Myoglobin facilitates oxygen delivery during cardiac arrest

Kenwright, DN; Loiselle, Denis S.

doi:10.1016/s0022-2828(86)80648-4

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“…Two recent reports confirm this result. Kenwright and Loiselle (1986), using an isolated, Langendorif-circulated, saline-perfused guinea-pig heart in a state of electrical and mechanical arrest, found that nitrite poisoning of myoglobin reduced oxygen consumption only when arterial P02 was 70 torr or less. Similarily, Taylor et al (t 986), using nuclear magnetic resonance techniques, showed a diminution of high energy phosphate metabolism in the isolated rat heart, subsequent to inhibition of myoglobin function, only when arterial oxygen concentration was low (100,mol* 1-').…”

Section: Implications Of the Modelmentioning

confidence: 99%

The effect of myoglobin-facilitated oxygen transport on the basal metabolism of papillary muscle

Loiselle¹

1987

Biophysical Journal

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A mathematical model of oxygen diffusion into cylindrical papillary muscles is presented. The model partitions total oxygen flux into its simple and myoglobin-facilitated components. The model includes variable sigmoidal, exponential, or hyperbolic functions relating oxygen partial pressure to both fractional myoglobin saturation and rate of oxygen consumption. The behavior of the model was explored for a variety of saturation- and consumption-concentration relations. Facilitation of oxygen transport by myoglobin was considerable as indexed both by the elevation of oxygen partial pressure on the longitudinal axis of the muscle and by the fraction of total oxygen flux at the muscle center contributed by oxymyoglobin. Despite its facilitation of oxygen flux at the muscle center, myoglobin made only a negligible contribution to the total oxygen consumption averaged over the muscle cross-section. Hence the presence of myoglobin fails to explain either the experimentally determined basal metabolism-muscle radius relation or the stretch effect observed in isolated papillary muscle.

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Section: Implications Of the Modelmentioning

confidence: 99%

The effect of myoglobin-facilitated oxygen transport on the basal metabolism of papillary muscle

Loiselle¹

1987

Biophysical Journal

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show abstract

Myoglobin facilitates oxygen delivery during cardiac arrest

Cited by 1 publication

References 0 publications

The effect of myoglobin-facilitated oxygen transport on the basal metabolism of papillary muscle

The effect of myoglobin-facilitated oxygen transport on the basal metabolism of papillary muscle

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