Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia

Ishii, Kazuyoshi; Nakaya, Aya; Fujita, Shinya; Satake, Atsushi; Azuma, Yukio; Tsubokura, Yukie; Saito, Ryo; Konishi, Akiko; Hotta, Masatoshi; Yoshimura, Hideyuki; Ito, Tomoki; Nomura, Shosaku

doi:10.1016/j.lrr.2019.03.001

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Thus, CML leukaemic cells may predominate in the CNS while BM remains uninvolved . 18 The involvement of extramedullary sites is correlated with a very poor clinical outcome. 8 Oishima et al observed better survival in patients with isolated CNS relapse than in patients with CNS relapse after or simultaneously with systemic relapse.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid infiltration by chronic myeloid leukaemia: Evaluation of cytomorphological features

et al. 2022

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Background and Aim To describe the cytomorphological findings of all cerebrospinal fluid (CSF) cytology samples showing infiltration by chronic myeloid leukaemia (CML) and their correlation with haematological findings. Materials and Methods A retrospective analysis of all CSF samples reported as showing infiltration by CML on cytology from January 2014 to December 2021 was performed. Results A total of 10 cases with positive CSF cytology were evaluated. The mean age of the patients was 34.1 years (range 17‐70 years). There were more males than females. All cases were pre‐diagnosed cases of CML on haematological investigations. On cytology, the smears showed atypical/immature blast‐like cells, with a high nucleo‐cytoplasmic ratio, opened‐up chromatin, 1‐2 conspicuous nucleoli and a scant to moderate amount of agranular to fine granular cytoplasm along with occasional granulocytic precursors. The shortest time interval for CSF positivity in a known case of CML was 5 months, and the longest interval was 11 years. Conclusion It is extremely uncommon to encounter CML infiltration in CSF. Timely analysis of CSF cytology samples can allow quick diagnosis and alter the patient management protocol.

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Section: Discussionmentioning

confidence: 99%

Cerebrospinal fluid infiltration by chronic myeloid leukaemia: Evaluation of cytomorphological features

et al. 2022

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“…Tyrosine kinase inhibitors (TKIs) have dramatically improved the prognosis and survival of patients with chronic myeloid leukemia (CML) and have decreased the chances of progression to blast crisis (BC). [1] Extramedullary BC (EBC) can occur as an isolated event in 5%-10% of patients; however, the central nervous system (CNS) as a site of EBC is extremely rare. [2,3] With Imatinib, the majority of patients are expected to achieve a complete cytogenetic response.…”

Section: Introductionmentioning

confidence: 99%

Isolated central nervous system blast crisis in chronic myeloid leukemia - Report of two cases

Arumugam

Bommannan

Kalaiyarasi

et al. 2020

Indian Journal of Medical and Paediatric Oncology

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Extramedullary blast crisis (BC) presenting as the central nervous system (CNS) involvement in chronic myeloid leukemia (CML) is rare and usually accompanies systemic involvement. Imatinib has shown efficacy in treating patients with CML in accelerated or blastic phases. However, CNS penetration of Imatinib is poor due to the P-glycoprotein mediated efflux mechanisms. Therefore, patients on long-term Imatinib therapy with hematological and cytogenetic remission may rarely present with CNS BC. Isolated CNS BC is uncommon and the literature is limited to only a few case reports. Here, we present two cases of isolated CNS BC in patients with BCR ABL positive CML on treatment.

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Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia

Abstract: HighlightsPatient with chronic myeloid leukemia in the chronic phase developed myodesopsia.Patient was in molecular response in bone marrow.It was an isolated central nervous system blast crisis.

Cited by 2 publications

References 7 publications

Cerebrospinal fluid infiltration by chronic myeloid leukaemia: Evaluation of cytomorphological features

Cerebrospinal fluid infiltration by chronic myeloid leukaemia: Evaluation of cytomorphological features

Isolated central nervous system blast crisis in chronic myeloid leukemia - Report of two cases

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