Myocarditis associated with COVID-19 and its vaccines - a systematic review

Rout, Amit; Suri, Sarabjeet Singh; Vorla, Mounica; Kalra, Dinesh

doi:10.1016/j.pcad.2022.10.004

Cited by 17 publications

(10 citation statements)

References 110 publications

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“…As might be expected knowing manifestations of the disease itself, 49 the rates of both complications in the CME-ME/COVID-19 data set were higher than in the comparable data sets in this study. Admittedly, the numbers collected in this study are insufficient to prove causality over coincidence; this conclusion would require much larger data sets 14–23 . The assessment of risk is complicated by age and burden of preexisting natural disease.…”

Section: Discussionmentioning

confidence: 90%

“…Although vaccine safety is addressed by data collected in this study, the data are insufficient to address vaccine efficacy. Both concerns are topics of other studies 13–23 . Another limitation to this study became apparent during analysis of the vast amount of data collected.…”

Section: Discussionmentioning

confidence: 98%

“…Admittedly, the numbers collected in this study are insufficient to prove causality over coincidence; this conclusion would require much larger data sets. [14][15][16][17][18][19][20][21][22][23] The assessment of risk is complicated by age and burden of preexisting natural disease. Approximately half of the deaths in the vaccine surveillance groups were in ages beyond life expectancy.…”

Section: Contributions Of the Medical Examiner To Epidemic Surveillancementioning

confidence: 99%

“…Addressing the accuracy of death certification is a limitation beyond the range of this study. Somewhere between 84% and 87% of COVID-19-related deaths [13][14][15][16][17][18][19][20][21][22][23] Another limitation to this study became apparent during analysis of the vast amount of data collected. Not having a tracking database developed before the onset of the pandemic presented a challenge in designing a novel, complex data collection tool concurrent with data entry.…”

Section: Limitations Of Studymentioning

confidence: 99%

“…Within 3 months of the disease outbreak, KCMEO was fully engaged in a COVID-19 surveillance project with a dedicated surveillance team and data collection instrument to assist public health efforts in monitoring the spread and mortality of COVID-19 in King County. Later, with the advent of COVID-19 vaccines, KCMEO addressed concerns about the efficacy and safety of vaccines 13–23 by expanding surveillance to include deaths occurring within 28 months of known vaccination. This report examines the experience, from January 2020 through July 2022, of KCMEO's surveillance efforts, analysis of the data collected, and the value of the medical examiner (ME) in epidemic surveillance.…”

mentioning

confidence: 99%

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Medical Examiner Surveillance of the COVID-19 Pandemic in King County, Washington, USA

Harruff

Silva

Lubin

2023

Am J Forensic Med Pathol

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The King County Medical Examiner's Office in Seattle, Wash, initiated a surveillance project with a dedicated team and database tracking the spread of severe acute respiratory syndrome coronavirus 2, deaths due to coronavirus disease 2019 (COVID-19), and deaths occurring within 28 days of COVID-19 vaccination. From January 2020 through July 2022, the results of 13,801 nasal/nasopharyngeal swabs from 7606 decedents tested for the virus were assembled in the surveillance database. Generally, 2 samples were collected and tested separately by 2 different laboratories. Positive rates increased from 5.7% in 2020 to 14.3% in 2022. Of 744 decedents positive for the virus, autopsies were performed on 418 (56%); of these, 106 (25%) died of COVID-19 as either the primary or a contributing cause. Comparison of autopsy findings of those dying of COVID-19 with those positive for the virus but dying of other causes demonstrated increased risk for those with preexisting conditions. Of 1035 deaths reported within 28 days of vaccination, the rates of thrombotic complications and myocarditis were no higher than in other decedents. This study provides evidence of the value to public health surveillance of an adequately resourced medical examiner office in tracking viral spread in the community, understanding disease mortality, and assessing vaccine safety.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 98%