Myoclonus status revealing COVID 19 infection

Dina, Ben Mohamed; Zouari, R.; Jihen, Ketata; Nabli, Fatma; Blel, S.; Samia, Ben Sassi

doi:10.1016/j.seizure.2022.11.010

Cited by 7 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the neurological manifestations were consistent across all pandemic waves, the frequency of these manifestations varied based on the wave of the pandemic and the age of the patient. The neurological manifestations described in this study have been documented in scientific literature, including rare cases [ 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Discussionmentioning

confidence: 88%

Neurological Manifestations of Acute SARS-CoV-2 Infection in Pediatric Patients: A 3-Year Study on Differences between Pandemic Waves

Vivisenco,

Lescaie,

Dragomirescu

et al. 2024

Viruses

View full text Add to dashboard Cite

This study analyzed the neurological manifestation profiles of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection across pandemic waves in pediatric patients. The study collected data on patients aged between 0 and 18 years, diagnosed with acute SARS-CoV-2 infection, admitted to a pediatric tertiary hospital between 1 March 2020 and 28 February 2023. This study included 1677 patients. Neurological manifestations were noted in 10% (n = 168) of patients with a median age of 3.2 years (interquartile range: 1–11.92). Neurological manifestations were significantly associated with the pandemic waves (p = 0.006) and age groups (p < 0.001). Seizures were noted in 4.2% of cases and reached an increasing frequency over time (p = 0.001), but were not associated with age groups. Febrile seizures accounted for the majority of seizures. Headache was reported in 2.6% of cases and had similar frequencies across the pandemic waves and age groups. Muscular involvement was noted in 2% of cases, reached a decreasing frequency over time (p < 0.001), and showed different frequencies among the age groups. Neurological manifestations of acute SARS-CoV-2 infection exhibit distinct patterns, depending on the pandemic wave and patient age group. The Wuhan and Omicron waves involved the nervous system more often than the other waves.

show abstract

Section: Discussionmentioning

confidence: 88%

Neurological Manifestations of Acute SARS-CoV-2 Infection in Pediatric Patients: A 3-Year Study on Differences between Pandemic Waves

Vivisenco,

Lescaie,

Dragomirescu

et al. 2024

Viruses

View full text Add to dashboard Cite

show abstract

“…The production of recombinant monoclonal antibodies from the CSF (plasmablasts) of such patients and pathogenicity assessment in animal models could provide more solid information regarding their functionality. Thirty-one cases of myoclonus and ataxia associated with COVID-19 were reported in a recent review article [ 5 ], and eleven more cases were reported in five case reports and case series afterwards [ 23 , 24 , 25 , 26 , 27 , 28 ]. In one of these cases, anti-GFAP-antibodies were identified [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Anti-Neuronal Autoantibodies in COVID-19-Associated Limbic Encephalitis with Acute Cerebellar Ataxia and Myoclonus Syndrome: Case Report and Literature Review

et al. 2023

View full text Add to dashboard Cite

Since the outbreak of coronavirus (COVID-19) in 2019, various rare movement disorders and cognitive changes have been recognized as potential neurological complications. The early treatment of some of these allows rapid recovery; therefore, we must diagnose these manifestations in a timely way. We describe the case of a 76-year-old man infected with severe acute respiratory syndrome coronavirus-2 who presented with confusion and hallucinations and was admitted to our hospital 14 days after the onset of symptoms. One day later, he developed generalized myoclonus, dysarthria and ataxia, and tonic clonic seizures and was admitted to the intensive care unit. A diagnosis of COVID-19-associated autoimmune encephalitis with characteristics of limbic encephalitis and immune-mediated acute cerebellar ataxia and myoclonus syndrome was supported by alterations in the limbic system shown in magnetic resonance imaging, lateralized discharges shown in electroencephalography, a slightly elevated protein level in the cerebrospinal fluid (CSF), and indirect immunofluorescence in the CSF with autoantibody binding to anatomical structures of the cerebellum and hippocampus. The patient improved with 2 weeks of corticosteroid treatment and four sessions of plasmapheresis. Our current case study describes a rare case of COVID-19-related limbic encephalitis with immune-mediated acute cerebellar ataxia and myoclonus syndrome (ACAM syndrome) and strengthens the need for tissue-based assays (TBAs) to screen the serum and/or CSF of patients highly suspected to have autoimmune encephalitis. We believe that the timely diagnosis and targeted aggressive immunotherapy were mainly responsible for the patient’s total recovery.

show abstract

“…There are, however, frequent reports of encephalitis ensuing acute infection, including presumed autoimmune encephalitis, but cases in which autoantibodies in CSF have been screened for and identified are few [5–8]. In addition, cases with myoclonia associated with COVID‐19 have been described [9–14].…”

Section: Introductionmentioning

confidence: 99%

Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid

Lindqvist

Cunningham

Mulder

et al. 2023

Euro J of Neurology

View full text Add to dashboard Cite

Background and purposeCOVID‐19 is associated with multiple neurological manifestations. The clinical presentation, trajectory, and treatment response for three cases of myoclonus during COVID‐19 infection, with no previous neurological disease, are decsribed.MetodsAnalysis of cerebrospinal fluid from the cases using indirect immunohistochemistry.ResultsAntibodies against rodent brain tissue, and similarities in staining patterns were observed, indicating the presence of antineuronal immunoglobulin G autoantibodies targeting astrocytes in the hippocampus.ConclusionOur results demontrate cerebrospinal fluid antineuronal antibodies indicating an an autoimmune involvment in the pathogenesis in COVID‐19 associated myoclonus.

show abstract

Myoclonus status revealing COVID 19 infection

Cited by 7 publications

References 6 publications

Neurological Manifestations of Acute SARS-CoV-2 Infection in Pediatric Patients: A 3-Year Study on Differences between Pandemic Waves

Neurological Manifestations of Acute SARS-CoV-2 Infection in Pediatric Patients: A 3-Year Study on Differences between Pandemic Waves

Cerebrospinal Fluid Anti-Neuronal Autoantibodies in COVID-19-Associated Limbic Encephalitis with Acute Cerebellar Ataxia and Myoclonus Syndrome: Case Report and Literature Review

Myoclonus in patients with COVID‐19: Findings of autoantibodies against brain structures in cerebrospinal fluid

Contact Info

Product

Resources

About