Myogenic control of intestinal motility.

Bortoff, Alexander

doi:10.1152/physrev.1976.56.2.418

Cited by 72 publications

(19 citation statements)

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“…Bursting, based on slow voltage waves, is a well-known feature of pacemaker neurons [10,15,30,32], but is also shown by many other cells, like cold-receptors of the skin [11], some types of smooth muscle cell [9] and insulinzsecreting B-cells [5,59]. Furthermore, fibroblasts show slow voltage oscillations [71] and cochlear hair-cells fast voltage oscillations [19], whose origin seems related to that of pacemaker potentials.…”

Section: Voltage Response To Odorantsmentioning

confidence: 99%

Odorant response of isolated olfactory receptor cells is blocked by amiloride

Frings

Lindemann

1988

J. Membrain Biol.

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Olfactory receptor cells were isolated from the nasal mucosa of Rana esculenta and patch clamped. Best results were obtained with free-floating cells showing ciliary movement. 1) On-cell mode: Current records were obtained for up to 50 min. Under control conditions they showed only occasional action potentials. The odorants cineole, amyl acetate and isobutyl methoxypyrazine were applied in saline by prolonged superfusion. At 500 nanomolar they elicited periodic bursts of current transients arising from cellular action potentials. The response was rapidly, fully and reversibly blocked by 50 microM amiloride added to the odorant solution. With 10 microM amiloride, the response to odorants was only partially abolished. 2) Whole-cell mode: Following breakage of the patch, the odorant response was lost within 5 to 15 min. Prior to this, odorants evoked a series of slow transient depolarizations (0.1/sec, 45 mV peak to peak) which reached threshold and thus elicited the periodic discharge of action potentials. These slow depolarizing waves were reversibly blocked by amiloride, which stabilized the membrane voltage between -80 and -90 mV. We conclude that amiloride inhibits chemosensory transduction of olfactory receptor cells, probably by blocking inward current pathways which open in response to odorants.

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Section: Voltage Response To Odorantsmentioning

confidence: 99%

Odorant response of isolated olfactory receptor cells is blocked by amiloride

Frings

Lindemann

1988

J. Membrain Biol.

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“…A brief introduction to some of the basic concepts is provided here. The reader is referred to some of the more exten sive review articles for complete details [1][2][3][4][5].…”

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confidence: 99%

Gastrointestinal Motility: Some Basic Concepts

Sarna

Otterson

1988

Pharmacology

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The spatial and temporal patterns of phasic contractions in the gastrointestinal tract are regulated by a complex interplay between the myogenic, neural and chemical control mechanisms. These contractions are largely responsible for the mixing and propulsive movements of the gut after a meal. In the fasted state, organized groups of contractions called cyclic motor activity and migrating motor complex keep the upper digestive tract clean of residual food and debris. In addition, the small intestine and the colon generate giant migrating contractions which are several-fold stronger than the postprandial phasic contractions and migrate uninterrupted over long distances. The giant migrating contractions are effective in rapid propulsion. The upper small intestine and the antrum generate retrograde giant contractions that generally precede vomiting.

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“…The choice of using this segment was based on a series of physiopathological and anatomical considerations. The motility of the intestine is a key element in urinary continence: physiopathological studies have demonstrated that the greatest control over intestinal motility comes from the frequency of the electrical activity of the intestine, that is, myogenic control [103,104]. Physiological studies have proved that the ileocecal segment has less electrical activity and therefore, theoretically, less motor activity [105].…”

Section: Experience In Malesmentioning

confidence: 99%

Bladder replacement in women: A new experience

et al. 1997

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Bladder replacement in women in a new experience. In this article the authors reviewed in a critical way the patho-physiological principles involved in the previous male bladder replacement techniques and the results achieved both leading to the recent experience of bladder replacement in women. The authors present the recent acquirements about pelvic surgical anatomy and postcystectomy oncological radicality in female, and the more common surgical techniques for building a neobladder in women with the results achieved up to now. They also examined the problems arising from this exciting but precocious experience which will surely involve the urological community in the future.

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Myogenic control of intestinal motility.

Cited by 72 publications

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Odorant response of isolated olfactory receptor cells is blocked by amiloride

Odorant response of isolated olfactory receptor cells is blocked by amiloride

Gastrointestinal Motility: Some Basic Concepts

Bladder replacement in women: A new experience

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