Myoepithelial carcinoma of buccal mucosa: A rare tumor

Lata, Jeevan; Ahmad, Farooq; Chand, Vimal

doi:10.4103/0976-237x.132372

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…have stated that MC arising from pleomorphic adenomas show a portion of ductal differentiation, whereas this may not be necessary for MC arising de novo . [ 20 ] We did not observe any ductal pattern.…”

Section: Discussionmentioning

confidence: 67%

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

Gupta

Khare

Jain

et al. 2018

J Oral Maxillofac Pathol

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Myoepithelial carcinomas (MCs) are difficult to distinguish from their benign counterpart due to diverse morphology. This neoplasm was introduced by Stromeyer et al. in 1975. They comprise of <2% of all salivary gland carcinomas involving most commonly major salivary glands and are characterized by differentiation of tumor cells into myoepithelial cells. The cells may present as epithelioid, plasmacytoid, spindle, clear, stellate and mixed type predominantly. Literature search revealed very few cases reported as clear cell variant of MC. Here, we report a case of clear cell MC involving buccal vestibule extending up to alveolus. The diagnosis was confirmed, and the patient was surgically treated.

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Section: Discussionmentioning

confidence: 67%

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

Gupta

Khare

Jain

et al. 2018

J Oral Maxillofac Pathol

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“…14 Case reports also have documented MCC appearing in the nasopharynx, larynx, and lungs. 7 Patients typically present with an asymptomatic mass, but symptoms may include tenderness, dysphagia, and hoarseness. In palatal tumors, invasion of the bone can be seen in some instances.…”

Section: Discussionmentioning

confidence: 99%

“…Case reports have documented oral cavity MCC occurring in buccal mucosa, hard palate, alveolar ridge, retromolar trigone, and lips. 7 At the time of publication, all current case reports of primary tongue MCC describe tumors that appear to have originated in the base of tongue. 8,9 Myoepithelial cells constitute an important component of glandular acini and ducts.…”

Section: History and Clinical Characteristics Of MCCmentioning

confidence: 99%

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Nicholas

Hanson

Meiklejohn

2019

Clin Med Insights Oncol

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Background: Myoepithelial cell carcinoma is a rare malignant neoplasm of salivary gland origin that typically presents in the parotid gland and minor salivary glands. It has been described previously in head and neck sites such as buccal mucosa, alveolar ridge, and base of tongue. Methods: A 55-year-old man presented with 30 years of right-sided tongue pain and 10 years of gradually worsening ulceration. Physical examination demonstrated a 2.5 cm ulcerative lesion of the anterior right oral tongue. An initial biopsy was consistent with moderately to poorly differentiated squamous cell carcinoma. Imaging included a positron emission tomography (PET)/computed tomography (CT) scan that demonstrated the right tongue lesion as well as hypermetabolic right level II adenopathy. The patient underwent surgical excision of the right tongue, upper aerodigestive tract endoscopy, and a bilateral supraomohyoid neck dissection. The tongue defect was closed primarily. Results: Final pathology of the surgical specimen demonstrated myoepithelial cell carcinoma. All of the margins were free of tumor and no cervical lymph nodes showed metastasis. Immunohistochemistry demonstrated myoepithelial differentiation. The tumor did not show EWSR1 gene rearrangement on genetic testing, suggesting salivary gland origin. Multidisciplinary tumor board evaluation recommended no adjuvant therapy. The patient recovered well after surgery and nearly a year later is without evidence of recurrent or residual disease. Conclusions: We present the first reported case of myoepithelial cell carcinoma with primary origin in the oral tongue and review the available literature on this unusual tumor. We discuss the clinical, pathological, and immunohistochemical features and treatment of myoepithelial cell carcinoma.

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“…Myoepithelial carcinoma, also known as malignant myoepithelioma, is a rare neoplasm that accounts for less than 2% of salivary gland tumors [1]. It forms a painless, slow-growing mass that most commonly arises from the palate and major salivary glands like the parotid [2, 3], although it can arise from the minor glands of the oral mucosa [4, 5]. In a 2015 study involving 29 patients over 10 years, the most common sites were the parotid gland, submandibular gland, and palate [6].…”

Section: Introductionmentioning

confidence: 99%

Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs

Fang

Kornfield

Clavijo

et al. 2019

Case Reports in Pathology

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Myoepithelial carcinoma is an uncommon tumor of the salivary glands, most commonly the parotid gland. Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. Posttreatment imaging demonstrated bilateral pulmonary nodules and a C2 body lesion concerning for metastasis. Biopsy of the lung lesions revealed a monomorphous population of optically clear cells with hyperchromatic and pleomorphic nuclei which were morphologically similar to the prior resection specimen. There are few reported cases of clear cell myoepithelial carcinoma arising from the hard palate, and there are even fewer reports on metastases to the lungs. Due to the low number of reported cases, prognosis and treatment of this neoplasm is not well defined.

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Myoepithelial carcinoma of buccal mucosa: A rare tumor

Cited by 6 publications

References 20 publications

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

Myoepithelial Cell Carcinoma of the Oral Tongue: Case Report and Review of the Literature

Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs

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