Myoepithelial carcinoma or epithelioid sarcoma – A rare diagnosis with poor prognosis. A case report and review of literature

Khazeni, Kristina; LaBove, Hannah; Wilky, Breelyn A.; Rosenberg, Andrew E.; Paulus, Elizabeth; Chim, Harvey; Pearson, J. Matt; Yakoub, Danny

doi:10.1016/j.ijscr.2018.06.016

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…The most recent case was reported by Khazeni et al and discussed a 33-year-old female that presented with pelvic pain ( Khazeni et al, 2018 ). A CT scan of the abdomen and pelvis reveled a 3.6 × 3.1 cm right inguinal mass and the patient underwent an excision and biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…The most common location for myoepithelial carcinoma is the salivary glands, namely the parotid gland, but tumors have also been found in the skin, breast, lung and other soft tissues ( Frost et al, 2014 ). To our knowledge, only seven cases of primary myoepithelial carcinoma of the vulva have been reported ( Miyata et al, 2011 , Fukunaga, 2003 , Hinze et al, 1999 , Khazeni et al, 2018 , Meenakshi and McCluggage, 2009 , Noronha et al, 2006 ). These tumors often present with lobulated, firm, yellow/white or tan masses that are most often painless ( Hornick and Fletcher, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

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Primary myoepithelial carcinoma of the Vulva: Case of a rare tumor with malignant potential and review of literature

Castelow¹,

Carter²,

DePasquale³

2022

Gynecologic Oncology Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Primary myoepithelial carcinoma of the Vulva: Case of a rare tumor with malignant potential and review of literature

Castelow¹,

Carter²,

DePasquale³

2022

Gynecologic Oncology Reports

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“…On the genetic level myoepithelial carcinoma is characterized by various abnormalities related to the predominant cell subtype with an EWSR-PBX1 fusion known for the clear cell variant and the EWSR-ZNF444 translocation known for the epithelioid cell variant [12]. In the rhabdoid variant of myoepithelial carcinoma of the soft tissue of the neck for example, FISH analysis revealed an EWSR Translocation without any other genetic fusions characteristic of EWSR, including EWSR1-NR4A3, TAF15-NR4A3, EWSR1-FLI1, EWSR1-ERG, EWSR1-WT1, EWSR1-ATF1, EWSR1-CREB1 or EWSR1-POU5F1 [13].…”

Section: Discussionmentioning

confidence: 99%

Obstructing Trachea Tumor: Myoepithelial Carcinoma about a Case

Kessab

Zegmout

Ochi

et al. 2021

ABCMed

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Myoepithelial carcinoma, also called malignant myoepithelioma, is an extremely rare tumor of the salivary gland type. It is defined as a malignant neoplasm in which the tumor cells exhibit exclusively myoepithelial differentiation. Our case is a 48-year-old patient with no specific history who was presented to the hospital emergency room for respiratory difficulty and dysphagia progressively evolving for 08 weeks. A cervical CT was done which revealed a hypodense tumor process in T1 of 4 cm long axis obstructing the trachea well limited and richly vascularized. The diagnosis of tracheal myoepithelial carcinoma was made after histological and immunohistochemical analysis on a biopsy pending analysis of the operative specimen. Treatment remains initially surgical with appropriate postoperative radiotherapy and chemotherapy.

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“…Radical resection with enough margin is a guarantee of oncological control for VS [6,21]. Unfortunately, all patients in our cohort were initially treated at community and none of them received wide resection at primary surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike other vulvar malignancies, VS usually grows with benign appearance and non-speci c manifestation, which increases the di culty of early diagnosis [5]. The biological behavior of VS is featured by frequent recurrence and high potential to metastasize, for which the initial treatment is quite important [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

Gu¹,

Liu²,

Liu³

et al. 2020

Preprint

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BackgroundValvar sarcoma is an extremely rare disease in which the data for treatment and prognosis are scarce. The aim of this study was to analysis the clinical features and treatment outcomes of initial and recurrent valvar sarcoma.MethodThe medical records of patients with initial or recurrent vulvar sarcoma treated at Sun Yat-sen University Cancer Center between January 2005 and April 2019 were retrospectively reviewed.Results A total of 21 patients with vulvar sarcoma were identified. The median age of them was 43 years (range: 16 to 71). The histological subtypes were epithelioid sarcoma, leiomyosarcoma, dermatofibrosarcoma protuberans, rhabdomyosarcoma, and angiosarcoma in 9, 4, 4, 3 and 1 patients, respectively. None of the patients received wide resection when they were initially treated at communities. Thirteen patients were referred immediately after initial managements (Group A), whereas 8 patients were referred with recurrent disease (Group B). Wide resections were performed with pathologically negative margins in 20 patients, of whom 9 also received lymphadenectomy and 3 showed metastases. One patient in Group B only received chemoradiotherapy for unresectable pelvic mass. Adjuvant chemoradiotherapy were performed for 12 patients evaluated to have high risk of recurrence. The median follow-up time was 39 months (range: 11 to 174) for Group A and 107 (range: 2 to 139) for Group B. During the follow-up, relapse occurred in 3 patients in Group A and 5 in Group B. The 3- and 5-year survival rates were 92.3% and 76.9% for Group A, 50.0% and 37.5% for Group B, respectively.ConclusionsVS is usually resected as benign disease at initial management. Immediate extended resection with negative margins provided favorable outcomes for most of the patients. The prognosis for recurrent cases were poor, however there remained survival opportunities if aggressive treatments were carried out.

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Myoepithelial carcinoma or epithelioid sarcoma – A rare diagnosis with poor prognosis. A case report and review of literature

Cited by 5 publications

References 14 publications

Primary myoepithelial carcinoma of the Vulva: Case of a rare tumor with malignant potential and review of literature

Primary myoepithelial carcinoma of the Vulva: Case of a rare tumor with malignant potential and review of literature

Obstructing Trachea Tumor: Myoepithelial Carcinoma about a Case

Clinical Features and Treatment Outcomes of Vulvar Sarcoma: A Single-Institution Review of 21 Cases

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