Myoclonus Associated With Disulfiram

Kongasseri, Sreejayan; Praharaj, Samir Kumar

doi:10.1176/appi.neuropsych.12030073

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…AMT was discontinued without any group of patients; in those that did, an abnormal/normal electroencephalogram was reported. 58,62 Consequently, AMT-induced MCL may have a cortical and subcortical source. 66 MCL can be classified into multifocal, palatal and cranial types.…”

Section: Discussionmentioning

confidence: 99%

The Link Between Amitriptyline and Movement Disorders: Clinical Profile and Outcome

Rissardo

Caprara

2020

Ann Acad Med Singap

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Introduction: Amitriptyline (AMT) is a tricyclic antidepressant. In this review, we evaluate the clinical and epidemiological profile, pathological mechanisms and management of AMT-associated movement disorders. Materials and Methods: A search for relevant reports in 6 databases was performed. Studies that reported patients developed only ataxia or tremor after AMT use were excluded. Results: A total of 48 reports on 200 cases were found. AMT-associated movement disorders included myoclonus (n = 26), dyskinesia (n = 11), dystonia (n = 8), stutter (n = 5), akathisia (n = 3) and restless legs syndrome (n = 1). For less well-defined cases, 99 patients had dyskinesia, 19 had psychomotor disturbances, 3 had myoclonus, 11 had dystonia, 12 had Parkinsonism and 1 each had akathisia and extrapyramidal symptoms. Mean and standard deviation (SD) and median ages were 45.40 years (SD 16.78) and 40 years (range 3.7–82 years), respectively. Over half were women (58.13%) and the most common indication was depression. Mean and median AMT doses were 126 mg (SD 128.76) and 75 mg (range 15–800 mg), respectively. In 68% of patients, onset of movement disorders was <1 month; time from AMT withdrawal to complete recovery was <1 month in 70% of cases. A weak negative linear correlation (r = −0.0904) was found between onset of movement disorders and AMT dose. AMT withdrawal was the most common treatment. Conclusion: Amitriptyline is associated with various movement disorders, particularly myoclonus, dystonia and dyskinesias. Stutters and restless legs syndrome are some of the less common associations. Ann Acad Med Singapore 2020;49:236–51 Key words: Akathisia, Drug-induced, Dyskinesia, Dystonia, Myoclonus

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Section: Discussionmentioning

confidence: 99%

The Link Between Amitriptyline and Movement Disorders: Clinical Profile and Outcome

Rissardo

Caprara

2020

Ann Acad Med Singap

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“…Other types reported in the extant literature include myoclonus, drop attacks, and olfactory forebrain seizures. 6,8,13,14 EEG findings are reported to be abnormal in most of the reported cases except two. EEG was not performed in the current patient.…”

Section: Dose and Duration Of Onset Of The Seizurementioning

confidence: 81%

“…Other types reported in the extant literature include myoclonus, drop attacks, and olfactory forebrain seizures. 6,8,13,14…”

mentioning

confidence: 99%

Disulfiram-Associated Generalized Tonic–Clonic Seizures

Vaidyanathan,

Raghunathan,

Udupa

et al. 2023

American Journal of Therapeutics

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“…There are very few case reports regarding DSF-induced seizures. [ 2 3 ] This shows the need for research, especially in the Indian context, when alcohol consuming population and the wide use of DSF (sometimes surreptitiously) in de-addiction centers are considered. However, because of the ADRs and the dangerous effects of DSF with alcohol, it has to be prescribed with caution and always monitored by medical supervision.…”

mentioning

confidence: 99%