Myoclonic epilepsy in Down syndrome and Alzheimer disease

Aller-Alvarez, J.S.; Menéndez-González, Manuel; Ribacoba-Montero, R.; Salvadó, María; Vega, Verónica Olmedo; Suárez-Moro, R.; Sueiras, M.; Toledo, Manuel; Salas-Puig, Javier; Álvarez-Sabín, José

doi:10.1016/j.nrleng.2014.12.019

Cited by 16 publications

(31 citation statements)

References 16 publications

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“…It is possible that the true incidence of epilepsy among patients with AD is even higher than we have reported. Several studies looking at the semiology of seizures in dementia, and AD in particular have recognized that seizures in this population are more likely to be focal in onset, often non-motor and rarely generalized tonic-clonic (18, 48, 49). Such subtle seizures are easily missed.…”

Section: Resultsmentioning

confidence: 99%

A Longitudinal Study of Epileptic Seizures in Alzheimer's Disease

et al. 2019

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The prevalence of epileptic seizures is increased in patients in the clinical stages of Alzheimer's disease (AD) when compared to age-matched cognitively normal populations. In previously reported work from the Presentation of Epileptic Seizures in Dementia (PrESIDe) study, we identified a clinical suspicion of epilepsy in between 12.75 and 28.43% of patients with AD recruited from a memory clinic. EEGs were not performed in this study. Patients with epilepsy performed similarly to patients without epilepsy on cognitive testing at the time of recruitment but were more impaired on two measures of everyday functioning [Cambridge Behavioral Inventory—Revised and Clinical Dementia Rating (CBI-R and CDR)]. On repeated testing in this 12-month follow-up study, patients in whom a suspicion of epilepsy was identified performed significantly worse on cognitive function testing (p = 0.028) in addition to maintaining a difference on the informant questionnaires (CBI-R p < 0.001, CDR p = 0.020). These findings suggest that seizures in this population could be a marker of a more rapid decline and worse prognosis.

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Section: Resultsmentioning

confidence: 99%

A Longitudinal Study of Epileptic Seizures in Alzheimer's Disease

et al. 2019

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“…Elderly patients with DS particularly with Alzheimer Diseases have an increased susceptibility to develop late‐onset myoclonic epilepsy (LOMEDS). The association of generalised epilepsy with elderly DS represents an epiphenomenon in evolution which is associated with a progressive deterioration of cognitive and motor functions …”

Section: Cardiac Involvementmentioning

confidence: 99%

Multiorgan involvement and management in children with Down syndrome

et al. 2020

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“…In DS patients over 50 years of age, late myoclonic seizures have been observed, especially in cases with dementia [24]. Moreover, epileptic seizures exacerbate the impairment of cognitive functions [25]. This type of seizures can be successfully treated with new AEDs, such as LVT and TPM; VPA was, also, used with good effect [1,25].…”

Section: Down Syndromementioning

confidence: 99%

“…Moreover, epileptic seizures exacerbate the impairment of cognitive functions [25]. This type of seizures can be successfully treated with new AEDs, such as LVT and TPM; VPA was, also, used with good effect [1,25]. However, the risk of side effects in these patients is higher, including those with impact on central nervous system: somnolence, dizziness, distractibility [26].…”

Section: Down Syndromementioning

confidence: 99%

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Treatment of Epilepsy Associated with Common Chromosomal Developmental Diseases

et al. 2020

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AbstractChromosomal diseases are heterogeneous conditions with complex phenotypes, which include also epileptic seizures. Each chromosomal syndrome has a range of specific characteristics regarding the type of seizures, EEG findings and specific response to antiepileptic drugs, significant in the context of the respective genetic etiology. Therefore, it is very important to know these particularities, in order to avoid an exacerbation of seizures or some side effects. In this paper we will present a review of the epileptic seizures and antiepileptic treatment in some of the most common chromosomal syndromes.

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Myoclonic epilepsy in Down syndrome and Alzheimer disease

Cited by 16 publications

References 16 publications

A Longitudinal Study of Epileptic Seizures in Alzheimer's Disease

A Longitudinal Study of Epileptic Seizures in Alzheimer's Disease

Multiorgan involvement and management in children with Down syndrome

Treatment of Epilepsy Associated with Common Chromosomal Developmental Diseases

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