Myogenin is a positive regulator of MEGF10 expression in skeletal muscle

Park, Seung Yoon; Yun, Youngeun; Kim, Mi Jin; Kim, In San

doi:10.1016/j.bbrc.2014.07.061

Cited by 21 publications

(15 citation statements)

References 21 publications

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“…SDF2 L1, MAPK1 and mir301b are involved in the processing of a wide range of defensins (Meredith et al 2013). We also detected MEGF10, which encodes a protein that regulates the myogenesis of satellite cells in skeletal muscles (Park et al 2014), and CRIM1, which is located close to a QTL on Chr11 and encodes an insulin-like growth factor-binding domain (Kolle et al 2000).…”

Section: Cnvr Gene Contents and Functional Annotationsmentioning

confidence: 80%

Genome-wide detection of copy-number variations in local cattle breeds

et al. 2019

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Abstract. The aim of the present study was to identify copy-number variations (CNVs) in Cinisara (CIN) and Modicana (MOD) cattle breeds on the basis of signal intensity (logR ratio) and B allele frequency of each marker, using Illumina's BovineSNP50K Genotyping BeadChip. The CNVs were detected with the PennCNV and SVS 8.7.0 software and were aggregated into CNV regions (CNVRs). PennCNV identified 487 CNVs in CIN that aggregated into 86 CNVRs, and 424 CNVs in MOD that aggregated into 81 CNVRs. SVS identified a total of 207 CNVs in CIN that aggregated into 39 CNVRs, and 181 CNVs in MOD that aggregated into 41 CNVRs. The CNVRs identified with the two softwares contained 29 common CNVRs in CIN and 17 common CNVRs in MOD. Only a small number of CNVRs identified in the present study have been identified elsewhere, probably because of the limitations of the array used. In total, 178 and 208 genes were found within the CNVRs of CIN and MOD respectively. Gene Ontology and KEGG pathway analyses showed that several of these genes are involved in milk production, reproduction and behaviour, the immune response, and resistance/susceptibility to infectious diseases. Our results have provided significant information for the construction of more-complete CNV maps of the bovine genome and offer an important resource for the investigation of genomic changes and traits of interest in the CIN and MOD cattle breeds. Our results will also be valuable for future studies and constitute a preliminary report of the CNV distribution resources in local cattle genomes.

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Section: Cnvr Gene Contents and Functional Annotationsmentioning

confidence: 80%

Genome-wide detection of copy-number variations in local cattle breeds

et al. 2019

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“…MEGF10 together with myogenin regulates the satellite cells’ myogenesis in skeletal muscles (Park et al . ). Moreover, SNPs within this gene are connected with myopathy in humans (Boyden et al .…”

Section: Discussionmentioning

confidence: 97%

“…In the present research, other two growth factors -MEGF10 and FGF6were identified and proposed to be related to the Limousin breed phenotypehigh carcass yield, high meat to bone ratios and a low fat content. MEGF10 together with myogenin regulates the satellite cells' myogenesis in skeletal muscles (Park et al 2014). Moreover, SNPs within this gene are connected with myopathy in humans (Boyden et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Identification of genome‐wide selection signatures in the Limousin beef cattle breed

Gurgul

Szmatoła

Ropka‐Molik

et al. 2015

J Animal Breeding Genetics

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The study is aimed at identifying selection footprints within the genome of Limousin cattle. With the use of Extended Haplotype Homozygosity test, supplemented with correction for variation in recombination rates across the genome, we created map of selection footprints and detected 173 significant (p < 0.01) core haplotypes being potentially under positive selection. Within these regions, a number of candidate genes associated inter alia with skeletal muscle growth (GDF15, BMP7, BMP4 and TGFB3) or postmortem proteolysis and meat maturation (CAPN1 and CAPN5) were annotated. Noticeable clusters of selection footprints were detected on chromosomes 1, 4, 8 and 14, which are known to carry several quantitative trait loci for growth traits and meat quality. The study provides information about the genes and metabolic pathways potentially modified under the influence of directional selection, aimed at improving beef production characteristics in Limousin cattle.

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“…MyoD directly binds to MEF2 and enhances MEF2-dependent transcription through its own transcriptional activities, which results in the cooperative enhancement of MEF2-and MyoDdependent myogenic differentiation (38). Myogenin has been proven to play a critical role in the transcriptional regulation of the multiple epidermal growth factor-like-domains 10 (MEGF10) gene, a well-known myogenic regulator of satellite cells (39). Both MyoD and myogenin bind to E-box elements in the promoter region of muscle-specific genes and regulate their expression in skeletal muscle (40).…”

Section: Discussionmentioning

confidence: 99%

Folic acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway

Hwang

Kang

Sung

et al. 2015

International Journal of Molecular Medicine

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Folic acid is a water-soluble vitamin in the B-complex group, and an exogenous intake is required for health, growth and development. As a precursor to co-factors, folic acid is required for one-carbon donors in the synthesis of DNA bases and other essential biomolecules. A lack of dietary folic acid can lead to folic acid deficiency and can therefore result in several health problems, including macrocytic anemia, elevated plasma homocysteine levels, cardiovascular disease, birth defects, carcinogenesis, muscle weakness and difficulty in walking. Previous studies have indicated that folic acid exerts a positive effect on skeletal muscle functions. However, the precise role of folic acid in skeletal muscle cell differentiation remains poorly understood. Thus, in the present study, we examined the effects of folic acid on neo-myotube maturation and differentiation using C2C12 murine myoblasts. We found that folic acid promoted the formation of multinucleated myotubes, and increased the fusion index and creatine kinase (CK) activity in a concentration-dependent manner. In addition, western blot analysis revealed that the expression levels of the muscle-specific marker, myosin heavy chain (MyHC), as well as those of the myogenic regulatory factors (MRFs), MyoD and myogenin, were increased in the folic acid-treated myotubes during myogenic differentiation. Folic acid also promoted the activation of the Akt pathway, and this effect was inhibited by treatment of the C2C12 cells with LY294002 (Akt inhibitor). Blocking of the Akt pathway with a specific inhibitor revealed that it was necessary for mediating the stimulatory effects of folic acid on muscle cell differentiation and fusion. Taken together, our data suggest that folic acid promotes the differentiation of C2C12 cells through the activation of the Akt pathway.

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Myogenin is a positive regulator of MEGF10 expression in skeletal muscle

Cited by 21 publications

References 21 publications

Genome-wide detection of copy-number variations in local cattle breeds

Genome-wide detection of copy-number variations in local cattle breeds

Identification of genome‐wide selection signatures in the Limousin beef cattle breed

Folic acid promotes the myogenic differentiation of C2C12 murine myoblasts through the Akt signaling pathway

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