Myoglobin in the quadriceps femoris muscle of competitive cyclists and untrained men

Jansson, Eva; Sylvén, Christer; Nordevang, E

doi:10.1111/j.1748-1716.1982.tb07035.x

Cited by 45 publications

(15 citation statements)

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“…This is a unique observation that has not been previously documented, possibly in part due to the typically short-term interventional approaches that have been employed in the past (25,33,50). In contrast, the current investigation studied subjects who were either long-term sprint or endurance trained.…”

Section: Discussionmentioning

confidence: 90%

“…Previously, several investigators have utilized endurance training to promote aerobic adaptations and evaluated the effect on [Mb]. The majority of such interventional studies have failed to augment [Mb] in humans (25,33,50). Terrados et al (52) however, have demonstrated an increased Mb mRNA and protein level after endurance training, but only under hypobaric conditions.…”

Section: Role Of Mb In Human Skeletal Musclementioning

confidence: 99%

“…Additionally, in nature there are clear variations in Mb concentration ([Mb]) that support the role of Mb in the flux of O 2 from blood to aerobically active muscle: breast muscle of the nonflying chicken is white and lacks this protein, whereas the breast muscle of ducks and geese (which can fly) is red and rich in Mb (28). Interventional studies that have attempted to increase [Mb] with endurance training have been successful in rats (37) but have been unsuccessful in humans (25,33,50).…”

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confidence: 99%

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Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study

Bourrilhon¹,

Raynaud²,

Wary³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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. Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study. Am J Physiol Regul Integr Comp Physiol 287: R1441-R1449, 2004 doi:10.1152/ajpregu.00242.2004In human muscle the role of myoglobin (Mb) and its relationship to factors such as muscle perfusion and metabolic capacity are not well understood. We utilized nuclear magnetic resonance (NMR) to simultaneously study the Mb concentration ([Mb]), perfusion, and metabolic characteristics in calf muscles of athletes trained long term for either sprint or endurance running after plantar flexion exercise and cuff ischemia. The acquisitions for 1 H assessment of Mb desaturation and concentration, arterial spin labeling measurement of muscle perfusion, and 31 P spectroscopy to monitor high-energy phosphate metabolites were interleaved in a 4-T magnet. The endurance-trained runners had a significantly elevated [Mb] (0.28 Ϯ 0.06 vs. 0.20 Ϯ 0.03 mmol/kg). The time constant of creatine rephosphorylation (PCr), an indicator of oxidative capacity, was both shorter in the endurance-trained group (34 Ϯ 6 vs. 64 Ϯ 20 s) and negatively correlated with [Mb] across all subjects (r ϭ 0.58). The time to reach maximal perfusion after cuff release was also both shorter in the endurance-trained group (306 Ϯ 74 vs. 560 Ϯ 240 s) and negatively correlated with [Mb] (r ϭ 0.56). Finally, Mb reoxygenation rate tended to be higher in the endurance-trained group and was positively correlated with PCr (r ϭ 0.75). In summary, these NMR data reveal that [Mb] is increased in human muscle with a high oxidative capacity and a highly responsive vasculature, and the rate at which Mb resaturates is well correlated with the rephosphorylation rate of Cr, each of which support a teleological role for Mb in O 2 transport within highly oxidative human skeletal muscle.

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Section: Discussionmentioning

confidence: 90%

Section: Role Of Mb In Human Skeletal Musclementioning

confidence: 99%

mentioning

confidence: 99%

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Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study

Bourrilhon¹,

Raynaud²,

Wary³

et al. 2004

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Medbo et al (1988) and Saltin (1986) have indicated that about 10% of the energy supplied during the oxygen deficit comes from stored oxygen. Though rats can increase myoglobin concentrations drastically with training (Pattengale and Holloszy, 1967;Harms and Hickson, 1983), this has yet to be shown in humans (Jansson et al, 1982;Jacobs et al, 1987).…”

