Myoglobin for Early Risk Stratification of Emergency Department Patients with Possible Myocardial Ischemia

Abstract

Abstract. Objectives: To determine and compare the prognostic abilities of early, single-sample myoglobin measurement with that of creatine kinase-MB (CK-MB), with cardiac troponin T (cTnT), and with physician judgment in the absence of marker results among emergency department (ED) patients with possible myocardial ischemia. Methods: Prospective collection of clinical and serologic data using an identity-unlinked technique from patients with possible myocardial ischemia at two urban EDs. Outcome data concerning the occurrence of adverse events (AEs) during the 14 days after enrollment were used to calculate and compare the relative risks (RRs) Conclusions:The early prognostic sensitivity of myoglobin may allow identification of some high-risk patients missed by physician judgment, CK-MB, and cTnT. Myoglobin should be considered for use in the ED based on both its diagnostic and prognostic abilities.

Clinical significance of myoglobin and troponin-T in short-lasting severe myocardial ischemia

“…Troponins are useful diagnostic tools in the acute coronary syndrome [10,11]. Previous studies have found that an increased short and long-term risk of cardiac events and death is associated with elevated levels of serum troponins [7][8][9][10][11]13,14]. Despite the huge number of publications about chemistry, clinical and prognostic value of cardiac troponins in myocardial infarction, their role in short-lasting ischemia and stable angina pectoris, respectively, is not well known.…”

Photodynamic Therapy for Atherosclerosis

“…Additionally, myoglobin may be involved in the recruitment and activation of immune cells, such as macrophages, which play a role in the inflammatory response associated with atherosclerosis. The exact mechanisms by which myoglobin influences atherosclerosis are not fully understood, and research in this area is ongoing [64][65][66]. Troponin T (Figure 4) is a protein primarily known for its role in muscle contraction, particularly in cardiac muscle.…”