2016
DOI: 10.1098/rspb.2015.3030
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Myosin filament sliding through the Z-disc relates striated muscle fibre structure to function

Abstract: Striated muscle contraction requires intricate interactions of microstructures. The classic textbook assumption that myosin filaments are compressed at the meshed Z-disc during striated muscle fibre contraction conflicts with experimental evidence. For example, myosin filaments are too stiff to be compressed sufficiently by the muscular force, and, unlike compressed springs, the muscle fibres do not restore their resting length after contractions to short lengths. Further, the dependence of a fibre's maximum c… Show more

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Cited by 23 publications
(38 citation statements)
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“…Some properties of cou- 13 pled contraction-activation dynamics are well-established, 14 for instance the force-length relation of muscle fibers 15 [4,5, 11,21,35,36,45,79,84,98] or the visco-elastic characteristics of 16 tendon material [34,49,50,73,75,76,80,107] . A near-static condition, 17 such as an isometric contraction, is appropriate for determining 18 static properties, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…Some properties of cou- 13 pled contraction-activation dynamics are well-established, 14 for instance the force-length relation of muscle fibers 15 [4,5, 11,21,35,36,45,79,84,98] or the visco-elastic characteristics of 16 tendon material [34,49,50,73,75,76,80,107] . A near-static condition, 17 such as an isometric contraction, is appropriate for determining 18 static properties, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…Data and individual regression lines are shown for all seven muscles. myofilament grid (that is possibly hexagonal and tetragonal (Rode et al, 2016)) might be reduced in the direction of the transversal load, and, due to volume constancy, increased in the transversal perpendicular direction. The cross-bridges formed between transversally more distant filaments would have stronger transversal pulling components opposing the transversal deformation induced by the load, pulling the filaments together and tending to restore the crystalline structure.…”
Section: Discussionmentioning
confidence: 97%
“…Additional assumptions were required to extend the resulting linear behaviour to other regions of the FLR. However, there are several strong arguments against myosin compression [8]. To approach the physiological mechanisms, it is important to separate cross-bridge and non-cross-bridge contributions to total muscle force.…”
Section: Discussionmentioning
confidence: 99%
“…to stabilize posture, decelerate, or prepare reutilization of stored energy for power enhancement [5,7]. However, processes underlying lengthening contractions on the molecular level remain unclear (see Nomenclature table in the electronic supplementary material). A novel, physiological model of fibre contraction [8] extends the wellaccepted mechanisms of active force production in sarcomeres-the sliding filament [9,10] and cross-bridge theories [11]-to short sarcomere lengths (figure 1a, range left of D). However, these theories fail spectacularly when predicting the isometric muscle force after an active eccentric contraction, for example [13].…”
Section: Introductionmentioning
confidence: 99%
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