Myofibroblasts and mast cells: influences on biological behavior of odontogenic lesions

Pereira, Joabe dos Santos; Nóbrega, Fernando José de; Vasconcelos, Rodrigo Gadelha; Câmara, Adriana Costa de Souza Martins; Souza, Lélia Batista de; Queiroz, Lélia Maria Guedes

doi:10.1016/j.anndiagpath.2014.09.003

Cited by 13 publications

(14 citation statements)

References 46 publications

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“…Pereira et al found that mast cells secreted tryptase to promote the CAF‐induced transformation of prostate epithelia cell morphology in a micro‐tissue model . In ameloblastomas, the expression of myofibroblasts and mast cells was positively correlated, and this positive correlation was also correlated with the aggressiveness of cancer cells . This study showed that mast cells induced the differentiation fibroblasts into myofibroblasts and promoted myofibroblast proliferation .…”

Section: Crosstalk Between Cancer‐associated Fibroblasts and Immune Cellsmentioning

confidence: 62%

“…62 This study showed that mast cells induced the differentiation fibroblasts into myofibroblasts and promoted myofibroblast proliferation. 62 Yang et al found that mast cells and fibroblasts interact with each other to regulate the tumour phenotype in neurofibromatosis type 1 (NF1). 63 NF+/− mast cells secreted TGF-β, which promoted the proliferation of fibroblasts.…”

Section: Interaction Between Cancer-associated Fibroblasts and Mastmentioning

confidence: 91%

“…61 In ameloblastomas, the expression of myofibroblasts and mast cells was positively correlated, and this positive correlation was also correlated with the aggressiveness of cancer cells. 62 This study showed that mast cells induced the differentiation fibroblasts into myofibroblasts and promoted myofibroblast proliferation. 62 Yang et al found that mast cells and fibroblasts interact with each other to regulate the tumour phenotype in neurofibromatosis type 1 (NF1).…”

Section: Interaction Between Cancer-associated Fibroblasts and Mast Cellsmentioning

confidence: 91%

See 2 more Smart Citations

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Liu

Chen

et al. 2019

J Cellular Molecular Medi

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Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.

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Section: Crosstalk Between Cancer‐associated Fibroblasts and Immune Cellsmentioning

confidence: 62%

Section: Interaction Between Cancer-associated Fibroblasts and Mastmentioning

confidence: 91%

Section: Interaction Between Cancer-associated Fibroblasts and Mast Cellsmentioning

confidence: 91%

See 1 more Smart Citation

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Liu

Chen

et al. 2019

J Cellular Molecular Medi

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“…Thereby controlling lesion growth and vascular support through angiogenesis ( 10 , 16 ). Unfortunately, few studies on the presence of MF in odontogenic cysts are available ( 2 , 5 , 10 , 18 - 23 ) and only four address inflammatory odontogenic lesions ( 16 - 17 , 24 - 25 ).…”

Section: Discussionmentioning

confidence: 99%

Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair

de-Freitas

de-França²,

Gordón-Núñez³

et al. 2020

Med Oral

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Background Myofibroblasts (MF) and angiogenesis are important factors in the development and expansion of cystic lesions, where these cells secrete growth factors and proteases, stimulating angiogenesis, matrix deposition and cell migration, affecting the growth of these periapicopathies. The present study aimed to evaluate the immunohistochemical expression of CD34 and α-SMA in radicular cysts (RC) and residual radicular cysts (RRC), with the purpose of contributing to a better understanding of the expansion and progression of these periapical lesions. Material and Methods The present study os a descriptive, quantitative and comparative analysis of positive CD34 and α-SMA immunohistochemical expressions in 30 RC and 30 RRC specimens. α-SMA expression was evaluated in the fibrous capsule of the lesions, at 100x magnification below the epithelial lining. A total of 10 higher immunostaining fields were selected and subsequently, positive cells were quantified at 400x magnification, averaged per field. Regarding the angiogenic index, immuno-labeled microvessel counts for the anti-CD34 antibody were performed in 10 fields at 200x magnification. Results Statistically significant differences regarding α-SMA immunostaining were observed ( p = 0.035), as well as a correlation between α-SMA versus CD34 ( p = 0.004) in RRC. However, the angiogenic index obtained by immunostaining for CD34 indicated no statistical difference between lesions. Intense inflammatory infiltrates were predominant in RC, while mild and moderate degrees were more commonly observed in RRC ( p <0.001). Intense inflammatory infiltrates were also more often noted in larger RRC ( p = 0.041). Inflammatory infiltrates showed no significant correlation with α-SMA and CD34 immunostaining. Conclusions The results indicate that the significant correlation found between the presence of MF and the angiogenic index are related to the repair process in RRC. Key words: Myofibroblasts, angiogenesis, inflammatory odontogenic cysts.

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“…Excess numbers of CAFs and MCs in tumor islets are strongly associated with the aggressiveness of cancer, and their interactions directly contribute to tumor progression [ 172 , 173 ]. In prostate cancer, with the overexpression of estrogen inside, CAFs can potentiate MC proliferation, migration and inflammatory cytokine secretion and thus exhibit protumorigenic effects [ 174 ].…”

Section: Interaction Between Cafs and The Immune Microenvironment In Tumorsmentioning

confidence: 99%

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

et al. 2021

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Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tumor growth, angiogenesis, invasion and metastasis, along with extracellular matrix (ECM) remodeling and even chemoresistance. Numerous previous studies have confirmed the critical role of the interaction between CAFs and tumor cells in tumorigenesis and development. However, recently, the mutual effects of CAFs and the tumor immune microenvironment (TIME) have been identified as another key factor in promoting tumor progression. The TIME mainly consists of distinct immune cell populations in tumor islets and is highly associated with the antitumor immunological state in the TME. CAFs interact with tumor-infiltrating immune cells as well as other immune components within the TIME via the secretion of various cytokines, growth factors, chemokines, exosomes and other effector molecules, consequently shaping an immunosuppressive TME that enables cancer cells to evade surveillance of the immune system. In-depth studies of CAFs and immune microenvironment interactions, particularly the complicated mechanisms connecting CAFs with immune cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding the direct and indirect crosstalk between CAFs and infiltrating immune cells and further summarize the possible immunoinhibitory mechanisms induced by CAFs in the TME. In addition, we present current related CAF-targeting immunotherapies and briefly describe some future perspectives on CAF research in the end.

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Myofibroblasts and mast cells: influences on biological behavior of odontogenic lesions

Cited by 13 publications

References 46 publications

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Myofibroblasts and increased angiogenesis contribute to periapical cystic injury containment and repair

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

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