Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue

Li, Fengna; Li, Yinghui; Duan, Yehui; Hu, Chien‐An Andy; Tang, Yulong; Yin, Yulong

doi:10.1016/j.cytogfr.2016.10.003

Cited by 229 publications

(167 citation statements)

References 108 publications

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“…Adipose tissue is not only an energy store but also an endocrine organ that synthesizes and releases adipokines, such as adiponectin and leptin, both of which play vital roles in food intake, energy expenditure, and glucose homeostasis regulation . Obesity is characterized by excessive accumulation of fat, resulting from an imbalance between energy intake and energy expenditure and is thought to be a condition of chronic inflammation and oxidative stress.…”

Section: Energy Metabolism For Taurine Single Usementioning

confidence: 99%

“…Metabolic alterations in a peripheral organ can affect the physiology of other peripheral tissues . Organs communicate through hormonal signaling, feeding behavior, and control of energy homeostasis . The skeletal muscle system and adipose tissue are recognized as endocrine organs.…”

Section: Communication Between Organsmentioning

confidence: 99%

“…The skeletal muscle system and adipose tissue are recognized as endocrine organs. they secret myokines and adipokines, such as adiponectin and leptin, to target other metabolic organs (liver, skeletal muscle, and adipose tissue), thus modulating systemic energy homeostasis . Mitochondria integrate multiple physiological signals and their abnormalities favor biological processes in other tissues.…”

Section: Communication Between Organsmentioning

confidence: 99%

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Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Cui

Zhang

et al. 2018

Molecular Nutrition Food Res

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146

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Energy metabolism is a basic and general process, by which the body acquires and uses energy to maintain normal function, and taurine plays a vital role in energy metabolism. Taurine deficiency may cause a weak energy metabolism and energy metabolism dysfunction. Taurine biosynthetic ability is limited, and its supplementation in the diet can strengthen energy metabolism in muscle performance, cardiac function, liver activity, and adipose tissue. Combining taurine with other drugs may have a superior effect in energy metabolism. In many metabolic disorders, taurine, or the combination of taurine with other drugs, also functions as a repair treatment for damaged tissues, and acts as a promoter for the balance of energy metabolism. The present study discusses the potential roles of taurine in energy metabolism.

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Section: Energy Metabolism For Taurine Single Usementioning

confidence: 99%

Section: Communication Between Organsmentioning

confidence: 99%

Section: Communication Between Organsmentioning

confidence: 99%

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Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Cui

Zhang

et al. 2018

Molecular Nutrition Food Res

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146

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“…Ojima, Oe, Nakajima, Muroya, and Nishimura (2016) have demonstrated that extracellular matrix components were predominantly released during the early and middle stages of adipocyte differentiation, with a subsequent increase in the secretion of adipokines, suggesting that 3T3-L1 cells secrete adipokines after their ECM is constructed during adipocyte differentiation. Interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFα) are cytokines secreted in both tissues (called "adipo-myokines"), and they play key roles in the rate and extent of adipogenesis, myogenesis, lipogenesis, and lipolysis (Argiles, López-Soriano, Almendro, Busquets, & López-Soriano, 2005;Hoene, Runge, Häring, Schleicher, & Weigert, 2012;Li et al, 2017). Hence, they are thought to be involved in maintaining suitable skeletal muscle and adipose tissue mass ratios in normal conditions.…”

mentioning

confidence: 99%

Adipocytes suppress differentiation of muscle cells in a co‐culture system

Seo

Suzuki

Kobayashi

et al. 2018

Animal Science Journal

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The development of adipose tissue in skeletal muscle is important for improving meat quality. However, it is still unclear how adipocytes grow in the proximity of muscle fibers. We hypothesized that adipocytes would suppress muscle cell growth so as to grow dominantly within muscle. In this study, we investigated the effect of adipocytes on the differentiation of muscle cells in a co‐culture system. The fusion index of C2C12 myoblasts co‐cultured with 3T3‐L1 adipocytes was significantly lower than that of the control. The expression of myogenin and myosin heavy chain in C2C12 muscle cells co‐cultured with 3T3‐L1 adipocytes was significantly lower than in the control. Furthermore, the expression of Atrogin‐1 and MuRF‐1 was higher in C2C12 muscle cells co‐cultured with 3T3‐L1 adipocytes than the control. These results suggest that 3T3‐L1 adipocytes suppress the differentiation of C2C12 myoblasts. In addition, 3T3‐L1 adipocytes induced the expression and secretion of IL‐6 in C2C12 muscle cells. The fusion index and myotube diameter were higher in C2C12 muscle cells co‐cultured with 3T3‐L1 cells in medium containing IL‐6‐neutralizing antibody than the control. Taken together, there is a possibility that adipocyte‐induced IL‐6 expression in muscle cells could be involved in the inhibition of muscle cell differentiation via autocrine.

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“…Beyond considerable insight into the role of IMTG in acute and chronic exercise training (8) and according to the proposed crosstalk between myokines/cytokines and adipokines in skeletal muscle and adipose tissue (9), there are still questions to be answered about the link of interferons (IFNs), alpha as well as gamma, and IMTG in obesity. Indeed,, some data show that IFN-gamma, which is released from inflamed omental adipose tissue, may contribute to the metabolic abnormalities seen in human obesity (10).…”

Section: Introductionmentioning

confidence: 99%

Interferon-alpha2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

Tarantino

Costantini²,

Citro³

et al. 2018

Preprint

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Myokines and adipokines: Involvement in the crosstalk between skeletal muscle and adipose tissue

Cited by 229 publications

References 108 publications

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Taurine is Involved in Energy Metabolism in Muscles, Adipose Tissue, and the Liver

Adipocytes suppress differentiation of muscle cells in a co‐culture system

Interferon-alpha2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

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