Section: Further Contributions To Anaerobic Energy Expenditurementioning

confidence: 99%

The maximally accumulated oxygen deficit as an indicator of anaerobic capacity

Scott

Roby

Lohman³

et al. 1991

Medicine and Science in Sports and Exercise

120

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The most advanced technology has been used to photograph and reproduce this manuscript from the microfilm master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand corner and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. STATEMENT BY AUTHORThis thesis has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the Library.Brief quotations from this thesis are allowable without special permission, provided that accurate acknowledgement of source is made. Requests for permission for extended quotation from or reproduction of this manuscript in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances, however, permission must be obtained from the author. Table 3 Means and Standard Deviations Among Groups 47 Table 4 Anaerobic Correlations for Total Sample 52 ABSTRACTThe purpose of this study was to determine whether maximally accumulated oxygen deficit (OD) was a valid index of anaerobic capacity by distinguishing among groups of aerobically and anaerobically trained athletes. In addition, OD was correlated with commonly used anaerobic capacity/power measures. Subjects were four distance and five middle distance runners, three sprinters, and four controls. Subjects performed one 2-3 minute supra-maximal treadmill run in which blood lactates were recorded, aWingate Bicycle Ergometer Test, and runs of 300, 400, and 600 meters. Data were analyzed by ANOVA and a Duncan's Multiple Range test. Significant differences in OD were found between: sprinters and middle distance runners vs. distance runners and controls suggesting a greater anaerobic capacity in the former t...

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“…Myoglobin (Mb) has been thought to relate to oxidative metabolism and to have several roles ± facilitated diusion, oxygen storing and mediation of oxidative phosphorylation (Wittenberg 1970;Kagen 1973;Cole 1982;Gayeski et al 1985;Wittenberg and Wittenberg 1989), and the Mb concentration ([Mb]) has been found to be associated with mitochondrial enzyme activity (Wittenberg 1970) and with the capillary supply (Reis and Wooten 1970). The adaptation of Mb in response to exercise has been studied solely in conditions of endurance training in animals (Hickson 1981;Hickson and Rosenkoetter 1981;Harms and Hickson 1983;Beyer and Fattore 1984;Hickson et al 1984) and humans (Jansson and SylveÂ n 1981;Jansson et al 1982Jansson et al , 1983MoÈ ller and Brandt 1982;Svedenhag et al 1983;SylveÂ n et al 1984). The [Mb] in rat skeletal muscles has been shown to be increased by endurance training, although that in human skeletal muscle was not.…”

Section: Introductionmentioning

confidence: 97%

Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training

Masuda

Choi

Shimojo

et al. 1999

European Journal of Applied Physiology

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The aim of this study was to determine the effects of 8 weeks of resistance training (RT) on the myoglobin concentration ([Mb]) in human skeletal muscle, and to compare the change in the [Mb] in two different RT protocols. The two types of protocol used were interval RT (IRT) of moderate to low intensity with a high number of repetitions and a short recovery time, and repetition RT (RRT) of high intensity with a low number of repetitions and a long recovery time. A group of 11 healthy male adults voluntarily participated in this study and were divided into IRT (n = 6) and RRT (n = 5) groups. Both training protocols were carried out twice a week for 8 weeks. At the completion of the training period, the one-repetition maximal force values and isometric force were increased significantly in all the subjects, by about 38.8% and 26.0%, respectively (P < 0.01). The muscle fibre composition was unchanged by the 8 weeks of training. The muscle fibre cross-sectional areas were increased significantly by both types of training in all fibre types (I, IIa and IIb, mean + 16.1 %, P < 0.05). The [Mb] showed no significant changes at the completion of the training [IRT from 4.63 (SD 0.63) to 4.48 (SD 0.72), RRT from 4.47 (SD 0.75) to 4.24 (SD 0.80) mg x g(-1) wet tissue] despite a significant decrease in citrate synthase activity [IRT from 5.27 (SD 1.45) to 4.49 (SD 1.48), RRT from 5.33 (SD 2.09) to 4.85 (SD 1.87) micromol x min(-1) x g(-1) wet tissue; P < 0.05] observed after both protocols. These results suggested that myoglobin and mitochondria enzymes were regulated by different mechanisms in response to either type of RT. Moreover, the maintained [Mb] in hypertrophied muscle should preserve oxygen transport from capillaries to mitochondria even when diffusion distance is increased.

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Myoglobin in the quadriceps femoris muscle of competitive cyclists and untrained men

Cited by 45 publications

References 13 publications

Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study

Metabolic and vascular support for the role of myoglobin in humans: a multiparametric NMR study

The maximally accumulated oxygen deficit as an indicator of anaerobic capacity

Maintenance of myoglobin concentration in human skeletal muscle after heavy resistance training

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