Myoelectrical Activity and Muscle Morphology in a Rat Model of Myofascial Trigger Points Induced by Blunt Trauma to the Vastus Medialis

Huang, Qiang-Min; Ye, Gang; Zhao, Zhen-Yan; Lv, Jiao-Jiao; Tang, Longlong

doi:10.1136/acupmed-2012-010129

Cited by 48 publications

(76 citation statements)

References 19 publications

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“…However, pain often relapses after treatment targeting MTrPs, and it is difficult to treat completely (Graboski et al, 2005; Cummings and Baldry, 2007; Park et al, 2012). Substantial effort has been dedicated to understanding the pathophysiology of MTrPs, and different theories have been proposed, including the integrated hypothesis (Vázquez-Delgado et al, 2009; Bron and Dommertholt, 2012), the central sensitization theory (Mense, 1994; Xu et al, 2010), and the myoelectrical theory (Ge et al, 2006; Huang et al, 2013). However, whether MTrPs are a peripheral or central phenomenon remains controversial (Fernández-de-las-Peñas and Dommerholt, 2014).…”

Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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Myofascial pain, presented as myofascial trigger points (MTrPs)-related pain, is a common, chronic disease involving skeletal muscle, but its underlying mechanisms have been poorly understood. Previous studies have revealed that chronic pain can induce microstructural abnormalities in the cerebral gray matter. However, it remains unclear whether the brain gray matters of patients with chronic MTrPs-related pain undergo alteration. In this study, we employed the Diffusion Kurtosis Imaging (DKI) technique, which is particularly sensitive to brain microstructural perturbation, to monitor the MTrPs-related microstructural alterations in brain gray matter of patients with chronic pain. Our results revealed that, in comparison with the healthy controls, patients with chronic myofascial pain exhibited microstructural abnormalities in the cerebral gray matter and these lesions were mainly distributed in the limbic system and the brain areas involved in the pain matrix. In addition, we showed that microstructural abnormalities in the right anterior cingulate cortex (ACC) and medial prefrontal cortex (mPFC) had a significant negative correlation with the course of disease and pain intensity. The results of this study demonstrated for the first time that there are microstructural abnormalities in the brain gray matter of patients with MTrPs-related chronic pain. Our findings may provide new insights into the future development of appropriate therapeutic strategies to this disease.

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Section: Introductionmentioning

confidence: 99%

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

et al. 2016

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“…This hypothesis requires further research. 19 In this study, conclusions about the effectiveness of acupuncture are limited by the absence of a control group, lack of unblinded assessment and combination with self-exercise.…”

Section: Resultsmentioning

confidence: 97%

Wet Needling of Myofascial Trigger Points in Abdominal Muscles for Treatment of Primary Dysmenorrhoea

Huang

Liu

2014

Acupunct Med

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“…The 36 rat models were anesthetized with injections of 4 mL/kg 10% chloral hydrate into the abdominal cavity and then fixed on a board with a homemade striking device [6]. The site of the left GM was marked.…”

Section: Methodsmentioning

confidence: 99%

“…Histological and electrophysiological studies of myofascial trigger spots (MTrSs), which are similar to human MTrPs in many aspects [3, 4], have revealed pathological changes with abnormal contracture knots in muscle fibers and electromyographic (EMG) features of spontaneous electrical activity (SEA) [1, 5, 6]. Abnormal contracture knots may be initiated by a synaptic dysfunction at the motor endplate with the excessive acetylcholine (ACh) [7] release and changes in ACh receptor (AChR) [8] or acetylcholinesterase (AChE) [9] activities.…”

Section: Introductionmentioning

confidence: 99%

Decreased Spontaneous Electrical Activity and Acetylcholine at Myofascial Trigger Spots after Dry Needling Treatment: A Pilot Study

Liu

Huang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Objective The aims of this study are to investigate the changes in spontaneous electrical activities (SEAs) and in acetylcholine (ACh), acetylcholine receptor (AChR), and acetylcholine esterase (AChE) levels after dry needling at myofascial trigger spots in model rats. Materials and Methods Forty-eight male Sprague-Dawley rats were divided into four groups. Thirty-six rats were assigned to three model groups, which underwent MTrSs modeling intervention. Twelve rats were assigned to the blank control (BC) group. After model construction, the 36 model rats were randomly subdivided into three groups according to treatment: MTrSs model control (MC) and two dry needling groups. One dry needling group received puncturing at MTrSs (DN-M), whereas the other underwent puncturing at non-MTrSs (DN-nM). Dry needling treatment will last for two weeks, once a week. SEAs and ACh, AChR, and AChE levels were measured after one-week rest of dry needling treatment. Results The amplitudes and frequencies of endplate noise (EPN) and endplate spike (EPS) significantly decreased after dry needling treatment in the DN-M group. Moreover, ACh and AChR levels significantly decreased, whereas AChE significantly increased after dry needling treatment in the DN-M group. Conclusion Dry needling at the exact MTrSs is more effective than dry needling at non-MTrSs.

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Myoelectrical Activity and Muscle Morphology in a Rat Model of Myofascial Trigger Points Induced by Blunt Trauma to the Vastus Medialis

Cited by 48 publications

References 19 publications

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

Microstructural Abnormalities Were Found in Brain Gray Matter from Patients with Chronic Myofascial Pain

Wet Needling of Myofascial Trigger Points in Abdominal Muscles for Treatment of Primary Dysmenorrhoea

Decreased Spontaneous Electrical Activity and Acetylcholine at Myofascial Trigger Spots after Dry Needling Treatment: A Pilot Study

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