Myoid hamartomas of the breast

Daroca, Philip J.; Reed, Richard J.; Love, Gordon L.; Kraus, Steven D.

doi:10.1016/s0046-8177(85)80004-6

Cited by 44 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5][6][7][8][9] Smooth muscle hamartoma of the breast parenchyma entails bundles of non-atypical smooth muscle present within the breast parenchyma between the lobules, often along with fibrous stroma and scattered fat cells. 10 …”

Section: Smooth Muscle Hamartomamentioning

confidence: 99%

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Miettinen

2014

Modern Pathology

View full text Add to dashboard Cite

Smooth muscle tumors are here considered an essentially dichotomous group composed of benign leiomyomas and malignant leiomyosarcomas. Soft tissue smooth muscle tumors with both atypia and mitotic activity are generally diagnosed leiomyosarcomas acknowledging potential for metastasis. However, lesions exist that cannot be comfortably placed in either category, and in such cases the designation 'smooth muscle tumor of uncertain biologic potential' is appropriate. The use of this category is often necessary with limited sampling, such as needle core biopsies. Benign smooth muscle tumors include smooth muscle hamartoma and angioleiomyoma. A specific category of leiomyomas are estrogen-receptor positive ones in women. These are similar to uterine leiomyomas and can occur anywhere in the abdomen and abdominal wall. Leiomyosarcomas can occur at any site, although are more frequent in the retroperitoneum and proximal extremities. They are recognized by likeness to smooth muscle cells but can undergo pleomorphic evolution ('dedifferentiation'). Presence of smooth muscle actin is nearly uniform and desmin-positivity usual. This and the lack of KIT expression separate leiomyosarcoma from GIST, an important problem in abdominal soft tissues. EBVassociated smooth muscle tumors are a specific subcategory occurring in AIDS or post-transplant patients. These tumors can have incomplete smooth muscle differentiation but show nuclear EBER as a diagnostic feature. In contrast to many other soft tissue tumors, genetics of smooth muscle tumors are poorly understood and such diagnostic testing is not yet generally applicable in this histogenetic group. Leiomyosarcomas are known to be genetically complex, often showing 'chaotic' karyotypes including aneuploidy or polyploidy, and no recurrent tumor-specific translocations have been detected.

show abstract

Section: Smooth Muscle Hamartomamentioning

confidence: 99%

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Miettinen

2014

Modern Pathology

View full text Add to dashboard Cite

show abstract

“…Various theories describing the origin of smooth muscle cells have attempted to explain the histogenesis of MH lesions [2,8,15]. In general, it is thought that the smooth muscle component in MH could originate from the smooth muscle cells of vessels, the nipple [11], undifferentiated breast tissue stroma [5], or myoepithelial cells [12]. Based on previous studies [12,21,22], Rosen [8] suggested that the majority of these lesions represent adenosis tumours with leiomyomatous metaplasia of the myoepithelial components.…”

Section: Case Reportmentioning

confidence: 99%

“…In general, it is thought that the smooth muscle component in MH could originate from the smooth muscle cells of vessels, the nipple [11], undifferentiated breast tissue stroma [5], or myoepithelial cells [12]. Based on previous studies [12,21,22], Rosen [8] suggested that the majority of these lesions represent adenosis tumours with leiomyomatous metaplasia of the myoepithelial components. If the theory of transformation of myoepithelial cells into smooth muscle cells is correct, then at least some of the cells should express the protein S-100 or CD10 as markers of myoepithelial differentiation.…”

Section: Case Reportmentioning

confidence: 99%

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Kajo¹,

Žúbor

Danko³

2010

Breast Care

View full text Add to dashboard Cite

Background: Myoid (muscular) hamartoma (MH) of the breast is a rare benign tumour-forming lesion composed of differentiated mammary glandular and stromal structures, fatty tissue, and areas of smooth muscle. It is considered to be a variant of mammary hamartoma. Case Report: We report the case of a 46-year-old woman with MH, and provide a literature review explaining the origin of smooth muscle cells. Histologically, the tumour consisted of fibrolipomatous stroma containing ductal and lobular structures of the mammary gland located mainly at the tumour borders. The glandular structures showed signs of micro- and macrocystic changes, apocrine metaplasia, and adenosis. The dominant feature was the presence of a fascicular formation of spindle cells, predominantly in central parts, with incursion between glandular structures. Immunohistochemically, foci of smooth muscle tissue were positive for desmin, smooth muscle actin, and h-caldesmon. Oestrogen and progesterone receptors (PR) showed positive expression which was markedly higher for PR. There was negative expression of CD34, S-100 protein, and CD10. Conclusions: The origin of smooth muscle cells in MH is unknown. However, it is presumed to be derived from hormonally responsive breast stromal cells by smooth muscle metaplasia, based on evidence of hormone receptor expression in the lesion.

show abstract

“…Hamartoma is an uncommon breast tumor that histologically contains lobular breast tissue with various admixtures of fibrous, fibrocystic, and adipose tissue [1,2]. Myoid hamartoma is an extremely rare subtype containing an additional smooth muscle component [3].…”

Section: Introductionmentioning

confidence: 99%

Myoid hamartoma of the breast that proved difficult to diagnose: a case report

et al. 2012

View full text Add to dashboard Cite

Myoid hamartomas of the breast are extremely rare breast lesions, with a poorly understood pathogenesis. We describe the case of a 38-year-old premenopausal woman who presenting with a mass in the left breast. Mammography revealed an oval mass that was partly indistinct, and ultrasonography showed a hypoechoic mass with a slightly irregular margin. Bilateral breast dynamic magnetic resonance imaging was performed for a more detailed evaluation. The images showed rapid initial enhancement and a microlobulated margin. Because the suspicion of malignancy was strong at that time, core needle biopsy was performed. Histologically, the tumor was identified as fibroadenoma. A case of myoid hamartoma of the breast that proved difficult to diagnose is reported, and discussed with reference to the literature.

show abstract

Myoid hamartomas of the breast

Cited by 44 publications

References 8 publications

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis

Myoid (Muscular) Hamartoma of the Breast: Case Report and Review of the Literature

Myoid hamartoma of the breast that proved difficult to diagnose: a case report

Contact Info

Product

Resources

About