Myoepithelial carcinoma of the nasopharynx: Rare case report with clinicopathologic and immunohistochemical features review of literature

Abstract

The nasopharyngeal mass with spindled, plasmacytoid, epithelioid, and clear cell types, was suggested to raise the suspicion of myoepithelial carcinoma in order to diagnose and treat early. The wide surgical excision followed by optimal adjuvant therapy might offer a mode of treatment with better survival results.

A novel low‐grade nasopharyngeal adenocarcinoma characterized by a GOLGB1‐BRAF fusion gene

“…16 The gamut of salivary-type adenocarcinomas has been reported in the nasopharynx. [4][5][6][7][8][9][10][11] Unsurprisingly, the histopathologic and F I G U R E 1 Representative photomicrographs of low-grade nasopharyngeal adenocarcinoma, with GOLGB1-BRAF fusion gene (Hematoxylin and Eosin). A, Lowpower magnification showing irregularly shaped invasive glands containing micropapillary luminal projections.…”

“…The gamut of salivary‐type adenocarcinomas has been reported in the nasopharynx 4‐11 . Unsurprisingly, the histopathologic and molecular attributes of nasopharyngeal salivary‐type malignancies appears to parallel that of their salivary gland counterparts.…”

“…Adenocarcinoma of the nasopharynx ostensibly includes nasopharyngeal papillary adenocarcinoma and salivary gland tumors. 1,[4][5][6][7][8][9][10][11][12] Herein, we report the case of an adult male who presented with a distinctive nasopharyngeal tumor. Morphologically, it did not correspond to any established subtype of nasopharyngeal adenocarcinoma, and was initially diagnosed as nasopharyngeal adenocarcinoma, not otherwise specified (NOS).…”

“…Unlike NPC, the pathogenesis of this heterogeneous group of malignancies remains poorly characterized. Adenocarcinoma of the nasopharynx ostensibly includes nasopharyngeal papillary adenocarcinoma and salivary gland tumors 1,4‐12 …”

A series Cases study of Carcinomas derived from myoepithelial cells in head and neck regions

“…CMCHNs have been observed in the gingiva, palate and tongue, larynx, parapharynx, nasopharynx, nasal cavity, nasal sinus, lacrimal gland, inferior temporal fossa, etc [17,18]. And literatures reported that approximately 75% of EMC [19,20] originated from the parotid gland, 10% from the submandibular gland, 10-15% from the salivary glands, and the remaining occurred in the palate, maxillary sinus, nasal cavity, trachea, and the root of the tongue.…”