Myometrial responses in situ to nicergoline, acebutolol, phentolamine and noradrenaline of the rat in proestrus

Acritopoulou-Fourcroy, Stella; Clabaut, M; Schrub, J. C.

doi:10.1016/0014-2999(84)90091-8

Cited by 3 publications

(1 citation statement)

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“…While there are numerous publications describing the effects of adrenoceptor agonists and antagonists on smooth muscle, few if any reports are available concerning their action on the pro-oestral rat uterus. In a recent study, we compared the myometrial responses of two adrenoceptor antagonists with those of noradrenaline and phentolamine in the rat during pro-oestrus (Acritopoulou-Fourcroy et al, 1984). In the current investigation, on the pro-oestrous rat, we aimed to allow the expression in vivo of the amyometrial adrenoceptors in order to determine their involvement in myometrial activity.…”

Section: Introductionmentioning

confidence: 99%

Involvement of α‐adrenoceptors in myometrial responses in the pro‐oestral rat

Acritopoulou-Fourcroy

Marcais-Collado

1988

British J Pharmacology

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Myometrial responses to different agents acting on adrenoceptors were examined in vivo in the pro‐oestrous rat. Changes in spontaneous uterine mechanical activity were recorded isometrically and evaluated in terms of amplitude and duration of uterine contractions. Phenylephrine (10 μg kg−1) markedly increased the amplitude and duration of contractions and 40 μg kg−1 gave rise to tetanic contractions. Administration of either nicergoline (400 μg kg−1) or phentolamine (1000 μg kg−1) to phenylephrine‐primed rat uterus reduced the strength of contractions and phentolamine abolished the phenylephrine‐induced uterine contracture. Following blockade of α2‐adrenoceptors by yohimbine (1000 μg kg−1) and β‐adrenoceptors by propranolol (2400 μg kg−1), a single injection of phenylephrine (100 μg kg−1) increased the amplitude of uterine contractions by 30%. Noradrenaline reduced the amplitude of contractions and caused elevation of the baseline level. The response of myometrium to the combination of both propranolol and noradrenaline was the establishment of uterine contracture with subsequent increase of the duration of contractions. These results clearly demonstrate the involvement of α‐adrenoceptors in the myometrial activity of the rat in vivo during pro‐oestrus.

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Section: Introductionmentioning

confidence: 99%