Myoepithelial and epithelial–myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012

Tan, Puay Hoon; Ellis, Ian O.

doi:10.1136/jclinpath-2012-201078

Cited by 120 publications

(72 citation statements)

References 68 publications

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“…Although there is no standard classification scheme for MBC, they are categorized mainly into five subtypes including squamous cell carcinoma of ductal origin, spindle cell carcinoma, matrix-producing carcinoma, carcinosarcoma and metaplastic carcinoma with osteoclastic giant cells (Wargotz et al, 1989a;1989b;1990a;1990b). In the updates of the WHO Classification of breast tumors, malignant myoepithelioma incorporated into MBC (Tan et al, 2013). Transformation of one type of metaplastic carcinoma to another can also be observed (Chuthapisith et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Metaplastic Breast Carcinoma: a Heterogeneous Disease

Gültekin¹,

Eren²,

Babacan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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The aim of this study is to evaluate clinicopathologic characteristics and the multi-disciplinary treatment results of metaplastic breast cancer (MBC) patients treated in a single institute. Seventeen female patients with MBC treated in our department between June 2000 and January 2012 were identified and retrospectively evaluated. The median age at diagnosis was 46 years (range, 26-66 years). The median tumor size at diagnosis was 3.5 cm (range 1.5-12 cm). Six (35%) patients underwent breast conservation surgery and 11 (65%) mastectomy. Axillary lymph node metastasis was found in 6 (35%) patients. Twelve (71%) had triple negative tumors. Postoperative RT and systemic adjuvant treatment was given to all patients accordingly to stage and biological characteristics. Median follow-up time was 27 months (range, 12-151 months). At the time of this analysis, 14 (82%) patients were alive with no evidence of disease, and 1 (6%) was alive with disease. The 3-year OS was 91% and 5-year 80%, and DFS rates were 76% and 76%, respectively. Despite the young age of our patients with mostly high grade tumors, larger tumor size and higher rates of lymph node metastasis, the survival outcomes in our study are favorable in comparison with previously reported series.

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Section: Introductionmentioning

confidence: 99%

Metaplastic Breast Carcinoma: a Heterogeneous Disease

Gültekin¹,

Eren²,

Babacan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Use of preoperative core needle biopsy has a sensitivity of 75% in separating PT from fibroadenoma, therefore, any solid mass that was previously deemed benign but subsequently showing rapid growth would necessitate excisional biopsy. 12,13 Surgery is the mainstay of treatment in Phyllodes tumor for local disease. Current guidelines by National Comprehensive Cancer Network, malignant phyllodes are to be treated like sarcoma, rather than typical carcinoma breast.…”

Section: Discussionmentioning

confidence: 99%

Phyllodes tumor of right breast with metastasis to lungs, rare presentation

Nichkaode

Patel

2017

Int Surg J

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Incidence of Phylloids tumor of the breast is between 0.5% to 2% of all breast tumors. Most common age of occurrence is between 45-49 years but it can occur even at younger age. It is important to distinguish it from more benign tumors of the breast like fibroadenoma as far the management is concerned. Phylloids are fibroepethilial tumors with malignant potential, so needs complete excision. We present a case of 53 years female who underwent simple mastectomy for high grade Phylloids tumor in her right breast a year back, presented with breathlessness and local recurrence, proved to be metastatic Phylloids to lung causing left pleural effusion and nodule in the right upper lobe of lung. When the effusion was tapped it appeared to be pleomorphic spindle cell metastasis.

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“…In benign cases with histological ambiguity, the WHO Working Group recommends favouring a diagnosis of fibroadenoma or using the descriptive term "benign fibroepithelial neoplasm". [11] Statistics:…”

Section: Methodsmentioning

confidence: 99%

“…Overall recurrence rate of both are comparable suggesting similar outcome. [11] Fibroadenomas with sclerosing adenosis, papillary apocrine hyperplasia, cysts, or epithelial calcifications have been designated as "complex". [12] Fibroadenomas can occur in women of any age, but the peak incidence is during the second and third decades of life.…”

Section: IVmentioning

confidence: 99%