Myosin Light Chain Kinase Is Involved in the Mechanism of Gastrointestinal Dysfunction in Diabetic Rats

Hu, Wenchao; Feng, Ping

doi:10.1007/s10620-012-2041-7

Cited by 18 publications

(18 citation statements)

References 22 publications

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“…In the present study, we found that diabetic rats induced by STZ had a less gastric contraction and poor gastric emptying after 6 weeks. Hu and Feng had the same results in their experimental study . After LESW, we found increasing gastric contraction and enhancing gastric emptying in diabetic rats.…”

Section: Discussionsupporting

confidence: 64%

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Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

Chiu

Yao

et al. 2018

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 64%

“…Hu and Feng had the same results in their experimental study. 21 After LESW, we found increasing gastric contraction and enhancing gastric emptying in diabetic rats. This shows that LESW could increase gastric contractions and motility in diabetic rats.…”

Section: Discussionmentioning

confidence: 76%

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

Chiu

Yao

et al. 2018

J of Gastro and Hepatol

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“…Insulin treatment significantly improved gastric emptying by restoring MLCK levels. 35) In addition, we also found that ICC-IM in aging normal control rats were significantly reduced at 28th week compared to 12th week. The age-related ICC loss presented in this study is consistent with a recent study in aging humans that showed a marked loss of ICCs in normal human stomach and colon with age.…”

Section: )supporting

confidence: 57%

<sup>13</sup>C-Acetic Acid Breath Test Monitoring of Gastric Emptying during Disease Progression in Diabetic Rats

Muangchan

Kooptiwut

Tapechum

et al. 2017

Biological & Pharmaceutical Bulletin

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Gastric motility disturbance is commonly found in long-standing hyperglycemia. Both delayed and rapid gastric emptying has been reported in diabetes. However, very few studies have followed the changes in gastric emptying during disease progression in diabetes because of technical limitations.13 C-Acetic acid breath test is a validated method which is non-invasive and can be used repeatedly or serially to evaluate gastric emptying changes in animal. We investigated the gastric emptying changes in different stages of diabetes using 13 C-acetic acid breath test, as well as its related mechanisms involving interstitial cells of Cajal (ICCs), and stem cell factor (SCF) in streptozotocin-induced diabetic rats. The results showed that gastric emptying was accelerated at the early stage (12 weeks of diabetes) whereas intramuscular ICCs (ICC-IM) networks were not different from normal group. At long-term stage (28 weeks of diabetes), gastric emptying had returned to normal pattern with no delayed. ICC-IM networks were decreased in the diabetic group compared to 12th weeks, and were lower than in the normal group at the same time point. SCF levels were constantly high in the diabetic group than in the normal group. This result indicated that 13 C-acetic acid breath test is useful to track the alteration in gastric emptying during disease progression. The change of gastric emptying was not found to be significantly associated with ICC-IM. Elevated SCF may help to preserve ICC-IM, especially in the early phase of diabetes.

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“…In a study of STZ‐DM rats, the expression of MLCK was significantly reduced in the smooth muscles of pylorus and ileum. This effect was reversible with insulin treatment …”

Section: Introductionmentioning

confidence: 96%

Diabetic gastrointestinal motility disorders and the role of enteric nervous system: Current status and future directions

Yarandi

Srinivasan

2014

Neurogastroenterology Motil

169

151

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Gastrointestinal manifestations of diabetes are common and a source of significant discomfort and disability. Diabetes affects almost every part of gastrointestinal tract from the esophagus to the rectum and causes a variety of symptoms including heartburn, nausea, vomiting, abdominal pain, diarrhea and constipation. Understanding the underlying mechanisms of diabetic gastroenteropathy is important to guide development of therapies for this common problem. Over recent years, the data regarding the pathophysiology of diabetic gastroenteropathy is expanding. In addition to autonomic neuropathy causing gastrointestinal disturbances the role of enteric nervous system is becoming more evident. In this review, we summarize the reported alterations in enteric nervous system including enteric neurons, interstitial cells of Cajal and neurotransmission in diabetic animal models and patients. We also review the possible underlying mechanisms of these alterations, with focus on oxidative stress, growth factors and diabetes induced changes in gastrointestinal smooth muscle. Finally, we will discuss recent advances and potential areas for future research related to diabetes and the ENS such as gut microbiota, micro-RNAs and changes in the microvasculature and endothelial dysfunction.

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Myosin Light Chain Kinase Is Involved in the Mechanism of Gastrointestinal Dysfunction in Diabetic Rats

Abstract: Decreased expression of MLCK in gastrointestinal tissues could be a possible cause for gastrointestinal dysfunction. Insulin may partly ameliorate gastrointestinal dysfunction by restoring the expression of MLCK.

Cited by 18 publications

References 22 publications

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

<sup>13</sup>C-Acetic Acid Breath Test Monitoring of Gastric Emptying during Disease Progression in Diabetic Rats

Diabetic gastrointestinal motility disorders and the role of enteric nervous system: Current status and future directions

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