Myosin’s powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin
Michael J. Rynkiewicz,
Matthew C. Childers,
Olga E. Karpicheva
et al.
Abstract:Dynamic interactions between the myosin motor head on thick filaments and the actin molecular track on thin filaments drive the myosin-crossbridge cycle that powers muscle contraction. The process is initiated by Ca2+ and the opening of troponin–tropomyosin–blocked myosin-binding sites on actin. The ensuing recruitment of myosin heads and their transformation from pre-powerstroke to post-powerstroke conformation on actin produce the force required for contraction. Cryo-EM-based atomic models confirm that durin… Show more
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