Myoepithelioma: Benign or malignant – A diagnostic dilemma

Gan, Boon Chye; Chin, Andrew R.; Mutalib, Nor Shahida Abd; Mamat, Hamidah; Yusop, Che Yusfarina Che; Rahman, Hisham Abdul

doi:10.1016/j.ejenta.2016.11.003

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…In contrast, malignant myoepithelioma (myoepithelial carcinoma), which is exclusively composed of undifferentiated myoepithelial cells, is more aggressive. 12,21,22,26,32 In humans, myoepithelial cells have been characterized for their tumorsuppressive functions, such as the release of several protease inhibitors and the expression of tumor-suppressive proteins. 9 However, a progressive switch into a less tumor-protective phenotype has been hypothesized when myoepithelial cells gradually lose their normal phenotype and organization.…”

Section: Discussionmentioning

confidence: 99%

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

et al. 2020

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Feline mammary tumors are usually malignant and aggressive carcinomas. Most cases are simple monophasic carcinomas (1 epithelial population), and additional phenotyping is usually not needed. In this study, we describe 10 malignant mammary tumors from 9 female cats that had unusual histomorphology: they appeared biphasic, with 2 distinct cell populations. Initially, they were morphologically diagnosed as either carcinosarcoma (1/10) or malignant pleomorphic tumor (9/10) of the mammary gland, as the latter did not match any previously described histological subtype. Immunohistochemistry (IHC) was performed for pancytokeratin, cytokeratins 8 and 18, cytokeratin 14, cytokeratins 5 and 6, vimentin, p63, calponin, alpha-smooth muscle actin, Ki-67, ERBB2, estrogen receptor alpha, and progesterone receptor. In 7 of 10 cases, the biphasic nature was confirmed and, on the basis of the IHC results, they were classified as carcinoma and malignant myoepithelioma (4/10), ductal carcinoma (1/10), and carcinosarcoma (2/10). The other 3 of 10 cases were monophasic based on IHC. In the cases of carcinoma and malignant myoepithelioma, the malignant myoepithelial cells were 100% positive for vimentin (4/4) and variably positive for p63, calponin, and cytokeratins (4/4). These findings show that, although rare, biphasic mammary carcinomas do occur in cats. In dogs and humans, tumors composed of malignant epithelial and myoepithelial cells have a less aggressive behavior than certain simple carcinomas, and therefore, their identification might also be clinically significant in the cat.

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Section: Discussionmentioning

confidence: 99%

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

et al. 2020

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“…Malignancy may be considered by virtue of the tumor cells to show high proliferative index/increased mitotic activity and infiltration. [ 18 ] We observed high mitotic activity of more than 7 per 10 high power fields. Nagao et al .…”

Section: Discussionmentioning

confidence: 80%

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

Gupta

Khare

Jain

et al. 2018

J Oral Maxillofac Pathol

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Myoepithelial carcinomas (MCs) are difficult to distinguish from their benign counterpart due to diverse morphology. This neoplasm was introduced by Stromeyer et al. in 1975. They comprise of <2% of all salivary gland carcinomas involving most commonly major salivary glands and are characterized by differentiation of tumor cells into myoepithelial cells. The cells may present as epithelioid, plasmacytoid, spindle, clear, stellate and mixed type predominantly. Literature search revealed very few cases reported as clear cell variant of MC. Here, we report a case of clear cell MC involving buccal vestibule extending up to alveolus. The diagnosis was confirmed, and the patient was surgically treated.

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Myoepithelioma: Benign or malignant – A diagnostic dilemma

Cited by 2 publications

References 13 publications

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

Biphasic Feline Mammary Carcinomas Including Carcinoma and Malignant Myoepithelioma

Clear cell myoepithelial carcinoma involving vestibule and alveolus: A rare case report with review of literature

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