Myofibroblastic Tumours: Neoplasias with Divergent Behaviour. Ultrastructural and Flow Cytometric Analysis

Biselli, Roberto; Boldrini, Renata; Ferlini, Cristiano; Boglino, C.; Inserra, Alessandro; Bosman, Cesare

doi:10.1016/s0344-0338(99)80127-7

Cited by 71 publications

(45 citation statements)

References 38 publications

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“…Some of the persistent uncertainties about IMT are whether it is a benign, indeterminate, or malignant neoplasm, whether it represents a neoplastic or reactive process, what is the significance of multifocal or metastatic disease, and whether histologic-prognostic features can be identified (2,7,8). Recent studies have suggested that the combination of ganglionlike cells, aneuploidy, and p53 expression are associated with more aggressive clinical behavior (5,6,35).…”

Section: Imt Is Classified With Intermediate Neoplasms In the Currentmentioning

confidence: 99%

ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor

et al. 2001

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Fluorescence in situ hybridization showed ALK rearrangements in nine cases (47%), aneuploidy in three cases (16%), and no rearrangement in seven cases (37%). IMTs with ALK abnormalities by immunohistochemistry and/or fluorescence in situ hybridization originated in the abdomen/pelvis/retroperitoneum, chest, and extremities. The mean age was 6.6 years, with a male/female ratio of 1.3. 64% of patients had no evidence of disease at last followup, 45% had one or more recurrences, and 18% displayed histologic evidence of malignant transformation. The IMTs without ALK abnormalities occurred in older children, were more frequent in females, and had fewer recurrences. However, in

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Section: Imt Is Classified With Intermediate Neoplasms In the Currentmentioning

confidence: 99%

ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor

et al. 2001

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“…However, no factors have been identified that reliably predict behavior in these tumors. It has been suggested that the presence of atypia, ganglion-like cells, p53 expression, and aneuploidy might be useful to identify IMT that might undergo pursue a more aggressive clinical course [138,139]. Surgical resection is the usual treatment for both primary and recurrent tumors.…”

Section: Inflammatory Myofibroblastic Tumormentioning

confidence: 99%

Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

Fisher

2004

Ultrastructural Pathology

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CaseMS is a 35 year old P1+0+0+1 who had cesarean section 6 months earlier. She presented with vaginal mass that was painless but causing difficult intercourse.

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confidence: 99%

Rectovaginal Septum as a Site for Recurrent Myofibroblastic Tumor (First Time Report)

Lotfi¹

2015

SOJGOW

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SOJ Gynecology, Obstetrics and Women's Health Open Access Case ReportThe outlook of this disease has changed with time from a benign reactive process to a malignant neoplasm, based on the multiple case reports demonstrating recurrent and constant clonal genetic alterations [7][8][9][10].IMT is a spindle cell proliferation that can histologically resemble various malignant mesenchymal neoplasms; however, it generally behaves as a benign or locally recurrent tumor. CaseMS is a 35 year old P1+0+0+1 who had cesarean section 6 months earlier. She presented with vaginal mass that was painless but causing difficult intercourse. She had been interviewed by general surgeon who found 8-10 cm mass related to the posterior vaginal wall. He had performed a laparotomy, trying to reach the mass through the pouch of Douglas and when he failed, he tried to have a biopsy which was insufficient and inconclusive. 3 weeks later she reported to our department, where examination showed an 8-10 cm sized mass between the rectum and posterior vaginal wall slightly shifted to the right side of the midline. The mass was not cystic but firm, mobile and not tender and extending from 2 cm above the introitus up to the level of posterior vaginal fornix. Rectal examination showed that the mass was in front of the rectum and upper part of the anal canal. A CT (Figure 1) and directed biopsy (Figure 2), was carried out and it showed 8-10 cm mass abutting the rectum but not infiltrating; the biopsy showed fibrous nature. Apart from that the patient gave no history of anything important and the examinations of all other systems were negative. She denied fever, her postpartum course had been uncomplicated and she was exclusively breast feeding since delivery. Laboratory data were unremarkable.Vaginal route exploration for excision of the mass was arranged. The posterior vaginal wall was dissected off the mass upwards the same way of doing rectocele repair. The mass was having a false capsule and this helped in its dissection from the posterior vaginal wall. To dissect the mass from the rectum and the anal canal, the assistant inserted his finger in the anal canal trying to push the mass forward and anteriorly to put it under tension to help in its dissection and in the meanwhile alarming if dissection went close to the rectum to avoid its injury (Figure 3 and Figure 4). Dissection continued and succeeded in taking the mass out ( Figure 5) and it was extending from the introitus up AbstractBackground: Myofibroblastic tumor (MT) is a neoplasm of unknown etiology, occurring at various sites but was not reported in the rectovaginal area. Literary it is composed of spindle cells (myofibroblasts). Usually it is associated with variable inflammatory component; hence the name is Inflammatory Myoblastic Tumor (IMT). The occurrence in the rectovaginal septum of female is almost unknown in the literature.

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Myofibroblastic Tumours: Neoplasias with Divergent Behaviour. Ultrastructural and Flow Cytometric Analysis

Cited by 71 publications

References 38 publications

ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor

ALK1 and p80 Expression and Chromosomal Rearrangements Involving 2p23 in Inflammatory Myofibroblastic Tumor

Low-grade Sarcomas with CD34-Positive Fibroblasts and Low-Grade Myofibroblastic Sarcomas

Rectovaginal Septum as a Site for Recurrent Myofibroblastic Tumor (First Time Report)

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