Myogenic regulatory factor (MRF) expression is affected by exercise in postnatal chicken skeletal muscles

Yin, Huadong; Li, Diyan; Zhao, Xiaoling; Liu, Yiping; Yang, Zhiqin; Zhu, Qing

doi:10.1016/j.gene.2015.02.044

Cited by 19 publications

(9 citation statements)

References 38 publications

(36 reference statements)

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“…Among these DEGs, importantly, MYOG and MYOD were up-regulated in QHMM, while MYF6 was down-regulated. Previous studies showed that MYOG , MYOD and MYF6 are regulatory factors belonging to the muscle regulatory factors (MRFs) family, which has central functions in early muscle differentiation, and muscle growth and development 23 24 . MYOG and MYF6 are involved mainly in the fusion and differentiation of myoblast 25 26 .…”

Section: Discussionmentioning

confidence: 99%

Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

Bai

Xiang

Zhang

et al. 2016

Sci Rep

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The Qianhua Mutton Merino (QHMM) is a new sheep (Ovis aries) variety with better meat performance compared with the traditional local variety Small Tail Han (STH) sheep. We aimed to evaluate the transcriptome regulators associated with muscle growth and development between the QHMM and STH. We used RNA-Seq to obtain the transcriptome profiles of the longissimus muscle from the QHMM and STH. The results showed that 960 genes were differentially expressed (405 were up-regulated and 555 were down-regulated). Among these, 463 differently expressed genes (DEGs) were probably associated with muscle growth and development and were involved in biological processes such as skeletal muscle tissue development and muscle cell differentiation; molecular functions such as catalytic activity and oxidoreductase activity; cellular components such as mitochondrion and sarcoplasmic reticulum; and pathways such as metabolic pathways and citrate cycle. From the potential genes, a gene-act-network and co-expression-network closely related to muscle growth and development were identified and established. Finally, the expressions of nine genes were validated by real-time PCR. The results suggested that some DEGs, including MRFs, GXP1 and STAC3, play crucial roles in muscle growth and development processes. This genome-wide transcriptome analysis of QHMM and STH muscle is reported for the first time.

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Section: Discussionmentioning

confidence: 99%

Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

Bai

Xiang

Zhang

et al. 2016

Sci Rep

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“…A primary signaling pathway by which myostatin exerts its deleterious effects on muscle is through the activation of Smad proteins which lead [221] to the downregulation of myogenic regulating factors (MRFs) [222]. Hyperplasia and hypertrophy mechanisms in muscle growth are controlled by the sequential expression of MRFs [223]. Both acute and chronic exercise is effective in reducing myostatin while subsequently up-regulating myogenin and myogenic differentiation factor D (MyoD) [224, 225, 223, 226, 31].…”

Section: Introductionmentioning

confidence: 99%

“…Hyperplasia and hypertrophy mechanisms in muscle growth are controlled by the sequential expression of MRFs [223]. Both acute and chronic exercise is effective in reducing myostatin while subsequently up-regulating myogenin and myogenic differentiation factor D (MyoD) [224, 225, 223, 226, 31]. Furthermore, 16 weeks of resistance training, three days/week, resulted in increased skeletal muscle mass, myogenin, and MyoD in healthy men and women [227].…”

Section: Introductionmentioning

confidence: 99%

The Role of Systemic Inflammation in Cancer‐Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention

Cole

Kleckner

Jatoi

et al. 2018

JCSM Clinical Reports

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Progressive skeletal muscle wasting in cancer cachexia involves a process of dysregulated protein synthesis and breakdown. This catabolism may be the result of mal-nutrition, and an upregulation of both pro-inflammatory cytokines and the ubiquitin proteasome pathway (UPP), which can subsequently increase myostatin and activin A release. The skeletal muscle wasting associated with cancer cachexia is clinically significant, it can contribute to treatment toxicity or the premature discontinuation of treatments resulting in increases in morbidity and mortality. Thus, there is a need for further investigation into the pathophysiology of muscle wasting in cancer cachexia to develop effective prophylactic and therapeutic interventions. Several studies have identified a central role for chronic-systemic inflammation in initiating and perpetuating muscle wasting in patients with cancer. Interestingly, while exercise has shown efficacy in improving muscle quality, only recently have investigators begun to assess the impact that exercise has on chronic-systemic inflammation. To put this new information into context with established paradigms, here we review several biological pathways (e.g. dysfunctional inflammatory response, hypothalamus pituitary adrenal axis, and increased myostatin/activin A activity) that may be responsible for the muscle wasting in patients with cancer. Additionally, we discuss the potential impact that exercise has on these pathways in the treatment of cancer-related muscle wasting. Exercise is an attractive intervention for muscle wasting in this population, partially because it disrupts chronic-systemic inflammation mediated catabolism. Most importantly, exercise is a potent stimulator of muscle synthesis, and therefore this therapy may reverse muscle damage caused by cancer cachexia.

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“…The gene is located in Chromosome 18 and has118,864 bp length including 22 exons, 21 introns and several unknown sequence gaps (http://asia.ensembl.org/). A large number of researches have conducted studies on rabbit meat quality traits at a molecular level and identified single nucleotide polymorphisms in the MSTN, MC4R, POU1F1, CAST, Myf5 and MYf6 genes that were associated with meat traits (Jiang et al 2008;Yin et al 2011;Fontanesi et al 2013;Qiao et al 2014;Sternstein et al 2014;Wang et al 2015;Yin et al 2015;Wang et al 2016Wang et al , 2017. However, none of these studies considered associations between MYPN SNPs and rabbit meat quality traits.…”

Section: Introductionmentioning

confidence: 99%

Myopalladin gene polymorphism is associated with rabbit meat quality traits

Wang

Shi

Elzo

et al. 2017

Italian Journal of Animal Science

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The objective of this study was to investigate the effect of the polymorphism in the Myopalladin (MYPN) gene on meat quality traits in the Hyla, Champagne, Tianfu Black rabbit breeds using PCR and DNA sequencing. A novel SNP (g.18497416 G > A) was found at 229 bp in exon 13 of chromosome 18. The three rabbit populations had intermediate levels of genetic diversity according to their polymorphism information content values. The statistical analysis indicated that rabbits with the GG genotype had a significantly greater a Ã 24h and b Ã 24h than rabbits with the AA genotype (p < .05) in the longissimus dorsi muscle and that animals with the AA genotype had substantially higher a Ã 0h and a Ã 24h than those with the AG genotype (p < .05) in the biceps femoris muscle. The rabbits with the AA genotype had the highest intramuscular fat (IMF) values and those with the GG genotype had the lowest IMF values in both longissimus dorsi and biceps femoris muscles. These results indicated that MYPN could be considered as candidate genes for genetic improvement of rabbit meat traits.

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Myogenic regulatory factor (MRF) expression is affected by exercise in postnatal chicken skeletal muscles

Cited by 19 publications

References 38 publications

Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

Comparative transcriptome profiling of longissimus muscle tissues from Qianhua Mutton Merino and Small Tail Han sheep

The Role of Systemic Inflammation in Cancer‐Associated Muscle Wasting and Rationale for Exercise as a Therapeutic Intervention

Myopalladin gene polymorphism is associated with rabbit meat quality traits

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