)(7)(8), prompted us to investigate the ultrastructural events resulting from the infection of these cells with the Karp strain of R , tsutsugamushi.…”

Queensland tick typhus: three cases with unusual clinical features

“…Myocarditis has been described in several rickettsial infections, including those caused by R. rickettsii , R. helvetica , R. africae , R. japonica and R. conorii. Of the rickettsial diseases occurring in Australia, numerous cases of myocarditis related to scrub typhus have beenreported . There is a single case report of fatal murine typhus ( R. typhi ) where myocarditis was found on autopsy .…”

“…13 Of the rickettsial diseases occurring in Australia, numerous cases of myocarditis related to scrub typhus have been reported. [14][15][16][17][18] There is a single case report of fatal murine typhus (R. typhi) where myocarditis was found on autopsy. 19 Queensland tick typhus (QTT) caused by R. australis is generally a mild infection, although there are a few reports of severe illness 20,21 and one fatal case.…”