Myocarditis by mesalazine with cardiac magnetic resonance imaging

García-Ferrer, Luis; Estornell, Jordi; Palanca, Víctor

doi:10.1093/eurheartj/ehn615

Cited by 23 publications

(11 citation statements)

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“…Corticosteroids could be considered to expedite resolution of pericarditis or myocarditis . Re‐challenge with 5‐aminosalicylic acid puts patient at high risk for recurrence of inflammation …”

Section: Resultsmentioning

confidence: 99%

Systematic review: safety of mesalazine in ulcerative colitis

Sehgal

Colombel

Aboubakr

et al. 2018

Aliment Pharmacol Ther

121

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Patients on mesalazine should be monitored for worsening of ulcerative colitis and development of new onset organ dysfunction. High-dose mesalazine appears to have similar safety profile as low dose, and is not associated with greater risk of adverse events. Prior to placing a patient on mesalazine, baseline liver and renal function should be evaluated. Renal function should be periodically assessed, whereas other testing should be performed depending on development of symptoms.

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Section: Resultsmentioning

confidence: 99%

Systematic review: safety of mesalazine in ulcerative colitis

Sehgal

Colombel

Aboubakr

et al. 2018

Aliment Pharmacol Ther

121

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“…Hash shading represents affected area. (A) Patchy, mid-myocardial enhancement in posterior wall and inferior interventricular septum (present case); (B) Subepicardial enhancement in anterior wall and transmural extension in interventricular septum; also in the interatrial septum (not shown);3 (C) Subepicardial enhancement in apical inferior wall and transmural enhancement in interventricular septum;4 (D) Subepicardial enhancement in inferior and lateral walls 2…”

Section: Discussionmentioning

confidence: 75%

Cardiac MRI-confirmed mesalamine-induced myocarditis

et al. 2015

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A 38-year-old Caucasian man with a medical history significant for inflammatory bowel disease (IBD) and mesalamine use presented to the emergency department with stabbing, pleuritic, substernal chest pain over the previous 2 days. Findings of leucocytosis, elevated cardiac enzymes and inflammatory markers, T-wave or ST-segment abnormalities and left ventricular systolic dysfunction suggested mesalamine-induced myocarditis. However, a cardiac MRI confirmed the diagnosis. Signs and symptoms improved within days of withdrawal of mesalamine, and initiation of corticosteroids and follow-up studies within the next year were unremarkable. Importantly, the diagnosis of mesalamine-induced myocarditis confirmed via cardiac MRI is a step rarely performed in published cases.

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“…Pericarditis and myocarditis have been reported as extra intestinal CD manifestations [1]. Cardiomyopathies have also been reported and related to adverse effects of mesalazine, sulfasalazine and TNF-α antibodies [2,3]. Furthermore, selenium deficiency has been implicated in pathogenesis of LV dysfunction in the setting of CD [4].…”

Section: Discussionmentioning

confidence: 99%

Crohn's Disease and Nontropical Endomyocardial Fibrosis

Ennezat

Noël²,

Tillie‐Leblond³

et al. 2013

Cardiology

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The pathogenesis of endomyocardial fibrosis (EMF) is poorly understood. EMF may result from autoimmune scarring of the endocardium. Clinically, EMF presents as a restrictive cardiomyopathy. EMF is commonly reported in tropical countries. In Western countries, EMF is associated with hypereosinophilia and reported as Loeffler endocarditis. We report a Caucasian patient with Crohn's disease and EMF, and discuss a possible linkage between the two conditions.

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Myocarditis by mesalazine with cardiac magnetic resonance imaging

Cited by 23 publications

References 0 publications

Systematic review: safety of mesalazine in ulcerative colitis

Systematic review: safety of mesalazine in ulcerative colitis

Cardiac MRI-confirmed mesalamine-induced myocarditis

Crohn's Disease and Nontropical Endomyocardial Fibrosis

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